Links between parental life histories of wild salmon and the telomere lengths of their offspring

The importance of parental contributions to offspring development and subsequent performance is self-evident at a genomic level; however, parents can also affect offspring fitness by indirect genetic and environmental routes. The life history strategy that an individual adopts will be influenced by both genes and environment; and this may have important consequences for offspring. Recent research has linked telomere dynamics (i.e. telomere length and loss) in early life to future viability and longevity. Moreover, a number of studies have reported a heritable component to telomere length across a range of vertebrates, though the effects of other parental contribution pathways have been far less studied. By using wild Atlantic salmon with different parental life histories in an experimental split-brood IVF mating design and rearing the resulting families under standardised conditions, we show that there can be significant links between parental life history and offspring telomere length (studied at the embryo and fry stage). Maternal life history traits, in particular egg size, were most strongly related to offspring telomere length at the embryonic stage, but then became weaker through development. In contrast, paternal life history traits, such as the father's growth rate in early life, had a greater association in the later stages of offspring development. However, offspring telomere length was not significantly related to either maternal or paternal age at reproduction, nor to paternal sperm telomere length. This study demonstrates both the complexity and the importance of parental factors that can influence telomere length in early life

An assessment of the mantle and slab components in the magmas of an oceanic arc volcano: Raoul Volcano, Kermadec arc

Raoul Volcano occupies a simple oceanic subduction setting in the northern part of the Kermadec arc on the Pacific–Australian convergent plate boundary. The primary inputs to the magmatic system that feeds the volcano are a subduction component derived from the subducting old Pacific oceanic lithosphere and its veneer of pelagic sediment, and the overlying peridotitic mantle wedge. Conservative trace elements that are very incompatible during mantle melting are relatively depleted in Raoul lavas indicating a source that has been depleted during an earlier melting event. Major element co-variations indicate magma genesis by 25% near fractional melting of a mantle source that is weakly depleted (2% melt extraction) relative to a fertile MORB source. An important influence on the composition of the mantle component is progressive melt extraction coupled with minimal advection of fresh material into the sub-arc zone followed by melt extraction from a melting column beneath the spreading centre of an adjacent back arc basin. High field strength element and rare earth element systematics indicate involvement of a subduction-related component of constant composition. Two fluid components can be distinguished, one enriched in large ion lithophile elements inferred to be an aqueous fluid that is continuously added to the ascending melt column and the other a less mobile fluid that transfers Th. A homogeneous subduction-related component of constant composition and magnitude arises if the slab-derived flux migrates from the slab–mantle interface to the sub-arc melting column by repeated episodes of amphibole formation and decomposition its composition is then governed by the distribution coefficients of pyroxene and its magnitude by the degree of amphibole saturation of mantle peridotite. The results from Raoul Volcano are comparable to those from other oceanic subduction-related arcs such as South Sandwich and Marianas suggesting that this is a general model for oceanic arcs

TIGER Capacity Building Facility - Phase 1, lessons learnt

The TIGER Capacity Building Facility focused on closing the technological gap between the users and the earth observation community within the TIGER programme. Thirteen projects participated in different aspects of the capacity building facility: 1. - Basic education, provided via distance learning. 2. - Tailored short courses, selected according to the research interest and technical background of the participants. 3. - Research topic oriented supervision, provided by specialists of the research fields of the participants. 4. - Advanced short courses focusing on selected earth observation techniques. Distance education turned to be efficient and cost effective in the programme - but only for those, who followed the courses completely. There was a relatively large percentage that could not complete the studies. The second and the third type of education were carried out in ITC, in the Netherlands. The participants evaluated the courses and the supervision very effective and adequate. Nevertheless, the follow-up was not always possible. Two advanced short courses were held in Africa (Cape Town and Nairobi). One of them addressed the 'scientific elite' of the EO community, whilst the second focused on the users of this technology

