Speech Enhancement using DWT for Hearing Aid Application

Hearing impairment is the number one chronic disability affecting people in the world. With a loss of hearing, person is restricted from his or her normal social activity, which may in turn cause undesirable influence on mental health. An effective treatment for the problem is hearing assistive device called hearing aid. With reference to patient’s audiogram hearing aid device would enhance signal such that hearing impaired person can hear comfortably. It has been tried to implement same technical concept. Presented approach for speech enhancement for hearing aid by using discrete wavelet transform-multiresolution analysis. DOI: 10.17762/ijritcc2321-8169.150518

Pilot scale studies on the beneficiation of complex sulphides by flotation column

Experiments using pilot size flotation Column as cleaner cell were conducted to evolve a suitable flow sheet for the production of bulk sulphide concentrates of Cu-Pb-Zn. The flotalion circuit consisting of roughing, scavenging, and two stage cleaning by conventional flotation machines was compared with the circuit where two stage cleaning operation was replaced with single stage cleaning by flotation column. It is clearly demonstrated that a single stage cleaning by flotation column is more efficient and sufficient to obtain bulk concentrate suitable for further processing. Of the two types of sparger systems used viz, TURBO and MICROCEL, the former was found to be better to achieve high quality concentrate

Exploration of the Continental Margins of India

In mid 1970’s the Institute prepared a plan for systematic regional geological and geophysical surveys of the continental margins of India. This involved over 75,000 km of underway (bathymetric, side scan sonar, magnetic, gravity and seismic) surveys on tracks about 20 km apart, and collection of about 1500 seabed samples at about 10 to 20 km spacing. It was anticipated that the entire programme would require 22 ship’s months. This programme received considerable impetus from sponsored surveys of other organizations, chiefly the oil industry, ports and harbours as well as industries disposing of their effluents in the marine environment. By now the entire western continental shelf and a large part of the continental slope have been covered by about 68,314 km bathymetric surveys, 12,720 km side scan sonar surveys, 46,222 km magnetic surveys, 27,200 km seismic surveys (including 5,489 km multichannel seismic), and 9,065 km gravity surveys. Approximately 1500 seabed samples have been collected. These surveys, besides providing basic information on the morphology, sediments, and geochemistry of the sediments of the .western continental margin of India, have also led to the estimation of resources of offshore ilmenite placers and low grade phosphorite deposits. The data collected are proposed to be depicted in a series of maps showing the morphology, sediments and geochemistry of sediments

Investigation of some basic thermodynamic properties of Na-K alloy

Investigation of thermodynamic of liquid binary alloys using pseudopotential theory is reported. The potential suggested by Fiolhais et al. with its individual parameters is used for the entire calculation. A transferability of the potential from the solid to liquid medium is achieved for the presently reported binary alloy. The internal energy components, Helmholtz free energy, entropy, and total energy at various proportions of the participating alkali metals are included in the study. The comparison with the other data has been shown in the present article. Exchange and correlation effect is also tested with the help of various local field correction functions. BIBECHANA 18 (2) (2021) 1-

Thermodynamical Investigation of Liquid Alkali Metals with Gibbs-Bogoliubov Method

In this article, the framework has been prepared to investigate the various thermodynamical properties namely; entropy S, internal energy EINT and Helmholtz free energy FH of some liquid alkali metals using the universal model potential given by Fiolhais et al. with Percus-Yevick hard sphere (PYHS) reference system. The screening influence of six different local field correction functions proposed by Hartree (H), Taylor (T), Ichimaru-Utsumi (IU), Farid et al. (F), Sarkar et al. (S) and Nagy (N) for the first time with universal model potential are reported. A very good agreement between the presently computed data and experimentally available data is found

Investigation of some basic thermodynamic properties of Na-K alloy

Investigation of thermodynamic of liquid binary alloys using pseudopotential theory is reported. The potential suggested by Fiolhais et al. with its individual parameters is used for the entire calculation. A transferability of the potential from the solid to liquid medium is achieved for the presently reported binary alloy. The internal energy components, Helmholtz free energy, entropy, and total energy at various proportions of the participating alkali metals are included in the study. The comparison with the other data has been shown in the present article. Exchange and correlation effect is also tested with the help of various local field correction functions. BIBECHANA 18 (2) (2021) 1-

