Landscape and geomorphic survey of Zhamanshin area, Northern Kazakhstan: Preliminary report on 1992 field trip data

The June 1992 geographical expedition to Zhamanshin crater area made a landscape and geomorphic survey of this impact structure. Observational points in the area of 300 sq km give new data on the geographical processes in the impact crater. The data obtained could be applied to search for unknown impact structures anywhere through the traces of such features in landscapes

Russia's contribution to regional geologic mapping of Venus

Geologic maps in Magellan C1-format were produced by six geologists and three cartographer in Russia during 1992. More sheets are in progress. The work is coordinated by Vernadsky Institute. The Magellan SRR images in form of C1-format photomaps were used as a base for geologic-geomorphic regional mapping of Venus at approximately 1:8,000,000 scale. This work took place in Russia at Vernadsky Institute and at the Department of Geology, Lomonosov Moscow University. The aim is to produce a preliminary geologic survey of Venus with the new high resolution images obtained by Magellan. It took place at the cartographic division, Laboratory of Comparative Planetology and Meteoritics, Vernadsky Institute, Russsia's Academy of Sciences

Geological-morphological description of the Sedna and Guinevre planitiae on Venus (photomap sheets B-11, B-20, B-21)

Presented are descriptions and maps of the region of Sedna and Guinevra Planitiae--representatives of the largest geological providense on Venus comprised of volcanic rock. Units of different age are isolated and their relations are given, as well as interpretations of proposed mechanisms of formation

Relief and geology of the north polar region of the planet Venus

Description of topographic features is given for the North polar region of the planet Venus. Principal geomorphic types of terrain are characterized as well as their geologic relations. Relative ages of geologic units in Venus North polar region are discussed

miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).

Objective- Vascular calcification (VC) is age dependent and a risk factor for cardiovascular and all-cause mortality. VC involves the senescence-induced transdifferentiation of vascular smooth muscle cells (SMCs) toward an osteochondrogenic lineage resulting in arterial wall mineralization. miR-34a increases with age in aortas and induces vascular SMC senescence through the modulation of its target SIRT1 (sirtuin 1). In this study, we aimed to investigate whether miR-34a regulates VC. Approach and Results- We found that miR-34a and Runx2 (Runt-related transcription factor 2) expression correlates in young and old mice. Mir34a <sup>+/+</sup> and Mir34a <sup>-/-</sup> mice were treated with vitamin D, and calcium quantification revealed that Mir34a deficiency reduces soft tissue and aorta medial calcification and the upregulation of the VC Sox9 (SRY [sex-determining region Y]-box 9) and Runx2 and the senescence p16 and p21 markers. In this model, miR-34a upregulation was transient and preceded aorta mineralization. Mir34a <sup>-/-</sup> SMCs were less prone to undergo senescence and under osteogenic conditions deposited less calcium compared with Mir34a <sup>+/+</sup> cells. Furthermore, unlike in Mir34a <sup>+/+</sup> SMC, the known VC inhibitors SIRT1 and Axl (AXL receptor tyrosine kinase) were only partially downregulated in calcifying Mir34a <sup>-/-</sup> SMC. Strikingly, constitutive miR-34a overexpression to senescence-like levels in human aortic SMCs increased calcium deposition and enhanced Axl and SIRT1 decrease during calcification. Notably, we also showed that miR-34a directly decreased Axl expression in human aortic SMC, and restoration of its levels partially rescued miR-34a-dependent growth arrest. Conclusions- miR-34a promotes VC via vascular SMC mineralization by inhibiting cell proliferation and inducing senescence through direct Axl and SIRT1 downregulation, respectively. This miRNA could be a good therapeutic target for the treatment of VC

Remote Estimation of Net Ecosystem CO2 Exchange in Crops: Principles, Technique Calibration and Validation

Accurate and synoptic estimation of spatially distributed CO2 fluxes is of great importance for regional and global studies of carbon balance. A technique solely based on remotely sensed data was developed and tested for estimating net ecosystem CO2 exchange (NEE) in maize and soybean. The model is based on the reflectance in two spectral channels: the near-infrared and either the green or red-edge around 700 nm. The technique provides accurate estimations of mid-day NEE in both crops under either rainfed or irrigated conditions, explaining more than 85% of NEE variation in maize and more than 81% in soybean, and shows great potential for remotely tracking crop NEE

Zoonotic hepatitis E: animal reservoirs and emerging risks

Hepatitis E virus (HEV) is responsible for enterically-transmitted acute hepatitis in humans with two distinct epidemiological patterns. In endemic regions, large waterborne epidemics with thousands of people affected have been observed, and, in contrast, in non-endemic regions, sporadic cases have been described. Although contaminated water has been well documented as the source of infection in endemic regions, the modes of transmission in non-endemic regions are much less known. HEV is a single-strand, positive-sense RNA virus which is classified in the Hepeviridae family with at least four known main genotypes (1–4) of mammalian HEV and one avian HEV. HEV is unique among the known hepatitis viruses, in which it has an animal reservoir. In contrast to humans, swine and other mammalian animal species infected by HEV generally remain asymptomatic, whereas chickens infected by avian HEV may develop a disease known as Hepatitis-Splenomegaly syndrome. HEV genotypes 1 and 2 are found exclusively in humans while genotypes 3 and 4 are found both in humans and other mammals. Several lines of evidence indicate that, in some cases involving HEV genotypes 3 and 4, animal to human transmissions occur. Furthermore, individuals with direct contact with animals are at higher risk of HEV infection. Cross-species infections with HEV genotypes 3 and 4 have been demonstrated experimentally. However, not all sources of human infections have been identified thus far and in many cases, the origin of HEV infection in humans remains unknown