Pre and post processing using the IBM 3277 display station graphics attachment (RPQ7H0284)

A graphical interactive procedure operating under TSO and utilizing two CRT display terminals is shown to be an effective means of accomplishing mesh generation, establishing boundary conditions, and reviewing graphic output for finite element analysis activity

In-Line-Test of Variability and Bit-Error-Rate of HfOx-Based Resistive Memory

Spatial and temporal variability of HfOx-based resistive random access memory (RRAM) are investigated for manufacturing and product designs. Manufacturing variability is characterized at different levels including lots, wafers, and chips. Bit-error-rate (BER) is proposed as a holistic parameter for the write cycle resistance statistics. Using the electrical in-line-test cycle data, a method is developed to derive BERs as functions of the design margin, to provide guidance for technology evaluation and product design. The proposed BER calculation can also be used in the off-line bench test and build-in-self-test (BIST) for adaptive error correction and for the other types of random access memories.Comment: 4 pages. Memory Workshop (IMW), 2015 IEEE Internationa

Some Performance Characteristics of Subsurface Gravel Wetlands for Stormwater Management

Subsurface gravel wetlands were originally purposed for wastewater treatment and more recently have been used for stormwater treatment as a green infrastructure technology. Systems are sized to hold the water quality volume above, and drain within 24–48 hours. Design guidance follows static sizing principles with very little hydraulic calculations, which has left a gap in hydraulic performance data. Data from 12 years of field monitoring of various systems constructed in the northeast United States is presented. These systems include fully-sized as well as undersized (hold less that the water quality volume). Hydraulics are controlled by a restrictive outlet. At the same time, this outlet also creates the wetland characteristics of the system. Pollutant removal efficiencies for common stormwater pollutants are some of the highest for green infrastructure systems, with a significant component being microbially-mediated in the low dissolved oxygen gravel layers. This is a book chapter published by the American Society of Civil Engineers in World Environmental and Water Resources Congress 2020: Emerging and Innovative Technologies and International Perspectives in 2020, available online: https://doi.org/10.1061/978078448294

Characteristic Relations for Quantum Matrices

General algebraic properties of the algebras of vector fields over quantum linear groups $GL_q(N)$ and $SL_q(N)$ are studied. These quantum algebras appears to be quite similar to the classical matrix algebra. In particular, quantum analogues of the characteristic polynomial and characteristic identity are obtained for them. The $q$-analogues of the Newton relations connecting two different generating sets of central elements of these algebras (the determinant-like and the trace-like ones) are derived. This allows one to express the $q$-determinant of quantized vector fields in terms of their $q$-traces.Comment: 11 pages, latex, an important reference [16] added

Transfer RNA-derived small RNAs in the cancer transcriptome

The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics. Molecular disruption to RNA polymerase assembly, chromatin remodelling and transcription factor binding through to RNA editing, splicing, post-transcriptional regulation and ribosome scanning can result in significant costs arising from genome instability. Cancer development is one example of when such disruption takes place. RNA silencing is a term used to describe the effects of post-transcriptional gene silencing mediated by a diverse set of small RNA molecules. Small RNAs are crucial for regulating gene expression and microguarding genome integrity.RNA silencing studies predominantly focus on small RNAs such as microRNAs, short-interfering RNAs and piwi-interacting RNAs. We describe an emerging renewal of inter-est in a‘larger’small RNA, the transfer RNA (tRNA).Precisely generated tRNA-derived small RNAs, named tRNA halves (tiRNAs) and tRNA fragments (tRFs), have been reported to be abundant with dysregulation associated with cancer. Transfection of tiRNAs inhibits protein translation by displacing eukaryotic initiation factors from messenger RNA (mRNA) and inaugurating stress granule formation.Knockdown of an overexpressed tRF inhibits cancer cell proliferation. Recovery of lacking tRFs prevents cancer metastasis. The dual oncogenic and tumour-suppressive role is typical of functional small RNAs. We review recent reports on tiRNA and tRF discovery and biogenesis, identification and analysis from next-generation sequencing data and a mechanistic animal study to demonstrate their physiological role in cancer biology. We propose tRNA-derived small RNA-mediated RNA silencing is an innate defence mechanism to prevent oncogenic translation. We expect that cancer cells are percipient to their ablated control of transcription and attempt to prevent loss of genome control through RNA silencing

Fermionic Coset, Critical Level W^(2)_4-Algebra and Higher Spins

The fermionic coset is a limit of the pure spinor formulation of the AdS5xS5 sigma model as well as a limit of a nonlinear topological A-model, introduced by Berkovits. We study the latter, especially its symmetries, and map them to higher spin algebras. We show the following. The linear A-model possesses affine \AKMSA{pgl}{4}{4}_0 symmetry at critical level and its \AKMSA{psl}{4}{4}_0 current-current perturbation is the nonlinear model. We find that the perturbation preserves $\mathcal{W}^{(2)}_4$-algebra symmetry at critical level. There is a topological algebra associated to \AKMSA{pgl}{4}{4}_0 with the properties that the perturbation is BRST-exact. Further, the BRST-cohomology contains world-sheet supersymmetric symplectic fermions and the non-trivial generators of the $\mathcal{W}^{(2)}_4$-algebra. The Zhu functor maps the linear model to a higher spin theory. We analyze its \SLSA{psl}{4}{4} action and find finite dimensional short multiplets.Comment: 25 page

