A Super-Earth Transiting a Naked-Eye Star

We have detected transits of the innermost planet "e" orbiting 55 Cnc (V=6.0), based on two weeks of nearly continuous photometric monitoring with the MOST space telescope. The transits occur with the period (0.74 d) and phase that had been predicted by Dawson & Fabrycky, and with the expected duration and depth for the crossing of a Sun-like star by a hot super-Earth. Assuming the star's mass and radius to be 0.963_{-0.029}^{+0.051} M_sun and 0.943 +/- 0.010 R_sun, the planet's mass, radius, and mean density are 8.63 +/- 0.35 Mearth, 2.00 +/- 0.14 Rearth, and 5.9_{-1.1}^{+1.5} g/cm^3. The mean density is comparable to that of Earth, despite the greater mass and consequently greater compression of the interior of 55 Cnc e. This suggests a rock-iron composition supplemented by a significant mass of water, gas, or other light elements. Outside of transits, we detected a sinusoidal signal resembling the expected signal due to the changing illuminated phase of the planet, but with a full range (168 +/- 70 ppm) too large to be reflected light or thermal emission. This signal has no straightforward interpretation and should be checked with further observations. The host star of 55 Cnc e is brighter than that of any other known transiting planet, which will facilitate future investigations.Comment: ApJ Letters, in press (v3) Minor changes/clarifications; (v2) Revised after fixing an error in the data reduction pipeline; for details see http://web.mit.edu/~jwinn/www/55cnc_response.tx

Ethnographic Advocacy Against the Death Penalty

This article develops the concept of “ethnographic advocacy” to make sense of the humanizing, open‐ended knowledge practices involved in the defense of criminal defendants charged with capital murder. Drawing from anthropological fieldwork with well‐respected figures in the American capital defense bar, as well as my own professional experience as an investigator specializing in death penalty sentencing mitigation, I argue that effective advocacy for life occurs through qualitative knowledge practices that share notable methodological affinities with contemporary anthropological ethnography. The article concludes with a preliminary exploration of what the concept of ethnographic advocacy might reveal about academic anthropology\u27s own advocative engagements

We are playing football: Seeing the game on Panapompom, PNG

© Royal Anthropological Institute 2011.This article is about football, played by men from Panapompom in Papua New Guinea's Milne Bay province. Football is problematic not because it is culturally appropriated or modified, but rather because Panapompom desired accurately to reproduce the appearance of the international game. As such it questions conventional frames of reference. An interpretation in terms of culture obscures Panapompom interests in football: its globally recognizable character. It mattered profoundly that Panapompom people played football. Yet framing football as a universal sporting institution is equally inadequate, erasing the specific political project that was embedded in the game. Displacing the interpretative framings, I argue that football itself provides a context in which Panapompom people can judge themselves in relation to others, who are defined in terms of colonial and postcolonial discourses on ‘development’. Taking football as a contextualizing image, Panapompom people appear in distinctive ways in the field of relationships that it defines.ESR

Antitumour activity of pembrolizumab in advanced mucosal melanoma: a post-hoc analysis of KEYNOTE-001, 002, 006.

BackgroundMucosal melanoma is an aggressive melanoma with poor prognosis. We assessed efficacy of pembrolizumab in patients with advanced mucosal melanoma in KEYNOTE-001 (NCT01295827), -002 (NCT01704287), and -006 (NCT01866319).MethodsPatients received pembrolizumab 2 mg/kg every 3 weeks (Q3W) or 10 mg/kg Q2W or Q3W. Response was assessed by independent central review per RECIST v1.1.Results1567 patients were treated and 84 (5%) had mucosal melanoma. Fifty-one of 84 were ipilimumab-naive. In patients with mucosal melanoma, the objective response rate (ORR) was 19% (95% CI 11-29%), with median duration of response (DOR) of 27.6 months (range 1.1 + to 27.6). Median progression-free survival (PFS) was 2.8 months (95% CI 2.7-2.8), with median overall survival (OS) of 11.3 months (7.7-16.6). ORR was 22% (95% CI 11-35%) and 15% (95% CI 5-32%) in ipilimumab-naive and ipilimumab-treated patients.ConclusionPembrolizumab provides durable antitumour activity in patients with advanced mucosal melanoma regardless of prior ipilimumab

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma

Background: Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a 1-year overall survival of approximately 50% in patients with metastatic uveal melanoma. Data showing a proven overall survival benefit with a systemic treatment are lacking. Tebentafusp is a bispecific protein consisting of an affinity-enhanced T-cell receptor fused to an anti-CD3 effector that can redirect T cells to target glycoprotein 100-positive cells. Methods: In this open-label, phase 3 trial, we randomly assigned previously untreated HLA-A*02:01-positive patients with metastatic uveal melanoma in a 2:1 ratio to receive tebentafusp (tebentafusp group) or the investigator's choice of therapy with single-agent pembrolizumab, ipilimumab, or dacarbazine (control group), stratified according to the lactate dehydrogenase level. The primary end point was overall survival. Results: A total of 378 patients were randomly assigned to either the tebentafusp group (252 patients) or the control group (126 patients). Overall survival at 1 year was 73% in the tebentafusp group and 59% in the control group (hazard ratio for death, 0.51; 95% confidence interval [CI], 0.37 to 0.71; P<0.001) in the intention-to-treat population. Progression-free survival was also significantly higher in the tebentafusp group than in the control group (31% vs. 19% at 6 months; hazard ratio for disease progression or death, 0.73; 95% CI, 0.58 to 0.94; P = 0.01). The most common treatment-related adverse events in the tebentafusp group were cytokine-mediated events (due to T-cell activation) and skin-related events (due to glycoprotein 100-positive melanocytes), including rash (83%), pyrexia (76%), and pruritus (69%). These adverse events decreased in incidence and severity after the first three or four doses and infrequently led to discontinuation of the trial treatment (2%). No treatment-related deaths were reported. Conclusions: Treatment with tebentafusp resulted in longer overall survival than the control therapy among previously untreated patients with metastatic uveal melanoma. (Funded by Immunocore; ClinicalTrials.gov number, NCT03070392; EudraCT number, 2015-003153-18.)

Swirling astrophysical flows - efficient amplifiers of Alfven waves

We show that a helical shear flow of a magnetized plasma may serve as an efficient amplifier of Alfven waves. We find that even when the flow is purely ejectional (i.e., when no rotation is present) Alfven waves are amplified through the transient, shear-induced, algebraic amplification process. Series of transient amplifications, taking place sequentially along the flow, may result in a cascade amplification of these waves. However, when a flow is swirling or helical (i.e., some rotation is imposed on the plasma motion), Alfven waves become subject to new, much more powerful shear instabilities. In this case, depending on the type of differential rotation, both usual and parametric instabilities may appear. We claim that these phenomena may lead to the generation of large amplitude Alfven waves and the mechanism may account for the appearance of such waves in the solar atmosphere, in accretion-ejecion flows and in accretion columns. These processes may also serve as an important initial (linear and nonmodal) phase in the ultimate subcritical transition to MHD Alfvenic turbulence in various kinds of astrophysical shear flows.Comment: 12 pages, 11 figures, accepted for publication (25-11-02) in Astronomy and Astrophysic