209 research outputs found

    Analytic continuation of residue currents

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    Let XX be a complex manifold and f\colon X\to \C^p a holomorphic mapping defining a complete intersection. We prove that the iterated Mellin transform of the residue integral associated to ff has an analytic continuation to a neighborhood of the origin in \C^p

    Banach Analytic Sets and a Non-Linear Version of the Levi Extension Theorem

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    We prove a certain non-linear version of the Levi extension theorem for meromorphic functions. This means that the meromorphic function in question is supposed to be extendable along a sequence of complex curves, which are arbitrary, not necessarily straight lines. Moreover, these curves are not supposed to belong to any finite dimensional analytic family. The conclusion of our theorem is that nevertheless the function in question meromorphically extends along an (infinite dimensional) analytic family of complex curves and its domain of existence is a pinched domain filled in by this analytic family.Comment: 19 pages, This is the final version with significant corrections and improvements. To appear in Arkiv f\"or matemati

    Differential Forms on Log Canonical Spaces

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    The present paper is concerned with differential forms on log canonical varieties. It is shown that any p-form defined on the smooth locus of a variety with canonical or klt singularities extends regularly to any resolution of singularities. In fact, a much more general theorem for log canonical pairs is established. The proof relies on vanishing theorems for log canonical varieties and on methods of the minimal model program. In addition, a theory of differential forms on dlt pairs is developed. It is shown that many of the fundamental theorems and techniques known for sheaves of logarithmic differentials on smooth varieties also hold in the dlt setting. Immediate applications include the existence of a pull-back map for reflexive differentials, generalisations of Bogomolov-Sommese type vanishing results, and a positive answer to the Lipman-Zariski conjecture for klt spaces.Comment: 72 pages, 6 figures. A shortened version of this paper has appeared in Publications math\'ematiques de l'IH\'ES. The final publication is available at http://www.springerlink.co

    Protocol for evaluating a workplace intervention within the framework of consultations for suffering at work in French-speaking Switzerland.

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    Psychosocial suffering involves diverse human, social and economic costs. Some 34.4% of workers in Switzerland report chronic stress related to their jobs. Medical consultations for suffering at work aim to maintain-or renew-patients' abilities to make decisions and act following a diagnosis of psychological suffering related to their work; they also aim to help workers return to their workstations or remain there. Workplace interventions by consulting occupational physicians can go beyond the subjective issues: they can be offered to employees, in anticipation of a return to work when this appears feasible from the outset. To qualitatively evaluate perceptions of workplace interventions and identify their effects by collecting the verbatim statements of employees and their employers. Qualitative single-centre study of workplace interventions conducted by the Consultation Service for Suffering at Work's occupational physicians for patients seen between January 2015 to December 2017. Nineteen workplace interventions took place, out of 184 different consultations. The verbatim statements of employees and their employers will be collected over a variable timeframe, using semi-structured face-to-face interviews. These will then be recorded, transcribed and analysed. Fourteen patients refused the workplace intervention. Their professional path will be collected for comparison and exploratory purposes. This exploratory research project will provide a better understanding of the issues surrounding work-related psychological suffering and of which strategies support patients most effectively

    Molecular developmental evidence for a subcoxal origin of pleurites in insects and identity of the subcoxa in the gnathal appendages

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    This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The attached file is the published version of the article

    Evolution of Game Controllers: Toward the Support of Gamers with Physical Disabilities

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    Video games, as an entertaining media, dates back to the \u201850s and their hardware device underwent a long evolution starting from hand-made devices such as the \u201ccathode-ray tube amusement device\u201d up to the modern mass-produced consoles. This evolution has, of course, been accompanied by increasingly specialized interaction mechanisms. As of today, interaction with games is usually performed through industry-standard devices. These devices can be either general purpose (e.g., mouse and keyboard) or specific for gaming (e.g., a gamepad). Unfortunately, for marketing reasons, gaming interaction devices are not usually designed taking into consideration the requirements of gamers with physical disabilities. In this paper, we will offer a review of the evolution of gaming control devices with a specific attention to their use by players with physical disabilities in the upper limbs. After discussing the functionalities introduced by controllers designed for disabled players we will also propose an innovative game controller device. The proposed game controller is built around a touch screen interface which can be configured based on the user needs and will be accessible by gamers which are missing fingers or are lacking control in hands movement

    Transcriptional Responses of Arabidopsis thaliana during Wilt Disease Caused by the Soil-Borne Phytopathogenic Bacterium, Ralstonia solanacearum

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    Bacterial wilt is a common disease that causes severe yield and quality losses in many plants. In the present study, we used the model Ralstonia solanacearum-Arabidopsis thaliana pathosystem to study transcriptional changes associated with wilt disease development. Susceptible Col-5 plants and RRS1-R-containing resistant Nd-1 plants were root-inoculated with R. solanacearum strains harbouring or lacking the matching PopP2 avirulence gene. Gene expression was marginally affected in leaves during the early stages of infection. Major changes in transcript levels took place between 4 and 5 days after pathogen inoculation, at the onset of appearance of wilt symptoms. Up-regulated genes in diseased plants included ABA-, senescence- and basal resistance-associated genes. The influence of the plant genetic background on disease-associated gene expression is weak although some genes appeared to be specifically up-regulated in Nd-1 plants. Inactivation of some disease-associated genes led to alterations in the plant responses to a virulent strain of the pathogen. In contrast to other pathosystems, very little overlap in gene expression was detected between the early phases of the resistance response and the late stages of disease development. This observation may be explained by the fact that above-ground tissues were sampled for profiling whereas the bacteria were applied to root tissues

    Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance

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    <p>Abstract</p> <p>Background</p> <p>Edema in nephrotic syndrome results from renal retention of sodium and alteration of the permeability properties of capillaries. Nephrotic syndrome induced by puromycin aminonucleoside (PAN) in rats reproduces the biological and clinical signs of the human disease, and has been widely used to identify the cellular mechanisms of sodium retention. Unfortunately, mice do not develop nephrotic syndrome in response to PAN, and we still lack a good mouse model of the disease in which the genetic tools necessary for further characterizing the pathophysiological pathway could be used. Mouse resistance to PAN has been attributed to a defect in glomerular adenosine deaminase (ADA), which metabolizes PAN. We therefore attempted to develop a mouse line sensitive to PAN through induction of normal adenosine metabolism in their podocytes.</p> <p>Methods</p> <p>A mouse line expressing functional ADA under the control of the podocyte-specific podocin promoter was generated by transgenesis. The effect of PAN on urinary excretion of sodium and proteins was compared in rats and in mice over-expressing ADA and in littermates.</p> <p>Results</p> <p>We confirmed that expression of ADA mRNAs was much lower in wild type mouse than in rat glomerulus. Transgenic mice expressed ADA specifically in the glomerulus, and their ADA activity was of the same order of magnitude as in rats. Nonetheless, ADA transgenic mice remained insensitive to PAN treatment in terms of both proteinuria and sodium retention.</p> <p>Conclusions</p> <p>Along with previous results, this study shows that adenosine deaminase is necessary but not sufficient to confer PAN sensitivity to podocytes. ADA transgenic mice could be used as a background strain for further transgenesis.</p

    DC050

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    Barlet acknowledges receiving $151.20 from James Morrison, Deputy Quarter Master General, for transporting the Field Company General's baggage to several locations during the months of November and December of 1812 and January, February, March, and April of 1813
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