127 research outputs found
Granulocytic Sarcoma in a Nonleukemic Patient: Place of Radiotherapy and Systemic Therapies
Granulocytic sarcoma is a rare extramedullary tumour, which most often occurs in the course of an acute or chronic leukaemia or myeloproliferative disorders. Rarely it is found before peripheral blood or bone marrow evidence of leukemia is present. We report an unusual case of acute paraplegia at first presentation of a spinal epidural granulocytic sarcoma without any haematological disorder. Therapeutic strategies are discussed in the light of the literature
Articulation and growth of skeletal elements in balanid barnacles (Balanidae, Balanomorpha, Cirripedia)
The morphology and ultrastructure of the shells of two balanid
species have been examined, paying special attention to the
three types of boundaries between plates: (i) radii-parietes, (ii)
alae-sheaths, and (iii) parietes-basal plate. At the carinal
surfaces of the radii and at the rostral surfaces of the alae, there
are series of crenulations with dendritic edges. The crenulations
of the radius margins interlock with less prominent features
of the opposing paries margins, whereas the surfaces of the
longitudinal abutments opposing the ala margins are
particularly smooth. The primary septa of the parietes also
develop dendritic edges, which abut the internal surfaces of
the primary tubes of the base plates. In all cases, there are
chitino-proteinaceous organic membranes between the abutting
structures. Our observations indicate that the very edges of the
crenulations and the primary septa are permanently in contact
with the organic membranes. We conclude that, when a new
growth increment is going to be produced, the edges of both
the crenulations and the primary septa pull the viscoelastic
organic membranes locally, with the consequent formation of
viscous fingers. For the abutting edges to grow, calcium
carbonate must diffuse across the organic membranes, but it is
not clear how growth of the organic membranes themselves is
accomplished, in the absence of any cellular tissue.This research was funded by projects CGL2017-85118-P (A.G.C., C.S. and C.G.) and CGL2015-64683-P (A.B.R.N.)
of the Spanish Ministerio de Economía, Industria y Competitividad, the Unidad Científica de Excelencia UCE-PP2016-05
of the University of Granada (A.G.C. and A.B.R.N.) and the Research Group RNM363 of the Junta de Andalucía
(A.G.C.). N.A.L. acknowledges support from CONICYT-Chile through grant nos. FONDECYT 1140938, PCI REDES
170106 and PIA ANILLOS ACT172037, for international collaborative research with A.G.C. and A.B.R.N
European Strategy for Particle Physics -- Accelerator R&D Roadmap
The 2020 update of the European Strategy for Particle Physics emphasised the
importance of an intensified and well-coordinated programme of accelerator R&D,
supporting the design and delivery of future particle accelerators in a timely,
affordable and sustainable way. This report sets out a roadmap for European
accelerator R&D for the next five to ten years, covering five topical areas
identified in the Strategy update. The R&D objectives include: improvement of
the performance and cost-performance of magnet and radio-frequency acceleration
systems; investigations of the potential of laser / plasma acceleration and
energy-recovery linac techniques; and development of new concepts for muon
beams and muon colliders. The goal of the roadmap is to document the collective
view of the field on the next steps for the R&D programme, and to provide the
evidence base to support subsequent decisions on prioritisation, resourcing and
implementation.Comment: 270 pages, 58 figures. Editor: N. Mounet. LDG chair: D. Newbold.
Panel chairs: P. V\'edrine (HFM), S. Bousson (RF), R. Assmann (plasma), D.
Schulte (muon), M. Klein (ERL). Panel editors: B. Baudouy (HFM), L. Bottura
(HFM), S. Bousson (RF), G. Burt (RF), R. Assmann (plasma), E. Gschwendtner
(plasma), R. Ischebeck (plasma), C. Rogers (muon), D. Schulte (muon), M.
Klein (ERL
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