Reconciling the stratigraphy and depositional history of the Lycian orogen-top basins, SW Anatolia

Terrestrial fossil records from the SWAnatolian basins are crucial both for regional correlations and palaeoenvironmental reconstructions. By reassessing biostratigraphic constraints and incorporating new fossil data, we calibrated and reconstructed the late Neogene andQuaternary palaeoenvironments within a regional palaeogeographical framework. The culmination of the Taurides inSWAnatolia was followed by a regional crustal extension from the late Tortonian onwards that created a broad array of NE-trending orogen-top basins with synchronic associations of alluvial fan, fluvial and lacustrine deposits. The terrestrial basins are superimposed on the upper Burdigalian marine units with a c. 7 myr of hiatus that corresponds to a shift from regional shortening to extension. The initial infill of these basins is documented by a transition from marginal alluvial fans and axial fluvial systems into central shallow-perennial lakes coinciding with a climatic shift from warm/humid to arid conditions. The basal alluvial fan deposits abound in fossil macro-mammals of an early Turolian (MN11–12; late Tortonian) age. The Pliocene epoch in the region was punctuated by subhumid/humid conditions resulting in a rise of local base levels and expansion of lakes as evidenced by marsh-swamp deposits containing diverse fossilmammal assemblages indicating late Ruscinian (lateMN15; late Zanclean) ageWe are grateful for the support of the international bilateral project between The Scientific and Technological Research Council of Turkey (TUBITAK) and The Russian Scientific Foundation (RFBR) with grant a number of 111Y192. M.C.A. is grateful to the Turkish Academy of Sciences (TUBA) for a GEBIP (Young Scientist Award) grant. T.K. and S.M. are grateful to the Ege University Scientific Research Center for the TTM/002/2016 and TTM/001/2016 projects. M.C.A., H.A., S.M. and M.B. have obtained Martin and Temmick Fellowships at Naturalis Biodiversity Center (Leiden). F.A.D. is supported by a Mehmet Akif Ersoy University Scientific Research Grant. T.A.N. is supported by an Alexander-von-Humboldt Scholarship. L.H.O. received support from TUBITAK under the 2221 program for visiting scientists

Silver nanoparticle/capecitabine for breast cancer cell treatment

© 2019This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells

A 2800-year multi-proxy sedimentary record of climate change from Lake Cubuk (Goynuk, Bolu, NW Anatolia)

The sediment of Lake Çubuk in NW Anatolia, which is situated very close to the climate boundary between the dry Central Anatolia and the wet Marmara region, is regarded as a suitable climate archive to test inward and outward movements of this boundary in accordance with past climate variations. Herein, we study the stratigraphic record of the last 2800 years of this landslide-dammed lake at 1030 m elevation, using multi-proxy tools (sedimentology, major and trace element geochemistry, stable isotopes, pollen, diatoms and ostracods) and compare the results with other contemporaneous Anatolian climatic records. Our findings indicate that Lake Çubuk recorded seven distinct climatic periods in the last 2800 years that have been previously revealed elsewhere in Anatolia. The most arid period occurred at the end of the Near-East Aridification Phase at approximately 200 BC when the δ18O shifted to very negative values, and the planktonic diatom ratio considerably decreased. The Dark Ages and the late Byzantine periods between AD 670 and 1070 are characterized by more positive δ18O values, increasingly higher lake levels and the most extensive arboreal cover of the entire record. The ‘Little Ice Age’ appeared suddenly, within 40 years, at AD 1350 and is reflected in all of the proxies, including a positive shift in δ18O, a sharp decrease in pollen of shrub and herb to the benefit of pine trees and a rapid increase in benthic diatom abundance indicating a lake level shallowing. In many parts of the record, a close match between the stable isotopes and the pollen assemblage zones in the last 2800 years demonstrates that climate rather than human activity was the primary driver of vegetation cover in this mid-altitude mountain of NW Anatolia.This study was financially supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK) with the project (no. 109Y353) entitled ‘Paleoclimatic Investigation of Çubuk Lake (Bolu, NW Anatolia) by Sedimentological, Geochemical and Paleo-ecological Tools’. The Commission for Scientific Research Projects of Eskişehir Osmangazi University also financially contributed to this study with the project numbered 200915009