Field-calibrated model of melt, refreezing, and runoff for polar ice caps : Application to Devon Ice Cap

Acknowledgments R.M.M. was supported by the Scottish Alliance for Geoscience, Environment and Society (SAGES). The field data collection contributed to the validation of the European Space Agency Cryosat mission and was supported by the Natural Sciences and Engineering Research Council, Canada, the Meteorological Service of Canada (CRYSYS program), the Polar Continental Shelf Project (an agency of Natural Resources Canada), and by UK Natural Environment Research Council consortium grant NER/O/S/2003/00620. Support for D.O.B. was provided by the Canadian Circumpolar Institute and the Climate Change Geoscience Program, Earth Sciences Sector, Natural Resources Canada (ESS contribution 20130371). Thanks are also due to the Nunavut Research Institute and the communities of Resolute Bay and Grise Fjord for permission to conduct fieldwork on Devon Ice Cap. M.J. Sharp, A. Gardner, F. Cawkwell, R. Bingham, S. Williamson, L. Colgan, J. Davis, B. Danielson, J. Sekerka, L. Gray, and J. Zheng are thanked for logistical support and field assistance during the data collection. We thank Ruzica Dadic, two other anonymous reviewers, and the Editor, Bryn Hubbard, for their helpful comments on an earlier version of this paper and which resulted in significant improvements.Peer reviewedPublisher PD

Forty-seven Years of Research on the Devon Island Ice Cap, Arctic Canada

The Devon Island ice cap has been the subject of scientific study for almost half a century, beginning with the first mass balance measurements in 1961. Research on the ice cap was the first to investigate (1) the role of meltwater in seasonal ice-velocity variations on a polythermal Arctic ice cap, (2) the use of air temperature rather than net radiation as a proxy for the energy driving surface melt, and (3) the influence of the changing frequency of specific synoptic weather configurations on glacier melt and mass balance. Other research has included investigations of ice cap geometry, flow dynamics, and mass balance; ice core analyses for records of past climate and contaminant deposition; and studies of changes in ice cap area and volume and their relationship to surface mass balance and ice dynamics. Current research includes ground studies connected to efforts to calibrate and validate the radar altimeter that will be carried by the European Space Agency’s (ESA) CryoSat2 satellite, and a major collaborative Canadian International Polar Year (IPY) project focused on the Belcher Glacier, on the northeast side of the ice cap, that examines hydrodynamics of large tidewater glaciers. This paper summarizes our current knowledge of the Devon Island ice cap and identifies some of the outstanding questions that continue to limit our understanding of climate-ice cap interactions in Arctic regions.La calotte glaciaire de l’île Devon fait l’objet d’une étude scientifique depuis près d’un demi-siècle, les premières mesures du bilan massique remontant à 1961. C’est la première fois que des travaux de recherche sur la calotte glaciaire permettent de faire enquête sur 1) le rôle de l’eau de fonte dans les variations caractérisant la vélocité de la glace d’une calotte glaciaire polytherme de l’Arctique; 2) l’utilisation de la température de l’air au lieu du bilan radiatif en surface en guise d’approximation pour la fonte superficielle conductrice d’énergie, et 3) l’influence exercée par la fréquence changeante de configurations climatiques synoptiques spécifiques sur la fonte du glacier et le bilan massique. Parmi les autres travaux de recherche, notons des enquêtes sur la géométrie de la calotte glaciaire, la dynamique des débits d’écoulement et le bilan massique; l’analyse des enregistrements relatifs aux carottes glaciaires en ce qui a trait à d’anciens dépôts climatiques et dépôts de contaminants; et l’étude des changements caractérisant l’aire et le volume de la calotte glaciaire de même que leur relation par rapport au bilan massique en surface et à la dynamique des glaces. Par ailleurs, les travaux de recherche actuels prennent la forme d’études sur le terrain se rapportant aux efforts visant à calibrer et à valider l’altimètre radar, études qui seront effectuées par le satellite CryoSat2 de l’Agence spatiale européenne (ASE), et un projet d’envergure en collaboration avec l’Année polaire internationale (API) au Canada portant sur le glacier Belcher, du côté nord-est de la carotte glaciaire, projet qui examine l’hydrodynamique des gros glaciers de marée. La présente communication résume nos connaissances actuelles de la calotte glaciaire de l’île Devon de même que certaines des questions en suspens qui continuent de restreindre la façon dont nous comprenons les interactions entre le climat et la calotte glaciaire dans les régions arctiques

Time-resolved photoionization spectroscopy of mixed Rydberg-valence states:indole case study

Time-resolved photoelectron imaging reveals subtle new mechanistic insight into the ultraviolet relaxation dynamics of gas-phase indole.</p

