The Amplitude of Non-Equilibrium Quantum Interference in Metallic Mesoscopic Systems

We study the influence of a DC bias voltage V on quantum interference corrections to the measured differential conductance in metallic mesoscopic wires and rings. The amplitude of both universal conductance fluctuations (UCF) and Aharonov-Bohm effect (ABE) is enhanced several times for voltages larger than the Thouless energy. The enhancement persists even in the presence of inelastic electron-electron scattering up to V ~ 1 mV. For larger voltages electron-phonon collisions lead to the amplitude decaying as a power law for the UCF and exponentially for the ABE. We obtain good agreement of the experimental data with a model which takes into account the decrease of the electron phase-coherence length due to electron-electron and electron-phonon scattering.Comment: New title, refined analysis. 7 pages, 3 figures, to be published in Europhysics Letter

Current-induced two-level fluctuations in pseudo spin-valves (Co/Cu/Co) nanostructures

Two-level fluctuations of the magnetization state of pseudo spin-valve pillars Co(10 nm)/Cu(10 nm)/Co(30 nm) embedded in electrodeposited nanowires (~40 nm in diameter, 6000 nm in length) are triggered by spin-polarized currents of 10^7 A/cm^2 at room temperature. The statistical properties of the residence times in the parallel and antiparallel magnetization states reveal two effects with qualitatively different dependences on current intensity. The current appears to have the effect of a field determined as the bias field required to equalize these times. The bias field changes sign when the current polarity is reversed. At this field, the effect of a current density of 10^7 A/cm^2 is to lower the mean time for switching down to the microsecond range. This effect is independent of the sign of the current and is interpreted in terms of an effective temperature for the magnetization.Comment: 4 pages, 5 figures, revised version, to be published in Phys. Rev. Let

Periodic Modulations in an X-ray Flare from Sagittarius A*

We present the highly significant detection of a quasi-periodic flux modulation with a period of 22.2 min seen in the X-ray data of the Sgr A* flare of 2004 August 31. This flaring event, which lasted a total of about three hours, was detected simultaneously by EPIC on XMM-Newton and the NICMOS near-infrared camera on the HST. Given the inherent difficulty in, and the lack of readily available methods for quantifying the probability of a periodic signal detected over only several cycles in a data set where red noise can be important, we developed a general method for quantifying the likelihood that such a modulation is indeed intrinsic to the source and does not arise from background fluctuations. We here describe this Monte Carlo based method, and discuss the results obtained by its application to a other XMM-Newton data sets. Under the simplest hypothesis that we witnessed a transient event that evolved, peaked and decayed near the marginally stable orbit of the supermassive black hole, this result implies that for a mass of 3.5 x 10^{6} Msun, the central object must have an angular momentum corresponding to a spin parameter of a=0.22.Comment: 4 pages, 6 figures, submitted to ApJ

The signature of 44Ti in Cassiopeia A revealed by IBIS/ISGRI on INTEGRAL

We report the detection of both the 67.9 and 78.4 keV 44Sc gamma-ray lines in Cassiopeia A with the INTEGRAL IBIS/ISGRI instrument. Besides the robustness provided by spectro-imaging observations, the main improvements compared to previous measurements are a clear separation of the two 44Sc lines together with an improved significance of the detection of the hard X-ray continuum up to 100 keV. These allow us to refine the determination of the 44Ti yield and to constrain the nature of the nonthermal continuum emission. By combining COMPTEL, BeppoSAX/PDS and ISGRI measurements, we find a line flux of (2.5 +/- 0.3)*10(-5) cm(-2) s(-1) leading to a synthesized 44Ti mass of 1.6 (+0.6-0.3)*10(-4) solar mass. This high value suggests that Cas A is peculiar in comparison to other young supernova remnants, from which so far no line emission from 44Ti decay has been unambiguously detected.Comment: 5 pages, 4 figures, Accepted for publication in ApJ

Discovery of new TeV supernova remnant shells in the Galactic plane with H.E.S.S

Supernova remnants (SNRs) are prime candidates for efficient particle acceleration up to the knee in the cosmic ray particle spectrum. In this work we present a new method for a systematic search for new TeV-emitting SNR shells in 2864 hours of H.E.S.S. phase I data used for the H.E.S.S. Galactic Plane Survey. This new method, which correctly identifies the known shell morphologies of the TeV SNRs covered by the survey, HESS J1731-347, RX 1713.7-3946, RCW 86, and Vela Junior, reveals also the existence of three new SNR candidates. All three candidates were extensively studied regarding their morphological, spectral, and multi-wavelength (MWL) properties. HESS J1534-571 was associated with the radio SNR candidate G323.7-1.0, and thus is classified as an SNR. HESS J1912+101 and HESS J1614-518, on the other hand, do not have radio or X-ray counterparts that would permit to identify them firmly as SNRs, and therefore they remain SNR candidates, discovered first at TeV energies as such. Further MWL follow up observations are needed to confirm that these newly discovered SNR candidates are indeed SNRs

