Going beyond the linear approximation in describing electron- phonon coupling: relevance for the Holstein model

Using the momentum average approximation we study the importance of adding higher-than-linear terms in the electron-phonon coupling on the properties of single polarons described by a generalized Holstein model. For medium and strong linear coupling, even small quadratic electron-phonon coupling terms are found to lead to very significant quantitative changes in the properties of the polaron, which cannot be captured by a linear Holstein Hamiltonian with renormalized parameters. We argue that the bi-polaron phase diagram is equally sensitive to addition of quadratic coupling terms if the linear coupling is large. These results suggest that the linear approximation is likely to be inappropriate to model systems with strong electron-phonon coupling, at least for low carrier concentrations.Comment: 6 pages, 4 figures Final version accepted into EP

Evaluation der potenziellen Regeneratschädigung bei der Kallusumformung nach Distraktionsosteogenese der Mandibula: Eine experimentelle Untersuchung am Tiermodell

Zusammenfassung: Ziel: Bei der Korrektur dreidimensionaler Deformitäten des Gesichtsskelettes mit der Distraktionsosteogenese werden Umformungsvorgänge des Regenerates einerseits als Bestandteil des Behandlungsplans, andererseits im Falle eines Verlustes der Kontrolle über den Distraktionsvektor vorgenommen. Die vorliegende Untersuchung hatte das Ziel, die Grenzen der Kallusmanipulation zu beurteilen. Dazu wurden die Auswirkungen komprimierender sowie dehnender Einflüsse am gleichen Regenerat untersucht. Material und Methode: Bei 15Beagle-Hunden wurde mit speziell angefertigten bidirektionalen Distraktoren eine lineare Distraktion von 10mm beidseits im Unterkieferwinkel vorgenommen. Der neu gebildete Kallus wurde in einem Schritt um 20° anguliert, was im vorliegenden Modell einer Verkürzung/Verlängerung von ca. 35% der Ausgangslänge des Regenerates gleichkommt. Die Position des Rotationszentrums erlaubte es, das Regenerat gleichzeitig zu komprimieren und zu dehnen. Die Auswirkungen dieser mechanischen Einflüsse auf die Ossifikation des Regenerates wurden nach 6 bzw. 13Wochen beurteilt und mit einer Kontrollgruppe, bei der lediglich eine lineare Distraktion durchgeführt worden war, verglichen. Ergebnisse: Die radiologischen und histologischen Untersuchungen ergaben keinen statisch signifikanten Unterschied zwischen dem komprimierten und gedehnten Regenerat. Es zeigten sich jedoch im gedehnten Sektor des Kallus Zonen unvollständiger Ossifikation nach 6-wöchiger Konsolidierungszeit. Unter stabilen Verhältnissen wurde die verzögerte Knochenheilung im weiteren Verlauf kompensiert und eine vollständige Ossifikation nach 13Wochen erreicht. Schlussfolgerung: Unter stabilen Verhältnissen kann ein durch Distraktion gebildetes frisches Regenerat in einem beträchtlichen Ausmaß umgeformt werden, ohne die knöcherne Heilung bleibend zu kompromittieren. Die Dehnung des Kallus kann jedoch zu einer Verzögerung oder dem Ausbleiben des Ossifikationsprozesses führen und sollte vermieden werden. Dies lässt sich durch eine Überkorrektur der Regeneratlänge oder durch eine graduelle Angulation während des Distraktionsvorgangs erreiche

Assessment of mood in aphasia following stroke: validation of the Dynamic Visual Analogue Mood Scales (D-VAMS)

OBJECTIVES: To validate a non-verbal self-report measure of mood - the Dynamic Visual Analogue Mood Scales (D-VAMS) - against the Hospital Anxiety and Depression Scale (HADS) and assess its suitability as an outcome measure or screening measure for depressed mood following stroke. DESIGN: Cross-sectional observational cohort study. PARTICIPANTS: Forty-six stroke survivors (24% with aphasia) recruited from online, from stroke clubs and via an NHS rehabilitation service. METHODS: A set of seven bipolar scales was developed enabling users to report mood by modifying facial expression images using a slider. Participants completed a tablet/computer task, reporting their mood on these scales mixed randomly with versions which used only words. The HADS was then completed, followed by a repeat run of the two versions in a different, random sequence. RESULTS: Exploratory factor analysis identified one factor consistent with pleasantness of mood accounting for 80% of the variance. Internal consistency of D-VAMS was high ( α = 0.95), and there was a high correlation between face-only D-VAMS scores and HADS total scores ( r = -0.80, P < 0.001), as well as HADS-D/HADS-A subscale scores ( r = -0.73, P < 0.001; r = -0.71, P < 0.001). D-VAMS showed good sensitivity and specificity against HADS, with means of 85%/77% (sensitivity/specificity) against the HADS-D and 80%/77% against the HADS-A across nine cut-offs. CONCLUSION: D-VAMS is a valid and reliable measure likely suitable for assessment of depressed mood in aphasia following stroke. Though D-VAMS performed well as a screening measure in this study sample, further study is needed in the acute stage post-stroke

