Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy in high myopia: a prospective clinical study

BACKGROUND: To study the effect of prophylactic application of mitomycin-C on haze formation in photorefractive keratectomy (PRK) for high myopia. METHODS: Fifty-four eyes of 28 myopic patients were enrolled in this prospective study. All eyes were operated by PRK followed by 0.02% mitomycin-C application for two minutes and washed with 20 ml normal saline afterwards. All eyes were examined thoroughly on the first 7 days and one month after surgery; 48 eyes (88.9%) at 3 and 6 months postoperatively. Hanna grading (in the scale of 0 to 4+) was used for assessment of corneal haze. RESULTS: The mean spherical equivalent refraction (SE) was -7.08 diopters (D) ± 1.11 (SD) preoperatively. Six months after surgery, 37 eyes (77.1%) achieved an uncorrected visual acuity (UCVA) of 20/20 or better, all eyes had a UCVA of 20/40 or better and 45 (93.7%) eyes had an SE within ± 1.00D. One month postoperatively, 2 eyes (3.7%) had grade 0.5+ of haze, while at 3 and 6 months after surgery no visited eye had haze at all. All eyes had a best corrected visual acuity (BCVA) of 20/40 or better and there were no lost lines in BCVA by 6 months after surgery. In spatial frequencies of 6 and 12 cycles per degree contrast sensitivity had decreased immediately after PRK and it had increased 1.5 lines by the 6(th )postoperative month compared to the preoperative data. CONCLUSIONS: The results show the efficacy of mitomycin-C in preventing corneal haze after treatment of high myopia with PRK. This method- PRK + mitomycin-C – can be considered an alternative treatment for myopic patients whose corneal thicknesses are inadequate for laser in situ keratomileusis (LASIK). However, the results should be confirmed in longer follow-ups

Development of Electrolarynx by Multi-agent Technology and Mobile Devices for Prosody Control

The feasibility of using a motion sensor to replace a conventional electrolarynx (EL) user interface was explored. A mobile phone motion sensor with multi-agent platform was used to investigate on/off and pitch frequency control capability. A very small battery operated ARM-based control unit was also developed to evaluate the motion sensor based user-interface. The control unit was placed on the wrist and the vibration device was placed against the throat using support bandage. Two different conversion methods were used for the forearm tilt angle to pitch frequency conversion: linear mapping method and F0 template-based method. A perceptual evaluation was performed with two well-trained normal speakers and ten subjects. The results of the evaluation study showed that both methods were able to produce better speech quality in terms of naturalness

An agent-based social simulation platform with 3D representation for labor integration of disabled people

In this paper, we present the design and implementation of a novel agent-based platform with 3D representations for labor integration. In order to evaluate and validate the proposed platform, a case study in a real workplace environment is modeled, with the purpose of identifying architectural barriers that hinder the accessibility and the processes of the workplace environment, allowing us to improve the accessibility of the environment to disabled people. Thereby, through the incorporation of novel simulation technics and mechanisms, it is possible to find areas that may be improved

Multiagent Application in Mobile Environments to Data Collection in Park Zones

[EN]This paper presents an application of automatic parking which assists users. For this, recognition techniques are used, such as the algorithm to recognize a license plate from a photograph or the use of NFC protocol to identify an object in the environment. As well, multiagent system integration will be necessary in order to communicate the different devices and data providers involved in this system. We obtain a system that assists the users in his payments and vehicle identification in an efficient way

Cancer incidence and mortality attributable to alcohol consumption

Alcohol consumption is a major cause of disease and death. In a previous study, we reported that in 2002, 3.6% of all cases of cancer and a similar proportion of cancer deaths were attributable to the consumption of alcohol. We aimed to update these figures to 2012 using global estimates of cancer cases and cancer deaths, data on the prevalence of drinkers from the World Health Organization (WHO) global survey on alcohol and health, and relative risks for alcohol-related neoplasms from a recent meta-analysis. Over the 10-year period considered, the total number of alcohol-attributable cancer cases increased to approximately 770,000 worldwide (5.5% of the total number of cancer cases)-540,000 men (7.2%) and 230,000 women (3.5%). Corresponding figures for cancer deaths attributable to alcohol consumption increased to approximately 480,000 (5.8% of the total number of cancer deaths) in both sexes combined-360,000 (7.8%) men and 120,000 (3.3%) women. These proportions were particularly high in the WHO Western Pacific region, the WHO European region and the WHO South-East Asia region. A high burden of cancer mortality and morbidity is attributable to alcohol, and public health measures should be adopted in order to limit excessive alcohol consumption