Transcription of a β-1,3-glucanase gene in grape berries in a late developmental period, or earlier after wounding treatments

The hydrolytic enzymes β-1,3-glucanases (EC3.2.1.39) an known to be involved in plant defense reactions against pathogens and in developmental events. We have obtained two partial cDNA clones, corresponding to Vitis vinifera β-1,3-glucanase gene sequences (VvGlu1/7 and VvGlu26). The expression of VvGlu1/7 was studied in grape berries at different developmental stages and in wounded berries with or without salicylic acid elicitation. No constitutive expression was observed in young berries, whereas the induction of VvGlu1/7 transcription was detected during fruit ripening. By contrast, synthesis of mRNA coding for this isoform was generated in the first stage of rapid berry growth in response to wounding treatments with and without salicylic acid

Subclinical giant cell arteritis in polymyalgia rheumatica: Concurrent conditions or a common spectrum of inflammatory diseases?

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common conditions in older adults. Their clinical connection has been recognized over time, with many patients experiencing both conditions separately, simultaneously or in temporal sequence to each other. Early GCA detection is essential to prevent vascular damage, but identifying subclinical GCA in PMR patients remains a challenge and routine screening is not standard practice. Subclinical GCA prevalence in newly diagnosed PMR patients ranges from 23 to 29%, depending on the screening method. Vessel wall imaging and temporal artery biopsy can detect subclinical GCA. Epidemiology and trigger factors show similarities between the two conditions, but PMR is more common than GCA. Genetic and pathogenesis studies reveal shared inflammatory mechanisms involving dendritic cells, pro-inflammatory macrophages, and an IL-6 signature. However, the inflammatory infiltrates differ, with extensive T cell infiltrates seen in GCA while PMR shows an incomplete profile of T cell and macrophage-derived cytokines. Glucocorticoid treatment is effective for both conditions, but the steroid requirements vary. PMR overall mortality might be similar to the general population, while GCA patients with aortic inflammatory aneurysms face increased mortality risk. The GCA-PMR association warrants further research. Considering their kinship, recently the term GCA-PMR Spectrum Disease (GPSD) has been proposed

INTEGRAL detection of hard X-rays from NGC 6334: Nonthermal emission from colliding winds or an AGN?

We report the detection of hard X-ray emission from the field of the star-forming region NGC 6334 with the the International Gamma-Ray Astrophysics Laboratory INTEGRAL. The JEM-X monitor and ISGRI imager aboard INTEGRAL and Chandra ACIS imager were used to construct 3-80 keV images and spectra of NGC 6334. The 3-10 keV and 10-35 keV images made with JEM-X show a complex structure of extended emission from NGC 6334. The ISGRI source detected in the energy ranges 20-40 keV and 40-80 keV coincides with the NGC 6334 ridge. The 20-60 keV flux from the source is (1.8+-0.37)*10(-11) erg cm(-2) s(-1). Spectral analysis of the source revealed a hard power-law component with a photon index about 1. The observed X-ray fluxes are in agreement with extrapolations of X-ray imaging observations of NGC 6334 by Chandra ACIS and ASCA GIS. The X-ray data are consistent with two very different physical models. A probable scenario is emission from a heavily absorbed, compact and hard Chandra source that is associated with the AGN candidate radio source NGC 6334B. Another possible model is the extended Chandra source of nonthermal emission from NGC 6334 that can also account for the hard X-ray emission observed by INTEGRAL. The origin of the emission in this scenario is due to electron acceleration in energetic outflows from massive early type stars. The possibility of emission from a young supernova remnant, as suggested by earlier infrared observations of NGC 6334, is constrained by the non-detection of 44Ti lines.Comment: 8 pages, 8 figures, Astronomy and Astrophysics (in press

Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection

International audienceThe interplay between influenza A viruses (IAV) and the p53 pathway has been reported in several studies, highlighting the antiviral contribution of p53. Here, we investigated the impact of IAV on the E3-ubiquitin ligase Mdm2, a major regulator of p53, and observed that IAV targets Mdm2, notably via its non-structural protein (NS1), therefore altering Mdm2 stability, p53/Mdm2 interaction and regulatory loop during the time-course of infection. This study also highlights a new antiviral facet of Mdm2 possibly increasing the list of its many p53-independent functions. Altogether, our work contributes to better understand the mechanisms underlining the complex interactions between IAV and the p53 pathway, for which both NS1 and Mdm2 arise as key players