7 research outputs found
Conjugation between 3D and 2D aromaticity: does it really exist? The case of carborane-fused heterocycles
Although several synthesized icosahedral carborane fused 2D π-ring systems are known, and even considerable conjugation has been noted between them in some cases, the phenomenon itself is not fully understood. Based on the results of our computational study, it can be concluded that the 2D aromatic character of the fused (exo) five-membered ring is low, even in cases where significant conjugation was proposed in previous studies. Moreover, the carborane moiety constricts the bonding properties of the exo ring, thus prohibiting or promoting different Lewis resonance structures. These results will shed further light on the design and electronic modulation of new carborane-based materials
A new access to diazaphospholes via cycloaddition–cycloreversion reactions on triazaphospholes
A novel bis-CF3-substituted diazaphosphole was synthesized selectively from hexafluoro-2-butyne and a 3H-1,2,3,4-triazaphosphole derivative. The [4+2] cycloaddition and subsequent cycloreversion reaction under elimination of pivaloyl nitrile affords the product in high yield. The heterocycle coordinates via the phosphorus atom to a W(CO)5-fragment and shows stronger π-accepting properties than the triazaphosphole
Neuroscience needs Network Science
The brain is a complex system comprising a myriad of interacting elements,
posing significant challenges in understanding its structure, function, and
dynamics. Network science has emerged as a powerful tool for studying such
intricate systems, offering a framework for integrating multiscale data and
complexity. Here, we discuss the application of network science in the study of
the brain, addressing topics such as network models and metrics, the
connectome, and the role of dynamics in neural networks. We explore the
challenges and opportunities in integrating multiple data streams for
understanding the neural transitions from development to healthy function to
disease, and discuss the potential for collaboration between network science
and neuroscience communities. We underscore the importance of fostering
interdisciplinary opportunities through funding initiatives, workshops, and
conferences, as well as supporting students and postdoctoral fellows with
interests in both disciplines. By uniting the network science and neuroscience
communities, we can develop novel network-based methods tailored to neural
circuits, paving the way towards a deeper understanding of the brain and its
functions.Comment: 19 pages, 1 figure, 1 bo