CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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Análisis funcional del utillaje laminar del neolítico antiguo de Castillejos de Montefrío (Granada)

[EN] Castillejos de Montefrío (Granada) is an openair site located on the South of the Iberian Peninsula. This settlement is one of the most important sites to understand the neolithization process and the development of first farming societies for several millennia. In this paper we present the results of the use-wear analyses made on a selection of the flint blades (most of them without retouch) from the Early Neolithic levels. Our purpose, through the Traceology, is to recognize some activities developed in the settlement and provide some information about the site function. The results obtained show the importance of this kind of tools and reveal some economical aspects of the first farmers communities settled down in this region.[ES] El asentamiento de Castillejos de Montefrío constituye un yacimiento de primer orden para poder comprender el proceso de neolitización y el desarrollo de las primeras comunidades agricultoras y pastoras a lo largo de varios milenios en el sur peninsular. Aunque son muchas las publicaciones y los proyectos de investigación que se han generado a partir de la evidencia arqueológica recogida en este asentamiento, en el presente trabajo mostramos los resultados del análisis traceológico realizado sobre conjunto significativo de láminas –fundamentalmente aquellas que sin estar retocadas presentan huellas de uso– documentado en los niveles pertenecientes cronológicamente al Neolítico Antiguo. La información obtenida de estos estudios revela la importancia de este tipo de utillaje, así como ciertos aspectos sobre las prácticas económicas de estas comunidades prehistóricasEl análisis traceológico presentado se ha realizado en el marco del proyecto ERC: AGRIWESTMED “Origins and spread of agriculture in the western Mediterranean region” (ERC-AdG-230561)Peer Reviewe

Assembling the Dead, Gathering the Living: Radiocarbon Dating and Bayesian Modelling for Copper Age Valencina de la Concepción (Seville, Spain)

The great site of Valencina de la Concepción, near Seville in the lower Guadalquivir valley of southwest Spain, is presented in the context of debate about the nature of Copper Age society in southern Iberia as a whole. Many aspects of the layout, use, character and development of Valencina remain unclear, just as there are major unresolved questions about the kind of society represented there and in southern Iberia, from the late fourth to the late third millennium cal BC. This paper discusses 178 radiocarbon dates, from 17 excavated sectors within the c. 450 ha site, making it the best dated in later Iberian prehistory as a whole. Dates are modelled in a Bayesian statistical framework. The resulting formal date estimates provide the basis for both a new epistemological approach to the site and a much more detailed narrative of its development than previously available. Beginning in the 32nd century cal BC, a long-lasting tradition of simple, mainly collective and often successive burial was established at the site. Mud-vaulted tholoi appear to belong to the 29th or 28th centuries cal BC; large stone-vaulted tholoi such as La Pastora appear to date later in the sequence. There is plenty of evidence for a wide range of other activity, but no clear sign of permanent, large-scale residence or public buildings or spaces. Results in general support a model of increasingly competitive but ultimately unstable social relations, through various phases of emergence, social competition, display and hierarchisation, and eventual decline, over a period of c. 900 years