Perceptions of Facial Expressions of Emotion in Autism Spectrum Disorders: Reading the “minds eye” Using Reverse Correlation

One of the “primary social deficits” of Autism Spectrum Disorders (ASDs) is understanding the emotions of others, yet current literature is inconclusive as to whether individuals with ASD perceive basic facial expressions of emotion differently from typically developed (TD) individuals [Simmons, et al. 2009, Vision Research, 49, 12705-2739] and, if so, which specific emotions are confused

Emotion classification in Parkinson's disease by higher-order spectra and power spectrum features using EEG signals: A comparative study

Deficits in the ability to process emotions characterize several neuropsychiatric disorders and are traits of Parkinson's disease (PD), and there is need for a method of quantifying emotion, which is currently performed by clinical diagnosis. Electroencephalogram (EEG) signals, being an activity of central nervous system (CNS), can reflect the underlying true emotional state of a person. This study applied machine-learning algorithms to categorize EEG emotional states in PD patients that would classify six basic emotions (happiness and sadness, fear, anger, surprise and disgust) in comparison with healthy controls (HC). Emotional EEG data were recorded from 20 PD patients and 20 healthy age-, education level- and sex-matched controls using multimodal (audio-visual) stimuli. The use of nonlinear features motivated by the higher-order spectra (HOS) has been reported to be a promising approach to classify the emotional states. In this work, we made the comparative study of the performance of k-nearest neighbor (kNN) and support vector machine (SVM) classifiers using the features derived from HOS and from the power spectrum. Analysis of variance (ANOVA) showed that power spectrum and HOS based features were statistically significant among the six emotional states (p < 0.0001). Classification results shows that using the selected HOS based features instead of power spectrum based features provided comparatively better accuracy for all the six classes with an overall accuracy of 70.10% ± 2.83% and 77.29% ± 1.73% for PD patients and HC in beta (13-30 Hz) band using SVM classifier. Besides, PD patients achieved less accuracy in the processing of negative emotions (sadness, fear, anger and disgust) than in processing of positive emotions (happiness, surprise) compared with HC. These results demonstrate the effectiveness of applying machine learning techniques to the classification of emotional states in PD patients in a user independent manner using EEG signals. The accuracy of the system can be improved by investigating the other HOS based features. This study might lead to a practical system for noninvasive assessment of the emotional impairments associated with neurological disorders

Detestable or marvelous? Neuroanatomical correlates of character judgments

As we learn new information about the social and moral behaviors of other people, we form and update character judgments of them, and this can profoundly influence how we regard and act towards others. In the study reported here, we capitalized on two interesting neurological patient populations where this process of complex “moral updating” may go awry: patients with bilateral damage to ventromedial prefrontal cortex (vmPFC) and patients with bilateral damage to hippocampus (HC). We predicted that vmPFC patients, who have impaired emotion processing, would exhibit reduced moral updating, and we also investigated how moral updating might be affected by severe declarative memory impairment in HC patients. The vmPFC, HC, and brain-damaged comparison (BDC) participants made moral judgments about unfamiliar persons before and after exposure to social scenarios depicting the persons engaged in morally good, bad, or neutral behaviors. In line with our prediction, the vmPFC group showed the least amount of change in moral judgments, and interestingly, the HC group showed the most amount of change. These results suggest that the vmPFC and hippocampus play critical but complementary roles in updating moral character judgments about others: the vmPFC may attribute emotional salience to moral information, whereas the hippocampus may provide necessary contextual information from which to make appropriate character judgments

The gray matter volume of the amygdala is correlated with the perception of melodic intervals: a voxel-based morphometry study

Music is not simply a series of organized pitches, rhythms, and timbres, it is capable of evoking emotions. In the present study, voxel-based morphometry (VBM) was employed to explore the neural basis that may link music to emotion. To do this, we identified the neuroanatomical correlates of the ability to extract pitch interval size in a music segment (i.e., interval perception) in a large population of healthy young adults (N = 264). Behaviorally, we found that interval perception was correlated with daily emotional experiences, indicating the intrinsic link between music and emotion. Neurally, and as expected, we found that interval perception was positively correlated with the gray matter volume (GMV) of the bilateral temporal cortex. More important, a larger GMV of the bilateral amygdala was associated with better interval perception, suggesting that the amygdala, which is the neural substrate of emotional processing, is also involved in music processing. In sum, our study provides one of first neuroanatomical evidence on the association between the amygdala and music, which contributes to our understanding of exactly how music evokes emotional responses