Multiple Inflation, Cosmic String Networks and the String Landscape

Motivated by the string landscape we examine scenarios for which inflation is a two-step process, with a comparatively short inflationary epoch near the string scale and a longer period at a much lower energy (like the TeV scale). We quantify the number of $e$-foldings of inflation which are required to yield successful inflation within this picture. The constraints are very sensitive to the equation of state during the epoch between the two inflationary periods, as the extra-horizon modes can come back inside the horizon and become reprocessed. We find that the number of $e$-foldings during the first inflationary epoch can be as small as 12, but only if the inter-inflationary period is dominated by a network of cosmic strings (such as might be produced if the initial inflationary period is due to the brane-antibrane mechanism). In this case a further 20 $e$-foldings of inflation would be required at lower energies to solve the late universe's flatness and horizon problems.Comment: 27 pages, 6 figures; v2: refences adde

Glacier velocities and dynamic ice discharge from the Queen Elizabeth Islands, Nunavut, Canada

Recent studies indicate an increase in glacier mass loss from the Canadian Arctic Archipelago as a result of warmer summer air temperatures. However, no complete assessment of dynamic ice discharge from this region exists. We present the first complete surface velocity mapping of all ice masses in the Queen Elizabeth Islands and show that these ice masses discharged ~2.6 ± 0.8 Gt a−1 of ice to the oceans in winter 2012. Approximately 50% of the dynamic discharge was channeled through non surge-type Trinity and Wykeham Glaciers alone. Dynamic discharge of the surge-type Mittie Glacier varied from 0.90 ± 0.09 Gt a−1 during its 2003 surge to 0.02 ± 0.02 Gt a−1 during quiescence in 2012, highlighting the importance of surge-type glaciers for interannual variability in regional mass loss. Queen Elizabeth Islands glaciers currently account for ~7.5% of reported dynamic discharge from Arctic ice masses outside Greenland.We thank NSERC, Canada Foundation for Innovation, Ontario Research Fund, ArcticNet, Ontario Graduate Scholarship, University of Ottawa and the NSERC Canada Graduate Scholarship for funding. RADARSAT-2 data were provided by MacDonald, Dettwiler and Associates under the RADARSAT-2 Government Data Allocation administrated by the Canadian Space Agency. Support to DB is provided through the Climate Change Geosciences Program, Earth Sciences Sector, Natural Resources Canada (ESS Contribution #20130293). We also acknowledge support from U.K NERC for grants R3/12469 and NE/K004999 to JAD.This is the accepted version of an article published in Geophysical Research Letters. An edited version of this paper was published by AGU. Copyright (2014) American Geophysical Union. The final version is available at http://onlinelibrary.wiley.com/doi/10.1002/2013GL058558/abstract;jsessionid=6A3AD907C4383DA5D4E20C4924D6EC18.f02t02

Non-orientable Boundary Superstring Field theory with Tachyon field

We use the BSFT method to study the unoriented open string field theory (type I). The partition function on the Mobius strip is calculated. We find that, at the one-loop level, the divergence coming from planar graph and unoriented graph cancel each other as expected.Comment: 17 pages, 2 figures, references adde

Selecting an Anti-Malarial Clinical Candidate from Two Potent Dihydroisoquinolones

BACKGROUND: The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable clinical candidate from late leads. The process used to select the clinical candidate SJ733 from two potent dihydroisoquinolone (DHIQ) late leads, SJ733 and SJ311, based on their physicochemical, pharmacokinetic (PK), and toxicity profiles is described. METHODS: The compounds were tested to define their physicochemical properties including kinetic and thermodynamic solubility, partition coefficient, permeability, ionization constant, and binding to plasma proteins. Metabolic stability was assessed in both microsomes and hepatocytes derived from mice, rats, dogs, and humans. Cytochrome P450 inhibition was assessed using recombinant human cytochrome enzymes. The pharmacokinetic profiles of single intravenous or oral doses were investigated in mice, rats, and dogs. RESULTS: Although both compounds displayed similar physicochemical properties, SJ733 was more permeable but metabolically less stable than SJ311 in vitro. Single dose PK studies of SJ733 in mice, rats, and dogs demonstrated appreciable oral bioavailability (60-100%), whereas SJ311 had lower oral bioavailability (mice 23%, rats 40%) and higher renal clearance (10-30 fold higher than SJ733 in rats and dogs), suggesting less favorable exposure in humans. SJ311 also displayed a narrower range of dose-proportional exposure, with plasma exposure flattening at doses above 200 mg/kg. CONCLUSION: SJ733 was chosen as the candidate based on a more favorable dose proportionality of exposure and stronger expectation of the ability to justify a strong therapeutic index to regulators

The inflationary bispectrum with curved field-space

We compute the covariant three-point function near horizon-crossing for a system of slowly-rolling scalar fields during an inflationary epoch, allowing for an arbitrary field-space metric. We show explicitly how to compute its subsequent evolution using a covariantized version of the separate universe or "delta-N" expansion, which must be augmented by terms measuring curvature of the field-space manifold, and give the nonlinear gauge transformation to the comoving curvature perturbation. Nonlinearities induced by the field-space curvature terms are a new and potentially significant source of non-Gaussianity. We show how inflationary models with non-minimal coupling to the spacetime Ricci scalar can be accommodated within this framework. This yields a simple toolkit allowing the bispectrum to be computed in models with non-negligible field-space curvature.Comment: 22 pages, plus appendix and reference