56 research outputs found
Nationwide introduction of a new competency framework for undergraduate medical curricula: a collaborative approach.
Switzerland recently introduced PROFILES, a revised version of its national outcomes reference framework for the undergraduate medical curriculum. PROFILES is based on a set of competencies adapted from the CanMEDS framework and nine entrustable professional activities (EPAs) that students have to be able to perform autonomously in the context of a predefined list of clinical situations. The nationwide implementation of such a competency- and EPA-based approach to medical education is a complex process that represents an important change to the organisation of undergraduate training in the various medical schools. At the same time, the concepts underlying PROFILES also have to be reflected at the level of the Federal Licencing Examination (FLE) and the national accreditation process. The vice-deans for education mandated a Swiss Working Group for PROFILES Implementation (SWGPI) to elaborate a guide presenting the principles and best practices based on the current scientific literature, to ensure the coherence between the future developments of the medical curricula and the evolution of the FLE, and to propose a coordinated research agenda to evaluate the implementation process. On the basis of the literature and analysis of our national context, we determined the key elements important for a successful implementation. They can be grouped into several areas including curricular design and governance, the assessment system and entrustment process, faculty development and change management. We also identified two dimensions that will be of particular importance to create synergies and facilitate exchange between the medical schools: a systematic approach to curriculum mapping and the longitudinal integration of an e-portfolio to support the student learning process. The nationwide collaborative approach to define strategies and conditions for the implementation of a new reference framework has allowed to develop a shared understanding of the implications of PROFILES, to promote the establishment of Swiss mapping and e-portfolio communities, and to establish the conditions necessary for ensuring the continuous alignment of the FLE with the evolving medical curricula
Spectral weight transfer in a disorder-broadened Landau level
In the absence of disorder, the degeneracy of a Landau level (LL) is
, where is the magnetic field, is the area of the sample
and is the magnetic flux quantum. With disorder, localized states
appear at the top and bottom of the broadened LL, while states in the center of
the LL (the critical region) remain delocalized. This well-known phenomenology
is sufficient to explain most aspects of the Integer Quantum Hall Effect (IQHE)
[1]. One unnoticed issue is where the new states appear as the magnetic field
is increased. Here we demonstrate that they appear predominantly inside the
critical region. This leads to a certain ``spectral ordering'' of the localized
states that explains the stripes observed in measurements of the local inverse
compressibility [2-3], of two-terminal conductance [4], and of Hall and
longitudinal resistances [5] without invoking interactions as done in previous
work [6-8].Comment: 5 pages 3 figure
Robust Nodal Structure of Landau Level Wave Functions Revealed by Fourier Transform Scanning Tunneling Spectroscopy
Scanning tunneling spectroscopy is used to study the real-space local density
of states (LDOS) of a two-dimensional electron system in magnetic field, in
particular within higher Landau levels (LL). By Fourier transforming the LDOS,
we find a set of n radial minima at fixed momenta for the nth LL. The momenta
of the minima depend only on the inverse magnetic length. By comparison with
analytical theory and numerical simulations, we attribute the minima to the
nodes of the quantum cyclotron orbits, which decouple in Fourier representation
from the random guiding center motion due to the disorder. This robustness of
the nodal structure of LL wave functions should be viewed as a key property of
quantum Hall states
Non-perturbative dynamics of hot non-Abelian gauge fields: beyond leading log approximation
Many aspects of high-temperature gauge theories, such as the electroweak
baryon number violation rate, color conductivity, and the hard gluon damping
rate, have previously been understood only at leading logarithmic order (that
is, neglecting effects suppressed only by an inverse logarithm of the gauge
coupling). We discuss how to systematically go beyond leading logarithmic order
in the analysis of physical quantities. Specifically, we extend to
next-to-leading-log order (NLLO) the simple leading-log effective theory due to
Bodeker that describes non-perturbative color physics in hot non-Abelian
plasmas. A suitable scaling analysis is used to show that no new operators
enter the effective theory at next-to-leading-log order. However, a NLLO
calculation of the color conductivity is required, and we report the resulting
value. Our NLLO result for the color conductivity can be trivially combined
