One-loop central-emission vertex for two gluons in N = 4 super Yang-Mills theory

A necessary ingredient for extending the BFKL equation to next-to-next-to-leading logarithmic (NNLL) accuracy is the one-loop central emission vertex (CEV) for two gluons which are not strongly ordered in rapidity. Here we consider the one-loop six-gluon amplitude in $\mathcal{N}=4$ super Yang-Mills (SYM) theory in a central next-to-multi-Regge kinematic (NMRK) limit, we show that its dispersive part factorises in terms of the two-gluon CEV, and we use it to extract the one-loop two-gluon CEV for any helicity configuration within this theory. This is a component of the two-gluon CEV in QCD. Although computed in the NMRK limit, both the colour structure and the kinematic dependence of the two-gluon CEV capture much of the complexity of the six-gluon amplitudes in general kinematics. In fact, the transcendental functions of the latter can be conveniently written in terms of impact factors, trajectories, single-emission CEVs and a remainder, which is a function of the conformally invariant cross ratios which characterise the six-gluon amplitudes in planar $\mathcal{N}=4$ SYM. Finally, as expected, in the MRK limit the two-gluon CEV neatly factorises in terms of two single-emission CEVs.Comment: 85 pages, 13 figure

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Combined subleading high-energy logarithms and NLO accuracy for W production in association with multiple jets

Large logarithmic corrections in $\hat{s}/{p}_t^2$ lead to substantial variations in the perturbative predictions for inclusive W-plus-dijet processes at the Large Hadron Collider. This instability can be cured by summing the leading-logarithmic contributions in $\hat{s}/{p}_t^2$ to all orders in α$_{s}$. As expected though, leading logarithmic accuracy is insufficient to guarantee a suitable description in regions of phase space away from the high energy limit.We present (i) the first calculation of all partonic channels contributing at next-to-leading logarithmic order in W-boson production in association with at least two jets, and (ii) bin-by-bin matching to next-to-leading fixed-order accuracy. This new perturbative input is implemented in High Energy Jets, and systematically improves the description of available experimental data in regions of phase space which are formally subleading with respect to $\hat{s}/{p}_t^2$

Combined subleading high-energy logarithms and NLO accuracy for W production in association with multiple jets

Large logarithmic corrections in s^/p2t lead to substantial variations in the perturbative predictions for inclusive W-plus-dijet processes at the Large Hadron Collider. This instability can be cured by summing the leading-logarithmic contributions in s^/p2t to all orders in αs. As expected though, leading logarithmic accuracy is insufficient to guarantee a suitable description in regions of phase space away from the high energy limit. We present (i) the first calculation of all partonic channels contributing at next-to-leading logarithmic order in W-boson production in association with at least two jets, and (ii) bin-by-bin matching to next-to-leading fixed-order accuracy. This new perturbative input is implemented in High Energy Jets, and systematically improves the description of available experimental data in regions of phase space which are formally subleading with respect to s^/p2t

"Eu não preciso falar que eu sou branca, cara, eu sou Latina!" Ou a complexidade da identificação racial na ideologia de ativistas jovens (não)brancas "I do not have to say that I am white, man, I am Latina!" Or the complexity of racial identification in the ideology of (non)white, young, female activists

Neste artigo procuro explorar a complexidade do processo de formação da identidade racial de mulheres, jovens ativistas (não)brancas em São Paulo. Levando em conta a interação do indivíduo com o mundo social, distingue-se a identidade racial apropriada da atribuída e a identidade racial individual da coletiva. Isso requer atenção para o papel da posição social racial, com as subsequentes vantagens raciais, para os sentimentos da ativista neste processo e para a influência mútua da heterogeneidade de identidade racial, do deslocamento da identidade racial e, por conseguinte, do papel da formação de identidade como estratégia de ideologia e práxis ativista.<br>In this article, I explore the complexity of racial identity formation of (non)white, young, female activists in São Paulo. Taking into account the interaction of the individual with the social world, one must distinguish between appropriated and attributed racial identities, as well as individual and collective identities. This requires attention to the role of racial social position and its subsequent racial advantages, to the feelings of activists about this process, and to the mutual influence of the heterogeneity of racial identity, the displacement of racial identity and, consequently, the role of identity formation as a strategy of activist ideology and praxis