Water and Sodium Regulation in Heart Failure

Heart failure is the pathophysiological state characterized by ventricular dysfunction and associated clinical symptoms. Decreased cardiac output or peripheral vascular resistance lead to arterial underfilling. That is an important signal which triggers multiple neurohormonal systems to maintain adequate arterial pressure and peripheral perfusion of the vital organs. The kidney is the principal organ affected when cardiac output declines. Alterations of hemodynamics and neurohormonal systems in heart failure result in renal sodium and water retention. Activation of sympathetic nervous system, renin-angiotensin-aldosterone system and non-osmotic vasopressin release stimulate the renal tubular reabsorption of sodium and water. Dysregulation of aquaporin-2 and sodium transporters also play an important role in the pathogenesis of renal sodium and water retention

S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development

S6 kinase localizes to the active zone in a Brp-dependent manner and collaborates with presynaptic PDK1 to modulate neuronal cell size, bouton size, active zone number, and neurotransmitter release

Letters of members of the Continental congress,

.--I. August 29, 1774 to July 4, 1776.--II. July 5, 1776 to December 31, 1777.--III. January 1 to December 31, 1778.--IV. January 1 to December 31, 1779.--V. January 1, 1780 to February 28, 1781.--VI. March 1, 1781 to December 31, 1782.--VII. January 1, 1783 to December 31, 1784.--VIII. January 1, 1785 to July 25, 1789 with supplement 1783-1784.Mode of access: Internet

Self-Efficacy as a Relevant Construct in Understanding Sexual Response and Dysfunction

While self-efficacy has been widely used to explain and treat various biobehavioral responses, few investigations have examined this concept in the context of sexual response and dysfunction. In this study, the authors constructed a measure of sexual self-efficacy, investigated whether it differentiated men with and without sexual dysfunction, and determined the utility of this construct by exploring its relation to other variables known to be related to erectile dysfunction in a sample of 60 men with erectile dysfunction and 14 functional men visiting a urology clinic. The sexual self-efficacy index differentiated men with and without erectile dysfunction, and general linear modeling showed that the index did indeed relate to other variables known to affect sexual and emotional response during a partnered sexual experience. These findings suggest that, as a unifying construct that predicts cognitive, affective, motivational, and behavioral responses, sexual self-efficacy has the potential to play an important role in the assessment of effective treatments for sexual problems