The Self Model and the Conception of Biological Identity in Immunology

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity

Optical and Radio Polarimetry of the M87 Jet at 0.2" Resolution

We discuss optical (HST/WFPC2 F555W) and radio (15 GHz VLA) polarimetry observations of the M87 jet taken during 1994-1995. Many knot regions are very highly polarized ($\sim 40-50$, approaching the theoretical maximum for optically thin synchrotron radiation), suggesting highly ordered magnetic fields. High degrees of polarization are also observed in interknot regions. While the optical and radio polarization maps share many similarities, we observe significant differences between the radio and optical polarized structures, particularly for bright knots in the inner jet, giving us important insight into the jet's radial structure. Unlike in the radio, the optical magnetic field position angle becomes perpendicular to the jet at the upstream ends of knots HST-1, D, E and F. Moreover, the optical polarization decreases markedly at the position of the flux maxima in these knots. In contrast, the magnetic field position angle observed in the radio remains parallel to the jet in most of these regions, and the decreases in radio polarization are smaller. More minor differences are seen in other jet regions. Many of the differences between optical and radio polarimetry results can be explained in terms of a model whereby shocks occur in the jet interior, where higher-energy electrons are concentrated and dominate both polarized and unpolarized emissions in the optical, while the radio maps show strong contributions from lower-energy electrons in regions with {\bf B} parallel, near the jet surface.Comment: 28 pages, 7 figures; accepted for publication in AJ (May 1999

Constraining the parameters of binary systems through time-dependent light deflection

A theory is derived relating the configuration of the cores of active galaxies, specifically candidates for presumed super-massive black hole binaries (SMBHBs), to time-dependent changes in images of those galaxies. Three deflection quantities, resulting from the monopole term, mass quadrupole term, and spin dipole term of the core, are examined. The resulting observational technique is applied to the galaxy 3C66B. This technique is found to under idealized circumstances surpass the technique proposed by Jenet et al. in accuracy for constraining the mass of SMBHB candidates, but is exceeded in accuracy and precision by Jenet's technique under currently-understood likely conditions. The technique can also under favorable circumstances produce results measurable by currently-available astronomical interferometry such as very-long baseline-interferometry (VLBI).Comment: 15 pages, 2 figures, accepted in General Relativity & Gravitatio

Randomly Evolving Idiotypic Networks: Structural Properties and Architecture

We consider a minimalistic dynamic model of the idiotypic network of B-lymphocytes. A network node represents a population of B-lymphocytes of the same specificity (idiotype), which is encoded by a bitstring. The links of the network connect nodes with complementary and nearly complementary bitstrings, allowing for a few mismatches. A node is occupied if a lymphocyte clone of the corresponding idiotype exists, otherwise it is empty. There is a continuous influx of new B-lymphocytes of random idiotype from the bone marrow. B-lymphocytes are stimulated by cross-linking their receptors with complementary structures. If there are too many complementary structures, steric hindrance prevents cross-linking. Stimulated cells proliferate and secrete antibodies of the same idiotype as their receptors, unstimulated lymphocytes die. Depending on few parameters, the autonomous system evolves randomly towards patterns of highly organized architecture, where the nodes can be classified into groups according to their statistical properties. We observe and describe analytically the building principles of these patterns, which allow to calculate number and size of the node groups and the number of links between them. The architecture of all patterns observed so far in simulations can be explained this way. A tool for real-time pattern identification is proposed.Comment: 19 pages, 15 figures, 4 table

Detection of Solar-like Oscillations in the G7 Giant Star xi Hya

We report the firm discovery of solar-like oscillations in a giant star. We monitored the star xi Hya (G7III) continuously during one month with the CORALIE spectrograph attached to the 1.2m Swiss Euler telescope. The 433 high-precision radial-velocity measurements clearly reveal multiple oscillation frequencies in the range 50 - 130 uHz, corresponding to periods between 2.0 and 5.5 hours. The amplitudes of the strongest modes are slightly smaller than 2 m/s. Current model calculations are compatible with the detected modes.Comment: 4 pages, 4 figures, accepted for publication as a letter in A&