with previous numerical work by G. Moore to yield a NLLO result for the hot
electroweak baryon number violation rate.Comment: 20 pages, 1 figur
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged from a common ancestor roughly 100 million years ago and yet are almost indistinguishable by eye. They have the same chromosome number and genome sizes, and they occupy the same ecological niche. To explore the basis for this striking conservation of structure and function, we have sequenced the C. briggsae genome to a high-quality draft stage and compared it to the finished C. elegans sequence. We predict approximately 19,500 protein-coding genes in the C. briggsae genome, roughly the same as in C. elegans. Of these, 12,200 have clear C. elegans orthologs, a further 6,500 have one or more clearly detectable C. elegans homologs, and approximately 800 C. briggsae genes have no detectable matches in C. elegans. Almost all of the noncoding RNAs (ncRNAs) known are shared between the two species. The two genomes exhibit extensive colinearity, and the rate of divergence appears to be higher in the chromosomal arms than in the centers. Operons, a distinctive feature of C. elegans, are highly conserved in C. briggsae, with the arrangement of genes being preserved in 96% of cases. The difference in size between the C. briggsae (estimated at approximately 104 Mbp) and C. elegans (100.3 Mbp) genomes is almost entirely due to repetitive sequence, which accounts for 22.4% of the C. briggsae genome in contrast to 16.5% of the C. elegans genome. Few, if any, repeat families are shared, suggesting that most were acquired after the two species diverged or are undergoing rapid evolution. Coclustering the C. elegans and C. briggsae proteins reveals 2,169 protein families of two or more members. Most of these are shared between the two species, but some appear to be expanding or contracting, and there seem to be as many as several hundred novel C. briggsae gene families. The C. briggsae draft sequence will greatly improve the annotation of the C. elegans genome. Based on similarity to C. briggsae, we found strong evidence for 1,300 new C. elegans genes. In addition, comparisons of the two genomes will help to understand the evolutionary forces that mold nematode genomes
Unraveling quantum Hall breakdown in bilayer graphene with scanning gate microscopy
We use low-temperature scanning gate microscopy (SGM) to investigate the
breakdown of the quantum Hall regime in an exfoliated bilayer graphene flake.
SGM images captured during breakdown exhibit intricate patterns of "hotspots"
where the conductance is strongly affected by the presence of the tip. Our
results are well described by a model based on quantum percolation which
relates the points of high responsivity to tip-induced scattering between
localized Landau levels.Comment: 6 pages, 4 figure
Assembly and architecture of precursor nodes during fission yeast cytokinesis
Mapping of fission yeast precursor node interaction modules and assembly reveals important steps in contractile ring assembly
Multi-step approach for thermal optimization of 3D-IC and package
The move from 2D to 3D integration of digital electronic systems (e.g. a multiprocessor with memory) offers a great deal of advantages and is clearly the most promising option for designing future systems. However, the density of the heat dissipation spots is much higher in 3D systems. In the design of such systems, the temperature distribution of the whole system including the package solution must be consider and optimized. In this paper a common optimization approach for early (pathfinding) and later (floorplan) timing and thermal optimization is presented. The developed optimization engine can be used - with different inputs - for both steps (pathfinding and floorplanning). The developed flow is successfully applied to a 3D VLIW-processor
The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast.
Little is known about the mechanisms that establish the position of the division plane in eukaryotic cells. Wild-type fission yeast cells divide by forming a septum in the middle of the cell at the end of mitosis. Dmf1 mutants complete mitosis and initiate septum formation, but the septa that form are positioned at random locations and angles in the cell, rather than in the middle. We have cloned the dmf1 gene as a suppressor of the cdc7-24 mutant. The dmf1 mutant is allelic with mid1. The gene encodes a novel protein containing a putative nuclear localization signal, and a carboxy-terminal PH domain. In wild-type cells, Dmf1p is nuclear during interphase, and relocates to form a medial ring at the cell cortex coincident with the onset of mitosis. This relocalization occurs before formation of the actin ring and is associated with increased phosphorylation of Dmf1p. The Dmf1p ring can be formed in the absence of an actin ring, but depends on some of the genes required for actin ring formation. When the septum is completed and the cells separate, Dmf1p staining is once again nuclear. These data implicate Dmf1p as an important element in assuring correct placement of the division septum in Schizosaccharomyces pombe cells
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