Analysis of Late Summer Heat Waves in the Northeast US

The climatological temperature maximum and heat wave frequency, defined as three or more consecutive days of maximum temperatures at or above 32 degrees Celsius, often peak around mid to late July in the Northeast United States. However, numerous notable heat waves have occurred in late August into early September, including 1953, 1973, and to a lesser extent 2015. An analysis of daily means of 500 hPa geopotential heights from the NCEP-NCAR Reanalysis dataset over a 67–year period (1948–2015), in addition to surface temperatures from numerous stations east of the Mississippi River, shows a secondary peak in mean temperatures, geopotential heights and heat wave frequency over the Northeast and Ohio Valley, and to a lesser extent in the Southeast, during the late summer. This peak is most evident in late August, both on the synoptic scale and on a localized scale in the selected stations. Composite 500–hPa geopotential height and surface analyses of the warmest late August into early September time frames exhibits an anomalous Western US trough and Eastern US ridge, and an anomalous surface high pressure center near the eastern US

Complete IRAC mapping of the CFHTLS-DEEP, MUSYC AND NMBS-II FIELDS

The IRAC mapping of the NMBS-II fields program is an imaging survey at 3.6 and 4.5$\mu$m with the Spitzer Infrared Array Camera (IRAC). The observations cover three Canada-France-Hawaii Telescope Legacy Survey Deep (CFHTLS-D) fields, including one also imaged by AEGIS, and two MUSYC fields. These are then combined with archival data from all previous programs into deep mosaics. The resulting imaging covers a combined area of about 3 $deg^2$, with at least $\sim$2 hr integration time for each field. In this work, we present our data reduction techniques and document the resulting coverage maps at 3.6 and 4.5$\mu$m. All of the images are W-registered to the reference image, which is either the z-band stack image of the 25\% best seeing images from the CFHTLS-D for CFHTLS-D1, CFHTLS-D3, and CFHTLS-D4, or the K-band images obtained at the Blanco 4-m telescope at CTIO for MUSYC1030 and MUSYC1255. We make all images and coverage maps described herein publicly available via the Spitzer Science Center.Comment: Accepted in PASP; released IRAC mosaics available upon publication of the pape

The regulation of MADS-box gene expression during ripening of banana and their regulatory interaction with ethylene

Six MaMADS-box genes have been cloned from the banana fruit cultivar Grand Nain. The similarity of these genes to tomato LeRIN is low and neither MaMADS2 nor MaMADS1 complement the tomato rin mutation. Nevertheless, the expression patterns, specifically in fruit and the induction during ripening and in response to ethylene and 1-MCP, suggest that some of these genes may participate in ripening. MaMADS1, 2, and 3, are highly expressed in fruit only, while the others are expressed in fruit as well as in other organs. Moreover, the suites of MaMADS-box genes and their temporal expression differ in peel and pulp during ripening. In the pulp, the increase in MaMADS2, 3, 4, and 5 expression preceded an increase in ethylene production, but coincides with the CO2 peak. However, MaMADS1 expression in pulp coincided with ethylene production, but a massive increase in its expression occurred late during ripening, together with a second wave in the expression of MaMADS2, 3, and 4. In the peel, on the other hand, an increase in expression of MaMADS1, 3, and to a lesser degree also of MaMADS4 and 2 coincided with an increase in ethylene production. Except MaMADS3, which was induced by ethylene in pulp and peel, only MaMADS4, and 5 in pulp and MaMADS1 in peel were induced by ethylene. 1-MCP applied at the onset of the increase in ethylene production, increased the levels of MaMADS4 and MaMADS1 in pulp, while it decreased MaMADS1, 3, 4, and 5 in peel, suggesting that MaMADS4 and MaMADS1 are negatively controlled by ethylene at the onset of ethylene production only in pulp. Only MaMADS2 is neither induced by ethylene nor by 1-MCP, and it is expressed mainly in pulp. Our results suggest that two independent ripening programs are employed in pulp and peel which involve the activation of mainly MaMADS2, 4, and 5 and later on also MaMADS1 in pulp, and mainly MaMADS1, and 3 in peel. Hence, our results are consistent with MaMADS2, a SEP3 homologue, acting in the pulp upstream of the increase in ethylene production similarly to LeMADS-RIN