Adjustable high emittance gap filler

A flexible, adjustable refractory filler is disclosed for filling gaps between ceramic tiles forming the heat shield of a space shuttle vehicle, to protect its aluminum skin during atmospheric reentry. The easily installed and replaced filler consists essentially of a strip of ceramic cloth coated, at least along both its longitudinal edges with a room temperature vulcanizable silicone rubber compound with a high emittance colored pigment. The filler may have one or more layers as the gap width requires. Preferred materials are basket weave aluminoborosilicate cloth, and a rubber compounded with silicon tetraboride as the emittance agent and finely divided borosilicate glass containing about 7.5% B2O3 as high temperature binder. The filler cloth strip or tape is cut to proper width and length, inserted into the gap, and fastened with previously applied drops of silicone rubber adhesive

Imaging the Near Field

In an earlier paper we introduced the concept of the perfect lens which focuses both near and far electromagnetic fields, hence attaining perfect resolution. Here we consider refinements of the original prescription designed to overcome the limitations of imperfect materials. In particular we show that a multi-layer stack of positive and negative refractive media is less sensitive to imperfections. It has the novel property of behaving like a fibre-optic bundle but one that acts on the near field, not just the radiative component. The effects of retardation are included and minimized by making the slabs thinner. Absorption then dominates image resolution in the near-field. The deleterious effects of absorption in the metal are reduced for thinner layers.Comment: RevTeX, (9 pages, 8 figures

Data management of nanometre­ scale CMOS device simulations

In this paper we discuss the problems arising in managing and curating the data generated by simulations of nanometre scale CMOS (Complementary Metal–Oxide Semiconductor) transistors, circuits and systems and describe the software and operational techniques we have adopted to address them. Such simulations pose a number of challenges including, inter alia, multi­TByte data volumes, complex datasets with complex inter-relations between datasets, multi­-institutional collaborations including multiple specialisms and a mixture of academic and industrial partners, and demanding security requirements driven by commercial imperatives. This work was undertaken as part of the NanoCMOS project. However, the problems, solutions and experience seem likely to be of wider relevance, both within the CMOS design community and more generally in other disciplines

Behaviour of a shear-wave at a solid-smectic interface

Results of theoretical investigations into the behaviour of a shear wave at the boundary between an isotropic solid and a smectic A liquid crystal are presented. These results track the subsequent response of the smectic to the refracted wave. Using the techniques of Landau and Lifshitz for sound in isotropic fluids [1], we extend the results for smectic C by Gill and Leslie [2] and perform the analogous calculations for a sample of smectic A using the dynamic theory of Stewart [3]. These calculations enable a comparison between the results for smectic A and an extension, by the present authors, to the known results for smectic C. Motivated by the work of Auernhammer, Brand, and Pleiner [4, 5], mechanisms for determining the impact of perturbations upon the modes of response behaviour will be analysed, with plots demonstrating the amplitudes of these waves relative to that of the incident wave displayed for a range of typical physical parameters characteristic to smectic C and smectic A

Significant differences in incubation times in sheep infected with bovine spongiform encephalopathy result from variation at codon 141 in the PRNP gene

The susceptibility of sheep to prion infection is linked to variation in the PRNP gene, which encodes the prion protein. Common polymorphisms occur at codons 136, 154 and 171. Sheep which are homozygous for the A<sub>136</sub>R<sub>154</sub>Q<sub>171</sub> allele are the most susceptible to bovine spongiform encephalopathy (BSE). The effect of other polymorphisms on BSE susceptibility is unknown. We orally infected ARQ/ARQ Cheviot sheep with equal amounts of BSE brain homogenate and a range of incubation periods was observed. When we segregated sheep according to the amino acid (L or F) encoded at codon 141 of the PRNP gene, the shortest incubation period was observed in LL141 sheep, whilst incubation periods in FF<sub>141</sub> and LF<sub>141</sub> sheep were significantly longer. No statistically significant differences existed in the expression of total prion protein or the disease-associated isoform in BSE-infected sheep within each genotype subgroup. This suggested that the amino acid encoded at codon 141 probably affects incubation times through direct effects on protein misfolding rates