The Dugdale model for the compact specimen

Plastic zone size and crack tip opening displacement (CTOD) equations were developed. Boundary collocation analyses were used to analyze the compact specimen subjected to various loading conditions (pin loads, concentrated forces, and uniform pressure acting on the crack surface). Stress intensity factor and crack surface displacement equations for some of these loadings were developed and used to obtain the Dugdale model. The results from the equations for plastic zone size and CTOD agreed well with numerical values calculated by Terada for crack length to width ratios greater than 0.4

Using a treatment partner and text messaging to improve adherence to psychotropic medication: A qualitative formative study of service users and caregivers in Cape Town, South Africa

Objective: Poor adherence to medications, including psychotropic medications contributes to the burden of disease. Mental health service users (MHSU) may also not attend follow-up appointments at their health care facilities where they could discuss adherence with their health care provider. This paper reports on preliminary qualitative research preceding a randomised controlled trial that aims to improve adherence to psychotropic medication and to follow up treatment visits. The intervention will entail the support of individuals with serious mental disorder by a treatment partner and short message service (SMS) text messaging. Methods: The preliminary research reported in this paper aimed to extract views about the intervention from both mental health service users (MHSU) and caregivers through focus group discussions and individual interviews. Data were analysed using ATLAS TI qualitative software.Results: The caregivers interviewed were all mothers of MHSU who took measures to encourage adherence. They held mixed opinions on whether the treatment partner should be a family member. Most participants expressed the view that due to living conditions, family members were natural treatment partners, but others stated that they would prefer a treatment partner who was not a family member. Similarly, while most MHSU supported the idea of a treatment partner, a minority were concerned that a treatment partner may potentially be too controlling and compromise their autonomy. The vast majority of participants supported SMS text messaging as a means of reminding MHSU to take their medication and attend followup appointments. One participant mentioned the importance of broader social inclusion issues that should be  incorporated in the intervention.Conclusion: Qualitative research may provide useful insights for the design of interventions of this nature related to social inclusion randomised control trials with its focus on adherence.Keywords: Mental illness; Treatment partner; Social inclusion; Community care; Mobile phone

Turbulence and mixing by internal waves in the Celtic Sea determined from ocean glider microstructure measurements

We present a new series of data from a 9-day deployment of an ocean microstructure glider (OMG) in the Celtic Sea during the summer of 2012. The OMG has been specially adapted to measure shear microstructure and coincident density structure from which we derive the dissipation rate of turbulent kinetic energy (ε) and diapycnal diffusion rates (K). The methods employed to provide trustworthy turbulent parameters are described and data from 766 profiles of ε, temperature, salinity and density structure are presented. Surface and bottom boundary layers are intuitively controlled by wind and tidal forcing. Interior dynamics is dominated by a highly variable internal wave-field with peak vertical displacements in excess of 50 m, equivalent to over a third of the water depth. Following a relatively quiescent period internal wave energy, represented by the available potential energy (APE), increases dramatically close to the spring tide flow. Rather than follow the assumed spring-neap cycle however, APE is divided into two distinct peak periods lasting only one or two days. Pycnocline ε also increases close to the spring tide period and similar to APE, is distinguishable as two distinct energetic periods, however the timing of these periods is not consistent with APE. Pycnocline mixing associated with the observed ε is shown to be responsible for the majority of the observed reduction in bottom boundary layer density suggesting that diapycnal exchange is a key mechanism in controlling or limiting exchange between the continental shelf and the deep ocean. Results confirm pycnocline turbulence to be highly variable and difficult to predict however a log-normal distribution does suggest that natural variability could be reproduced if the mean state can be accurately simulated

Cohomology of bundles on homological Hopf manifold

We discuss the properties of complex manifolds having rational homology of $S^1 \times S^{2n-1}$ including those constructed by Hopf, Kodaira and Brieskorn-van de Ven. We extend certain previously known vanishing properties of cohomology of bundles on such manifolds.As an application we consider degeneration of Hodge-deRham spectral sequence in this non Kahler setting.Comment: To appear in Proceedings of 2007 conference on Several complex variables and Complex Geometry. Xiamen. Chin

Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

<p>Abstract</p> <p>Background</p> <p>Hyperactivity of the epithelial sodium (Na⁺) channel (ENaC) and increased Na⁺absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the pathogenesis of cystic fibrosis (CF) pulmonary disease. In airway epithelial cells, ENaC is constitutively activated by endogenous trypsin-like serine proteases such as Channel-Activating Proteases (CAPs). It was recently reported that ENaC activity could also be stimulated by apical treatment with human neutrophil elastase (hNE) in a human airway epithelial cell line, suggesting that hNE inhibition could represent a novel therapeutic approach for CF lung disease. However, whether hNE can also activate Na⁺reabsorption in primary human nasal epithelial cells (HNEC) from control or CF patients is currently unknown.</p> <p>Methods</p> <p>We evaluated by short-circuit current (<it>I</it>_sc) measurements the effects of hNE and EPI-hNE4, a specific hNE inhibitor, on ENaC activity in primary cultures of HNEC obtained from control (9) and CF (4) patients.</p> <p>Results</p> <p>Neither hNE nor EPI-hNE4 treatments did modify <it>I</it>_scin control and CF HNEC. Incubation with aprotinin, a Kunitz-type serine protease inhibitor that blocks the activity of endogenous CAPs, decreased <it>I</it>_scby 27.6% and 54% in control and CF HNEC, respectively. In control and CF HNEC pretreated with aprotinin, hNE did significantly stimulate <it>I</it>_sc, an effect which was blocked by EPI-hNE4.</p> <p>Conclusions</p> <p>These results indicate that hNE does activate ENaC and transepithelial Na⁺transport in both normal and CF HNEC, on condition that the activity of endogenous CAPs is first inhibited. The potent inhibitory effect of EPI-hNE4 on hNE-mediated ENaC activation observed in our experiments highlights that the use of EPI-hNE4 could be of interest to reduce ENaC hyperactivity in CF airways.</p

Guar -A nutrimental potent ethnomedicinal cultivated forage

ABSTRACT Bahraich U.P., India is blessed with diversified flora of more than 1200 plant species with Tharu tribals inhabiting inside as well as around the forests. The tribals have strong belief in magico therapeutic properties of plants for treatment of their ailments. The vegetation of the areas is mainly characterized by member of herbaceous plants growing on a variety of habitats along with scattered occurrence of many indigenous and exotic species of trees and shrubs in open areas or cultivated in gardens and along the road sides. The North Western Tarai belt in which Bahraich is situated is next to Himalaya which represents one of the thirty four hot spots of the World mega biodiversity. In spite of all, the wealth of traditional knowledge is being lost, as the traditional culture is gradually disappearing. Cyamopsis tetragonaloba (L.) Taub. belongs to Leguminosae, commonly known as cluster bean, guar, gvar, gwar or guwar bean, is an annual legume. This plant is cultivated for forage, to improve soil fertility, in mixed cropping as well as in crop rotation. It grows well in arid and semi arid soil, is drought tolerant and sun loving but susceptible to frost. There are a large number of health benefits of this bean. It is a good source of fiber protein and other nutrients. Lowers LDL bad cholesterols, improves heart health, and lowers risks of heart attack. The presence of fiber, folic acid and protein prevents heart complications. It improves haemoglobin, calcium and phosphorus strengthens bone. It has laxative property. It has low hypoglycemic property. It improves mental health, prevents birth defects in the foetus and vitamin K promotes foetal development. In addition it has a large industrial uses

Goal-neglect links Stroop interference with working memory capacity

Relationships between Stroop interference and working memory capacity may reflect individual differences in resolving conflict, susceptibility to goal neglect, or both of these factors. We compared relationships between working memory capacity and three Stroop tasks: a classic, printed color-word Stroop task, a cross-modal Stroop, and a new version of cross-modal Stroop with a concurrent auditory monitoring component. Each of these tasks showed evidence of interference between the semantic meaning of the color word and the to-be-named color, suggesting these tasks each require resolution of interference. However, only Stroop interference in the print-based task with high proportions of congruent trials correlated significantly with working memory capacity. This evidence suggests that the relationships observed between Stroop interference and working memory capacity are primarily driven by individual differences in the propensity to actively maintain a goal. (C) 2012 Elsevier B.V. All rights reserved