Tropopause Polar Vortex Linkages to Arctic and Midlatitude Phenomena

Tropopause polar vortices (TPVs) are coherent, closed tropopause-based vortices that spend at least 60% of their lifetime poleward of 65° latitude. TPVs are identified by a local minima in potential temperature and height, and a local maxima in potential vorticity on the dynamic tropopause. TPVs are most common in the Arctic, where they are often associated with the intensification of Arctic cyclones (ACs), but on occasion exit the Arctic into the midlatitudes where they are often associated with cold air outbreaks (CAOs). This dissertation investigates TPV linkages to ACs, CAOs, and polar lows (PLs), focusing on systematic TPV-AC linkages and case studies of TPV intensity linkages to an AC case, a PL case, and a major CAO. Rapidly deepening ACs are commonly associated with an upstream TPV which becomes vertically aligned with the AC by the end of the rapid deepening episode. Summer cases are associated with closer proximity to the closest TPV and less lower-tropospheric baroclinic instability than winter cases, with summer cases often over the central Arctic Ocean and winter cases often in the North Atlantic into the Barents and Kara seas. Additionally, ACs whose rapid deepening episode coincides with cyclogenesis are less likely to be over the central Arctic Ocean and are farther from the closest TPV relative to ACs that develop at least 24 h prior to the onset of rapid deepening. Numerical simulations designed to modify the intensity of two TPVs associated with the August 2012 ``Great Arctic Cyclone" show that stronger TPVs are associated with a faster peak deepening rate and earlier peak intensity of the cyclone, but with the closer TPV to the AC exhibiting a greater impact on the intensification rate of the AC, and the farther TPV exhibiting a greater impact on the track of the AC. The increased intensification rate is primarily associated with stronger differential cyclonic vorticity advection downstream of the TPVs. Weakening the broader upper-tropospheric trough within which the closer TPV is embedded in results in a substantially weaker and more progressive AC. Applying the same TPV modification methodology to an intense PL case only results in very minimal impact on the intensity of the PL, and a 10-member initial condition uncertainty ensemble shows the track and intensity of the PL are more sensitive to the amplitude of a ridge upstream of the TPV than the intensity of the TPV. Finally, an investigation of the role of two merging TPVs in a historic CAO in the southern Great Plains in February 2021 shows both TPVs had a direct role in the evolution of the CAO, but that backward air parcel trajectories from the southern Great Plains were mostly associated with one TPV instead being distributed equally between both TPVs. The control simulation produces the coldest temperatures at the peak of the CAO in the southern Great Plains, as intensifying both TPVs results in an earlier merger and stronger cold pool but a slower and farther north resultant TPV, while weakening both TPVs results in a weaker cold pool. This result differs from past studies of TPV-CAO linkages where a single, fast-moving TPV exhibited a more direct linkage between TPV intensity and CAO magnitude

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

In response to tenacious stress signals, such as the unscheduled activation of oncogenes, cells can mobilize tumour suppressor networks to avert the hazard of malignant transformation. A large body of evidence indicates that oncogene-induced senescence (OIS) acts as such a break, withdrawing cells from the proliferative pool almost irreversibly, thus crafting a vital pathophysiological mechanism that protects against cancer. Despite the widespread contribution of OIS to the cessation of tumorigenic expansion in animal models and humans, we have only just begun to define the underlying mechanism and identify key players. Although deregulation of metabolism is intimately linked to the proliferative capacity of cells and senescent cells are thought to remain metabolically active, little has been investigated in detail about the role of cellular metabolism in OIS. Here we show, by metabolic profiling and functional perturbations, that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAFV600E, an oncogene commonly mutated in melanoma and other cancers. BRAFV600E-induced senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2). The resulting combined activation of PDH enhanced the use of pyruvate in the tricarboxylic acid cycle, causing increased respiration and redox stress. Abrogation of OIS, a rate-limiting step towards oncogenic transformation, coincided with reversion of these processes. Further supporting a crucial role of PDH in OIS, enforced normalization of either PDK1 or PDP2 expression levels inhibited PDH and abrogated OIS, thereby licensing BRAFV600E-driven melanoma development. Finally, depletion of PDK1 eradicated melanoma subpopulations resistant to targeted BRAF inhibition, and caused regression of established melanomas. These results reveal a mechanistic relationship between OIS and a key metabolic signalling axis, which may be exploited therapeutically

The THINICE field campaign: Interactions between Arctic cyclones, tropopause polar vortices, clouds and sea ice in summer

