258 research outputs found
Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
Scope
In vitro and in vivo studies suggest that dietary anthocyanins modulate cardiovascular disease risk; however, given anthocyanins extensive metabolism, it is likely that their degradation products and conjugated metabolites are responsible for this reported bioactivity.
Methods and results
Human vascular endothelial cells were stimulated with either oxidized LDL (oxLDL) or cluster of differentiation 40 ligand (CD40L) and cotreated with cyanidin-3-glucoside and 11 of its recently identified metabolites, at 0.1, 1, and 10 μM concentrations. Protein and gene expression of IL-6 and VCAM-1 was quantified by ELISA and RT-qPCR. In oxLDL-stimulated cells the parent anthocyanin had no effect on IL-6 production, whereas numerous anthocyanin metabolites significantly reduced IL-6 protein levels; phase II conjugates of protocatechuic acid produced the greatest effects (>75% reduction, p ≤ 0.05). In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p ≤ 0.03). Similarly, the anthocyanin and its metabolites reduced VCAM-1 protein production, with ferulic acid producing the greatest effect (>65% reduction, p ≤ 0.04).
Conclusion
These novel data provide evidence to suggest that anthocyanin metabolites are bioactive at physiologically relevant concentrations and have the potential to modulate cardiovascular disease progression by altering the expression of inflammatory mediators
Measurement of eta_c(1S), eta_c(2S) and non-resonant eta' pi+ pi- production via two-photon collisions
We report the measurement of gamma gamma to eta_c(1S), eta_c(2S) to eta' pi+
pi- with eta' decays to gamma rho and eta pi+ pi- using 941 fb^{-1} of data
collected with the Belle detector at the KEKB asymmetric-energy e+e- collider.
The eta_c(1S) mass and width are measured to be M = [2984.6\pm0.7 (stat.)\pm2.2
(syst.)] MeV/c^{2} and \Gamma = [30.8^{+2.3}_{-2.2}~(stat.) \pm 2.5~(syst.)]
MeV, respectively. First observation of eta_c(2S) to eta' pi+ pi- with a
significance of 5.5sigma including systematic error is obtained, and the
eta_c(2S) mass is measured to be M = [3635.1\pm3.7~(stat.)\pm2.9~(syst.)]
MeV/c^{2}. The products of the two-photon decay width and branching fraction
(B) of decays to eta'pi+ pi- are determined to be \Gamma_{gamma gamma}B =
[65.4\pm2.6~(stat.)\pm6.9~(syst.)] eV for eta_c(1S) and
[5.6^{+1.2}_{-1.1}~(stat.)\pm1.1~(syst.)] eV for eta_c(2S). A new decay mode
for the eta_c(1S) to eta'f_0(2080) with f_0(2080) to pi+ pi- is observed with a
statistical significance of 20sigma. The f_0(2080) mass and width are
determined to be M = [2083^{+63}_{-66}~(stat.)\pm 32~(syst.)] MeV/c^{2} and
\Gamma = [178^{+60}_{-178}~(stat.) \pm 55~(syst.)] MeV. The cross sections for
gamma gamma to eta' pi+ pi- and eta'f_{2}(1270) are measured for the first
time.Comment: 19 pages, 14 figure
Measurement of Branching Fractions of Hadronic Decays of the Baryon
Using a data sample of 980 of annihilation data
taken with the Belle detector operating at the KEKB asymmetric-energy
collider, we report the results of a study of the decays of the
charmed baryon into hadronic final states. We report the most precise
measurements to date of the relative branching fractions of the
into , , , and
, as well as the first measurements of the branching fractions
of the into , , and , all with respect to the decay. In
addition, we investigate the resonant substructure of these modes. Finally, we
present a limit on the branching fraction for the decay
Measurements of the absolute branching fractions of and at Belle
We present the measurement of the absolute branching fractions of and decays, using a
data sample of pairs collected at the
resonance with the Belle detector at the KEKB asymmetric-energy
collider. Here, denotes , ,
, , , , , ,
and . We do not observe significant signals for nor
, and set the 90 confidence level upper limits: and . These represent the most stringent upper limit for
to date and the first measurement for
. The measured branching fractions for
and are the most precise to date: and , where the first and
second uncertainties are statistical and systematic, respectively.Comment: 10 pages, 3 figure
Measurement of the lepton polarization and in the decay with one-prong hadronic decays at Belle
With the full data sample of pairs recorded by
the Belle detector at the KEKB electron-positron collider, the decay is studied with the hadronic
decays and . The polarization in two-body hadronic
decays is measured, as well as the ratio of the branching fractions , where
denotes an electron or a muon. Our results, and , are consistent with the theoretical