Regular Conjugacy Classes in the Weyl Group and Integrable Hierarchies

Generalized KdV hierarchies associated by Drinfeld-Sokolov reduction to grade one regular semisimple elements from non-equivalent Heisenberg subalgebras of a loop algebra \G\otimes{\bf C}[\lambda,\lambda^{-1}] are studied. The graded Heisenberg subalgebras containing such elements are labelled by the regular conjugacy classes in the Weyl group {\bf W}(\G) of the simple Lie algebra \G. A representative w\in {\bf W}(\G) of a regular conjugacy class can be lifted to an inner automorphism of \G given by $\hat w=\exp\left(2i\pi {\rm ad I_0}/m\right)$, where $I_0$ is the defining vector of an $sl_2$ subalgebra of \G.The grading is then defined by the operator $d_{m,I_0}=m\lambda {d\over d\lambda} + {\rm ad} I_0$ and any grade one regular element $\Lambda$ from the Heisenberg subalgebra associated to $[w]$ takes the form $\Lambda = (C_+ +\lambda C_-)$, where $[I_0, C_-]=-(m-1) C_-$ and $C_+$ is included in an $sl_2$ subalgebra containing $I_0$. The largest eigenvalue of ${\rm ad}I_0$ is $(m-1)$ except for some cases in $F_4$, $E_{6,7,8}$. We explain how these Lie algebraic results follow from known results and apply them to construct integrable systems.If the largest ${\rm ad} I_0$ eigenvalue is $(m-1)$, then using any grade one regular element from the Heisenberg subalgebra associated to $[w]$ we can construct a KdV system possessing the standard \W-algebra defined by $I_0$ as its second Poisson bracket algebra. For \G a classical Lie algebra, we derive pseudo-differential Lax operators for those non-principal KdV systems that can be obtained as discrete reductions of KdV systems related to $gl_n$. Non-abelian Toda systems are also considered.Comment: 44 pages, ENSLAPP-L-493/94, substantial revision, SWAT-95-77. (use OLATEX (preferred) or LATEX

Can support workers from AgeUK deliver an intervention to support older people with anxiety and depression? A qualitative evaluation.

BACKGROUND: Anxiety and depression often co-exist. These disorders are under-diagnosed and under-treated, specifically among older people, and lead to increased use of health and social care services and raised mortality. Older people report a reluctance to present to their GP with depression or anxiety symptoms due to perceived stigma about mental health problems, lack of acceptable treatments and the prioritising of physical health problems. Third sector organisations, who work closely with older people in the community, are well-placed to provide additional support. We developed a brief intervention based on principles of Behavioural Activation, with encouragement to participate in a group activity, for delivery by Support Workers from AgeUK. The aim of the study was to examine whether this brief intervention could be delivered to older people with anxiety and/or depression, with sufficient fidelity, and whether this approach was acceptable to patients, GPs and AgeUK Support Workers. METHODS: Semi-structured interviews with older people with self-reported anxiety and/or depression (who received the intervention), Support Workers and GPs to assess acceptability of the intervention and impact on routine care. A constant comparative approach was used to analyse the data. Intervention sessions between Support Workers and older people were digitally recorded and reviewed by the research team to assess fidelity. RESULTS: The Support Workers delivered the intervention with fidelity; access to the training maual and ongoing supervision were important. Older people found the intervention acceptable and valued the one-to-one support they received; group activities suggested by Support Workers were not valued by all. GPs recognised the need for additional support for vulnerable older people, but acknowledged they could not provide this support. Participation in the study did not impact on GP routine care, other than responding to the calls from the study team about risk of self-harm. CONCLUSIONS: Support Workers within AgeUK, can be recruited and trained to deliver an intervention, based on the principles of Behavioural Activation, to older people with anxiety and/or depression. The training and supervision model used in the study was acceptable to Support Workers, and the intervention was acceptable to older people and GPs. This model has the potential to contribute to improving the support and care of older people in primary care with anxiety and depression. Further testing is required in a full trial. TRIAL REGISTRATION: Trial registration number ISRCTN16318986 . Registered 10/11/2016

Development and preliminary validation of a Greek-language outpatient satisfaction questionnaire with principal components and multi-trait analyses

BACKGROUND: In the recent years there is a growing interest in Greece concerning the measurement of the satisfaction of patients who are visiting the outpatient clinics of National Health System (NHS) general acute hospitals. The aim of this study is therefore to develop a patient satisfaction questionnaire and provide its preliminary validation. METHODS: A questionnaire in Greek has been developed by literature review, researchers' on the spot observation and interviews. Pretesting has been followed by telephone surveys in two short-term general NHS hospitals in Macedonia, Greece. A proportional stratified random sample of 285 subjects and a second random sample of 100 outpatients, drawn on March 2004, have been employed for the analysis. These have resulted in scale creation via Principal Components Analysis and psychometric testing for internal consistency, test-retest and interrater reliability as well as construct validity. RESULTS: Four summated scales have emerged regarding the pure outpatient component of the patients' visits, namely medical examination, hospital environment, comfort and appointment time. Cronbach's alpha coefficients and Pearson, Spearman and intraclass correlations indicate a high degree of scale reliability and validity. Two other scales -lab appointment time and lab experience- capture the apparently distinct yet complementary visitor experience related to the radiographic and laboratory tests. Psychometric tests are equally promising, however, some discriminant validity differences lack statistical significance. CONCLUSION: The instrument appears to be reliable and valid regarding the pure outpatient experience, whereas more research employing larger samples is required in order to establish the apparent psychometric properties of the complementary radiographic and laboratory-testing process, which is only relevant to about 25% of the subjects analysed here