Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe:the PanCareSurFup study

BACKGROUND: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort.METHODS: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940-2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated.RESULTS: In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia (SIR: 11.2, 95% CI: 8.8, 14.2) survivors were at greatest risk of glioma. The SIR for CNS tumour survivors was still 4.3-fold after age 50 (95% CI: 1.9, 9.6), and for leukaemia survivors still 10.2-fold after age 40 (95% CI: 4.9, 21.4). Following cranial radiotherapy (CRT), the cumulative incidence of a glioma in CNS tumour survivors was 2.7%, 3.7% and 5.0% by ages 40, 50 and 60, respectively, whilst for leukaemia this was 1.2% and 1.7% by ages 40 and 50. The cumulative incidence of a meningioma after CRT in CNS tumour survivors doubled from 5.9% to 12.5% between ages 40 and 60, and in leukaemia survivors increased from 5.8% to 10.2% between ages 40 and 50.DISCUSSION: Clinicians following up survivors should be aware that the substantial risks of meningioma and glioma following CRT are sustained beyond age 40 and be vigilant for symptoms.</p

The GALAH survey: tracing the Galactic disk with Open Clusters

Open clusters are unique tracers of the history of our own Galaxy's disk. According to our membership analysis based on \textit{Gaia} astrometry, out of the 226 potential clusters falling in the footprint of GALAH or APOGEE, we find that 205 have secure members that were observed by at least one of the survey. Furthermore, members of 134 clusters have high-quality spectroscopic data that we use to determine their chemical composition. We leverage this information to study the chemical distribution throughout the Galactic disk of 21 elements, from C to Eu. The radial metallicity gradient obtained from our analysis is $-$0.076$\pm$0.009 dex kpc$^{-1}$, which is in agreement with previous works based on smaller samples. Furthermore, the gradient in the [Fe/H] - guiding radius (r$_{\rm guid}$) plane is $-$0.073$\pm$0.008 dex kpc$^{-1}$. We show consistently that open clusters trace the distribution of chemical elements throughout the Galactic disk differently than field stars. In particular, at given radius, open clusters show an age-metallicity relation that has less scatter than field stars. As such scatter is often interpreted as an effect of radial migration, we suggest that these differences are due to the physical selection effect imposed by our Galaxy: clusters that would have migrated significantly also had higher chances to get destroyed. Finally, our results reveal trends in the [X/Fe]$-$r$_{\rm guid}$$-$age space, which are important to understand production rates of different elements as a function of space and time.Comment: 18 pages, 10 figures, accepted for publication MNRA

Itinéraire Méthodologique de Diagnostic Partagé des enjeux environnementaux. Comment accompagner le changement dans l'ingénierie territoriale d'Etat.

International audienc

Itinéraire Méthodologique de Diagnostic Partagé des enjeux environnementaux. Comment accompagner le changement dans l'ingénierie territoriale d'Etat.

International audienc

La méthode de diagnostic partagé : comprendre et analyser un territoire avec les représentations spatiales schématiques pour produire le « Dire de l’État »

4 page de la mallette pédagogique d’analyse territoriale, DREAL Poitou-Charente

La méthode de diagnostic partagé : comprendre et analyser un territoire avec les représentations spatiales schématiques pour produire le « Dire de l’État »

4 page de la mallette pédagogique d’analyse territoriale, DREAL Poitou-Charente

Structural and microwave properties of silica-coated NiFeMo flakes/polymer composites

International audienc

Characterization of ablated porcine bone and muscle using laser-induced acoustic wave method for tissue differentiation

A high power pulsed laser with millisecond pulse was used to interact with a bone and muscle of porcine, initiating an acoustic wave. We start to describe principle of laser ablation follows by the acoustic wave generation. Then, we present the characterization of these wave features for laser surgery applications