Thermodynamical Investigation of Liquid Alkali Metals with Gibbs–Bogoliubov Method

In this article, the framework has been prepared to investigate the various thermodynamical properties namely; entropy S, internal energy EINT and Helmholtz free energy FH of some liquid alkali metals using the universal model potential given by Fiolhais et al. with Percus-Yevick hard sphere (PYHS) reference system. The screening influence of six different local field correction functions proposed by Hartree (H), Taylor (T), Ichimaru-Utsumi (IU), Farid et al. (F), Sarkar et al. (S) and Nagy (N) for the first time with universal model potential of Fiolhais et al. are reported. A very good agreement between the presently computed data and experimentally available data is found

An immunohistochemical study of altered immunomodulatory molecule expression in head and neck squamous cell carcinoma.

For the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system, the expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary. There is increasing evidence that surface HLA class I antigen expression is altered in a variety of human tumours by either loss or down-regulation of these molecules, which may be a strategy for evasion of immunosurveillance by malignant cells. This study has examined the expression of HLA class I molecules in head and neck squamous cell carcinoma (HNSCC) specimens by immunohistochemistry, using a wide panel of antibodies directed against allele-specific as well as monomorphic determinants of these molecules. The expression of TAP proteins, HLA-DR and the co-stimulatory molecule ICAM-1 were also studied. In addition, the expression of the tumour-associated antigens (TAA) p53 and MAGE genes was determined. Aberrant allelic expression of HLA class I antigens was detected in 17 out of 34 (50%) of the specimens stained, whereas HLA class I expression determined by W6/32 staining was found to be heterogeneous in only 2 out of 34 (6%) cases. Decreased expression of ICAM-1 was observed in 12 out of 34 (35%) tumour specimens and de novo expression of HLA-DR (HLA class II) by carcinoma cells in 13 out of 34 (38%) cases. Aberrant expression of HLA class I antigens was frequently observed in cases in which MAGE genes and p53 overexpression were detected. The altered expression of these immunomodulatory molecules in HNSCC may affect prognosis and has important implications for peptide-based immunotherapy strategies for these patients

Are survival and mortality rates associated with recruitment to clinical trials in teenage and young adult patients with acute lymphoblastic leukaemia? A retrospective observational analysis in England

Objective: Participation rates in clinical trials are low in teenagers and young adults (TYA) with cancer. Whilst the importance of clinical trials in informing best practice is well established, data regarding individual patient benefit are scarce. We have investigated the association between overall survival and trial recruitment in TYA patients with acute lymphoblastic leukaemia (ALL). Design: Retrospective. Setting: National (England) TYA patients treated for ALL. Participants: 511 patients aged 15–24 years diagnosed with ALL between 2004 and 2010 inclusive, of whom 239 (46.7%) participated in the UKALL2003 trial. Outcome measures: Patients were identified using National Clinical Trial (UKALL2003) and Cancer Registry (National Cancer Data Repository, English National Cancer Online Registration Environment) Databases. Relative survival rates were calculated for trial and non-trial patients and observed differences were modelled using a multiple regression approach. The numbers and percentages of deaths in those patients included in the survival analysis were determined for each 3-month period, p values were calculated using the two-tailed z-test for difference between proportions and 95% CIs for percentage deaths were derived using the binomial distribution based on the Wilson Score method. Results: Patients treated on the trial had a 17.9% better 2-year survival (85.4% vs 67.5%, p<0.001) and 8.9% better 1-year survival (90.8% vs 81.9%, p=0.004) than those not on the trial. 35 (14.6%) patients recruited to the trial died in the 2 years following diagnosis compared with 86 (32.6%) of those not recruited (p<0.001). Conclusions: TYA patients recruited to the clinical trial UKALL 2003 in England had a lower risk of mortality and a higher overall survival than contemporaneous non-trial patients. These data underline the potential for individual patient benefit in participating in a clinical trial and the importance of international efforts to increase trial participation in the TYA age group. Trial registration number: ISRCTN07355119