The THINICE field campaign, based from Svalbard in August 2022, provided unique observations of summertime Arctic cyclones, their coupling with cloud cover, and interactions with tropopause polar vortices and sea ice conditions. THINICE was motivated by the need to advance our understanding of these processes and to improve coupled models used to forecast weather and sea ice, as well as long-term projections of climate change in the Arctic. Two research aircraft were deployed with complementary instrumentation. The Safire ATR42 aircraft, equipped with the RALI (RAdar-LIdar) remote sensing instrumentation and in-situ cloud microphysics probes, flew in the mid-troposphere to observe the wind and multi-phase cloud structure of Arctic cyclones. The British Antarctic Survey MASIN aircraft flew at low levels measuring sea-ice properties, including surface brightness temperature, albedo and roughness, and the turbulent fluxes that mediate exchange of heat and momentum between the atmosphere and the surface. Long duration instrumented balloons, operated by WindBorne Systems, sampled meteorological conditions within both cyclones and tropospheric polar vortices across the Arctic. Several novel findings are highlighted. Intense, shallow low-level jets along warm fronts were observed within three Arctic cyclones using the Doppler radar and turbulence probes. A detailed depiction of the interweaving layers of ice crystals and supercooled liquid water in mixed-phase clouds is revealed through the synergistic combination of the Doppler radar, the lidar and in-situ microphysical probes. Measurements of near-surface turbulent fluxes combined with remote sensing measurements of sea ice properties are being used to characterize atmosphere-sea ice interactions in the marginal ice zone

The THINICE field campaign: Interactions between Arctic cyclones, tropopause polar vortices, clouds and sea ice in summer

International audienceThe THINICE field campaign, based from Svalbard in August 2022, provided unique observations of summertime Arctic cyclones, their coupling with cloud cover, and interactions with tropopause polar vortices and sea ice conditions. THINICE was motivated by the need to advance our understanding of these processes and to improve coupled models used to forecast weather and sea ice, as well as long-term projections of climate change in the Arctic. Two research aircraft were deployed with complementary instrumentation. The Safire ATR42 aircraft, equipped with the RALI (RAdar-LIdar) remote sensing instrumentation and in-situ cloud microphysics probes, flew in the mid-troposphere to observe the wind and multi-phase cloud structure of Arctic cyclones. The British Antarctic Survey MASIN aircraft flew at low levels measuring sea-ice properties, including surface brightness temperature, albedo and roughness, and the turbulent fluxes that mediate exchange of heat and momentum between the atmosphere and the surface. Long duration instrumented balloons, operated by WindBorne Systems, sampled meteorological conditions within both cyclones and tropospheric polar vortices across the Arctic. Several novel findings are highlighted. Intense, shallow low-level jets along warm fronts were observed within three Arctic cyclones using the Doppler radar and turbulence probes. A detailed depiction of the interweaving layers of ice crystals and supercooled liquid water in mixed-phase clouds is revealed through the synergistic combination of the Doppler radar, the lidar and in-situ microphysical probes. Measurements of near-surface turbulent fluxes combined with remote sensing measurements of sea ice properties are being used to characterize atmosphere-sea ice interactions in the marginal ice zone

The THINICE field campaign: Interactions between Arctic cyclones, tropopause polar vortices, clouds and sea ice in summer

The THINICE field campaign, based from Svalbard in August 2022, provided unique observations of summertime Arctic cyclones, their coupling with cloud cover, and interactions with tropopause polar vortices and sea ice conditions. THINICE was motivated by the need to advance our understanding of these processes and to improve coupled models used to forecast weather and sea ice, as well as long-term projections of climate change in the Arctic. Two research aircraft were deployed with complementary instrumentation. The Safire ATR42 aircraft, equipped with the RALI (RAdar-LIdar) remote sensing instrumentation and in-situ cloud microphysics probes, flew in the mid-troposphere to observe the wind and multi-phase cloud structure of Arctic cyclones. The British Antarctic Survey MASIN aircraft flew at low levels measuring sea-ice properties, including surface brightness temperature, albedo and roughness, and the turbulent fluxes that mediate exchange of heat and momentum between the atmosphere and the surface. Long duration instrumented balloons, operated by WindBorne Systems, sampled meteorological conditions within both cyclones and tropospheric polar vortices across the Arctic. Several novel findings are highlighted. Intense, shallow low-level jets along warm fronts were observed within three Arctic cyclones using the Doppler radar and turbulence probes. A detailed depiction of the interweaving layers of ice crystals and supercooled liquid water in mixed-phase clouds is revealed through the synergistic combination of the Doppler radar, the lidar and in-situ microphysical probes. Measurements of near-surface turbulent fluxes combined with remote sensing measurements of sea ice properties are being used to characterize atmosphere-sea ice interactions in the marginal ice zone