predictions of the Standard Model. The polarization values of are excluded at the 90\% confidence level.Comment: 17 pages, 11 figures, submitted to Physical Review
Inclusive study of bottomonium production in association with an meson in annihilations near
We study bottomonium production in association with an meson in
annihilations near the , at a center of mass energy of
GeV. The results are based on the fb data
sample collected by the Belle experiment at the asymmetric energy KEKB
collider. Only the meson is reconstructed and the missing-mass spectrum
of candidates is investigated. We observe the
process and find evidence for the
process, while no significant signals of
, , nor are found. Cross sections for the
studied processes are reported.Comment: Submitted to EPJ-
Evidence for Isospin Violation and Measurement of Asymmetries in
We report the first evidence for isospin violation in and
the first measurement of difference of asymmetries between and . This analysis is based on the data sample
containing pairs that was collected with the Belle
detector at the KEKB energy-asymmetric collider. We find evidence for
the isospin violation with a significance of 3.1, \%, where
the third uncertainty is due to the uncertainty on the fraction of to
production in decays. The measured value is
consistent with predictions of the SM. The result for the difference of
asymmetries is \%, consistent with zero. The measured branching fractions and
asymmetries for charged and neutral meson decays are the most precise to
date. We also calculate the ratio of branching fractions of to .Comment: 11 pages, 7 figures. shown at FPCP2017. accepted by PR
New Zealand blackcurrant extract enhances fat oxidation during prolonged cycling in endurance-trained females.
PURPOSE: New Zealand blackcurrant (NZBC) extract has previously been shown to increase fat oxidation during prolonged exercise, but this observation is limited to males. We examined whether NZBC intake also increases fat oxidation during prolonged exercise in females, and whether this was related to greater concentrations of circulating fatty acids. METHODS: In a randomised, crossover, double-blind design, 16 endurance-trained females (age: 28 ± 8 years, BMI: 21.3 ± 2.1 kg·m-2, VO2max: 43.7 ± 1.1 ml·kg-1·min-1) ingested 600 mg·day-1NZBC extract (CurraNZ™) or placebo (600 mg·day-1microcrystalline cellulose) for 7 days. On day 7, participants performed 120 min cycling at 65% VO2max, using online expired air sampling with blood samples collected at baseline and at 15 min intervals throughout exercise for analysis of glucose, NEFA and glycerol. RESULTS: NZBC extract increased mean fat oxidation by 27% during 120 min moderate-intensity cycling compared to placebo (P = 0.042), and mean carbohydrate oxidation tended to be lower (P = 0.063). Pre-exercise, plasma NEFA (P = 0.034) and glycerol (P = 0.051) concentrations were greater following NZBC intake, although there was no difference between conditions in the exercise-induced increase in plasma NEFA and glycerol concentrations (P > 0.05). Mean fat oxidation during exercise was moderately associated with pre-exercise plasma NEFA concentrations (r = 0.45, P = 0.016). CONCLUSIONS: Intake of NZBC extract for 7 days elevated resting concentrations of plasma NEFA and glycerol, indicative of higher lipolytic rates, and this may underpin the observed increase in fat oxidation during prolonged cycling in endurance-trained females
Search for light tetraquark states in ϒ(1S) and ϒ(2S) decays
We search for the JPC=0−− and 1+− light tetraquark states with masses up to 2.46 GeV/c2 in Υ(1S) and Υ(2S) decays with data samples of (102±2) million and (158±4) million events, respectively, collected with the Belle detector. No significant signals are observed in any of the studied production modes, and 90% credibility level (C.L.) upper limits on their branching fractions in Υ(1S) and Υ(2S) decays are obtained. The inclusive branching fractions of the Υ(1S) and Υ(2S) decays into final states with f1(1285) are measured to be B(Υ(1S)→f1(1285)+anything)=(46±28(stat)±13(syst))×10−4 and B(Υ(2S)→f1(1285)+anything)=(22±15(stat)±6.3(syst))×10−4. The measured χb2→J/ψ+anything branching fraction is measured to be (1.50±0.34(stat)±0.22(syst))×10−3, and 90% C.L. upper limits for the χb0,b1→J/ψ+anything branching fractions are found to be 2.3×10−3 and 1.1×10−3, respectively. For B(χb1→ω+anything), the branching fraction is measured to be (4.9±1.3(stat)±0.6(syst))×10−2. All results reported here are the firs
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