Randomly Evolving Idiotypic Networks: Modular Mean Field Theory

We develop a modular mean field theory for a minimalistic model of the idiotypic network. The model comprises the random influx of new idiotypes and a deterministic selection. It describes the evolution of the idiotypic network towards complex modular architectures, the building principles of which are known. The nodes of the network can be classified into groups of nodes, the modules, which share statistical properties. Each node experiences only the mean influence of the groups to which it is linked. Given the size of the groups and linking between them the statistical properties such as mean occupation, mean life time, and mean number of occupied neighbors are calculated for a variety of patterns and compared with simulations. For a pattern which consists of pairs of occupied nodes correlations are taken into account.Comment: 14 pages, 8 figures, 4 table

Multifrequency Radiation of Extragalactic Large-Scale Jets

Large-scale extragalactic jets, observed to extend from a few to a few hundred kiloparsecs from active galactic nuclei, are now studied over many decades in frequency of electromagnetic spectrum, from radio until (possibly) TeV gamma rays. For hundreds of known radio jets, only about 25 are observed at optical frequencies. Most of them are relatively short and faint, with only a few exceptions, like 3C 273 or M 87, allowing for detailed spectroscopic and morphological studies. Somewhat surprisingly, the large-scale jets can be very prominent in X-rays. Up to now, about 25 jets were detected within the 1 - 10 keV energy range, although the nature of this emission is still under debate. In general, both optical and X-ray jet observations present serious problems for standard radiation models for the considered objects. Recent TeV observations of M 87 suggest the possibility of generating large photon fluxes at these high energies by its extended jet. In this paper we summarize information about multiwavelength emission of the large-scale jets, and we point out several modifications of the standard jet radiation models (connected with relativistic bulk velocities, jet radial stratification and particle energization all the way along the jet), which can possibly explain some of the mentioned puzzling observations. We also comment on gamma-ray emission of the discussed objects.Comment: 29 pages. Modified version, accepted for publication in Chinese Journal of Astronomy and Astrophysic

First AMBER/VLTI observations of hot massive stars

AMBER is the first near infrared focal instrument of the VLTI. It combines three telescopes and produces spectrally resolved interferometric measures. This paper discusses some preliminary results of the first scientific observations of AMBER with three Unit Telescopes at medium (1500) and high (12000) spectral resolution. We derive a first set of constraints on the structure of the circumstellar material around the Wolf Rayet Gamma2 Velorum and the LBV Eta Carinae

'Tipping the Balance': Karl Friedrich Meyer, Latent Infections, and the Birth of Modern Ideas of Disease Ecology

The Swiss-born medical researcher Karl Friedrich Meyer (1884–1974) is best known as a ‘microbe hunter’ who pioneered investigations into diseases at the intersection of animal and human health in California in the 1920s and 1930s. In particular, historians have singled out Meyer’s 1931 Ludwig Hektoen Lecture in which he described the animal kingdom as a ‘reservoir of disease’ as a forerunner of ‘one medicine’ approaches to emerging zoonoses. In so doing, however, historians risk overlooking Meyer’s other intellectual contributions. Developed in a series of papers from the mid-1930s onwards, these were ordered around the concept of latent infections and sought to link microbial behavior to broader bio-ecological, environmental, and social factors that impact hostpathogen interactions. In this respect Meyer—like the comparative pathologist Theobald Smith and the immunologist Frank Macfarlane Burnet—can be seen as a pioneer of modern ideas of disease ecology. However, while Burnet’s and Smith’s contributions to this scientific field have been widely acknowledged, Meyer’s have been largely ignored. Drawing on Meyer’s published writings and private correspondence, this paper aims to correct that lacuna while contributing to a reorientation of the historiography of bacteriological epidemiology. In particular I trace Meyer’s intellectual exchanges with Smith, Burnet and the animal ecologist Charles Elton, over brucellosis, psittacosis and plague—exchanges that not only showed how environmental and ecological conditions could ‘tip the balance’ in favor of parasites but which transformed Meyer thinking about resistance to infection and disease