The European Large Area ISO Survey - ISOPHOT results using the MPIA-pipeline

The European Large Area ISO Survey (ELAIS) will provide Infrared observations of 4 regions in the sky with ISO. Around 2000 Infrared sources have been detected at 7 and 15 microns (with ISOCAM), 90 and 175 microns (with ISOPHOT)) over 13 square degrees of the sky. We present the source extraction pipeline of the 90 microns ISOPHOT observations, describe and discuss the results obtained and derive the limits of the ELAIS observational strategy.Comment: 4 pages, 5 figures, to appear in the ISO conference "The Universe as seen by ISO", 1998, UNESCO, Pari

High accuracy measure of atomic polarizability in an optical lattice clock

Despite being a canonical example of quantum mechanical perturbation theory, as well as one of the earliest observed spectroscopic shifts, the Stark effect contributes the largest source of uncertainty in a modern optical atomic clock through blackbody radiation. By employing an ultracold, trapped atomic ensemble and high stability optical clock, we characterize the quadratic Stark effect with unprecedented precision. We report the ytterbium optical clock's sensitivity to electric fields (such as blackbody radiation) as the differential static polarizability of the ground and excited clock levels: 36.2612(7) kHz (kV/cm)^{-2}. The clock's fractional uncertainty due to room temperature blackbody radiation is reduced an order of magnitude to 3 \times 10^{-17}.Comment: 5 pages, 3 figures, 2 table

An atomic clock with 10−1810^{-18} instability

Atomic clocks have been transformational in science and technology, leading to innovations such as global positioning, advanced communications, and tests of fundamental constant variation. Next-generation optical atomic clocks can extend the capability of these timekeepers, where researchers have long aspired toward measurement precision at 1 part in $\bm{10^{18}}$. This milestone will enable a second revolution of new timing applications such as relativistic geodesy, enhanced Earth- and space-based navigation and telescopy, and new tests on physics beyond the Standard Model. Here, we describe the development and operation of two optical lattice clocks, both utilizing spin-polarized, ultracold atomic ytterbium. A measurement comparing these systems demonstrates an unprecedented atomic clock instability of $\bm{1.6\times 10^{-18}}$ after only $\bm{7}$ hours of averaging

Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease

Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes (MW500Da). Materials and Methods: In 95 CKD-patients (CKD-stage 2-5 not on dialysis), associations between different eGFR-formulae (creatinine, CystatinC-based or both) and the natural logarithm of the concentration of several LMWP's were analyzed: i.e. parathyroid hormone (PTH), Cystatin C (CystC), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), leptin, retinol binding protein (RbP), immunoglobin light chains kappa and lambda (Ig-kappa and Ig-lambda), beta-2-microglobulin (beta M-2), myoglobin and fibroblast growth factor-23 (FGF-23)). Results: The regression coefficients (R-2) between eGFR, based on the CKD-EPI-Crea-CystC-formula as reference, and the examined LMWP's could be divided into three groups. Most of the LMWP's associated weakly (R-2 0.7). Almost identical R-2-values were found per LMWP for all eGFR-formulae, with exception of CystC and beta M-2 which showed weaker associations with creatinine-based than with CystC-based eGFR. Conclusion: The association between eGFR and the concentration of several LMWP's is inconsistent, with in general low R-2-values. Thus, the use of eGFR to evaluate kidney function does not reflect the concentration of several LMWP's with proven toxic impact in CKD

Hyper-Ramsey Spectroscopy of Optical Clock Transitions

We present non-standard optical Ramsey schemes that use pulses individually tailored in duration, phase, and frequency to cancel spurious frequency shifts related to the excitation itself. In particular, the field shifts and their uncertainties of Ramsey fringes can be radically suppressed (by 2-4 orders of magnitude) in comparison with the usual Ramsey method (using two equal pulses) as well as with single-pulse Rabi spectroscopy. Atom interferometers and optical clocks based on two-photon transitions, heavily forbidden transitions, or magnetically induced spectroscopy could significantly benefit from this method. In the latter case these frequency shifts can be suppressed considerably below a fractional level of 10^{-17}. Moreover, our approach opens the door for the high-precision optical clocks based on direct frequency comb spectroscopy.Comment: 5 pages, 4 figure

Sub-femtosecond absolute timing precision with a 10 GHz hybrid photonic-microwave oscillator

We present an optical-electronic approach to generating microwave signals with high spectral purity. By circumventing shot noise and operating near fundamental thermal limits, we demonstrate 10 GHz signals with an absolute timing jitter for a single hybrid oscillator of 420 attoseconds (1Hz - 5 GHz)

Determination of the cosmic far-infrared background level with the ISOPHOT instrument

The cosmic infrared background (CIRB) consists mainly of the integrated light of distant galaxies. In the far-infrared the current estimates of its surface brightness are based on the measurements of the COBE satellite. Independent confirmation of these results is still needed from other instruments. In this paper we derive estimates of the far-infrared CIRB using measurements made with the ISOPHOT instrument aboard the ISO satellite. The results are used to seek further confirmation of the CIRB levels that have been derived by various groups using the COBE data. We study three regions of very low cirrus emission. The surface brightness observed with the ISOPHOT instrument at 90, 150, and 180 um is correlated with hydrogen 21 cm line data from the Effelsberg radio telescope. Extrapolation to zero hydrogen column density gives an estimate for the sum of extragalactic signal plus zodiacal light. The zodiacal light is subtracted using ISOPHOT data at shorter wavelengths. Thus, the resulting estimate of the far-infrared CIRB is based on ISO measurements alone. In the range 150 to 180 um, we obtain a CIRB value of 1.08+-0.32+-0.30 MJy/sr quoting statistical and systematic errors separately. In the 90 um band, we obtain a 2-sigma upper limit of 2.3 MJy/sr. The estimates derived from ISOPHOT far-infrared maps are consistent with the earlier COBE results.Comment: Accepted for publication in A&A, 17 page

A Deep VLA survey at 20cm of the ISO ELAIS survey regions

We have used the Very Large Array(VLA) in C configuration to carry out a sensitive 20cm radio survey of regions of sky that have been surveyed in the Far Infra-Red over the wavelength range 5-200 microns with ISO as part of the European Large Area ISO Survey(ELAIS). As usual in surveys based on a relatively small number of overlapping VLA pointings the flux limit varies over the area surveyed. The survey has a flux limit that varies from a 5$\sigma$ limit of 0.135mJy over an area of 0.12deg$^2$ to a 5$\sigma$ limit of 1.15mJy or better over the whole region covered of 4.22 deg$^2$. In this paper we present the radio catalogue of 867 sources. These regions of sky have previously been surveyed to shallow flux limits at 20cm with the VLA as part of the VLA D configuration NVSS(FWHM=45 arcsec) and VLA B configuration FIRST(FWHM=5 arcsec) surveys. We have carried out a a detailed comparison of the reliability of our own survey and these two independent surveys in order to assess the reliability and completeness of each survey.Comment: 19 pages, 24 figures, submitted to MNRAS, also available in http://www.ast.cam.ac.uk/~ciliegi/elais/paper