Theoretical and practical aspects of economic security of the Russian forest industry

Purpose: The forest sector in Russia is of great ecological, economic and social importance not only locally, but also globally. Digitalization of society, of course, entails a change in financial, economic and legal postulates. The article indicates the interconnection between the economic security of the Russian Federation and security of forest industry. Design / Methodology / Approach: The article reveals the prospects of economic security of forest industry on the basis of the analysis of statistical data on crimes committed and the historical background of Russian forest industry. Results: On the basis of the conducted research the author gives recommendations on choosing the strategy for development of forestry in Russia, represents statistical data on crimes committed in forest industry. Practical implications: The applied value of the study is expressed in highlighting the ways of Russian forest industry development as a vital element of Russian economy and economic security in the context of modern development of society. Originality/Value: The originality of the author's approach is in summarizing the findings on the basis of regional, historical and legal analysis taking into account the transformation of economic systems and the modernization of the world community.peer-reviewe

Bimodule structure of the mixed tensor product over Uqsℓ(2∣1)U_{q} s\ell(2|1) and quantum walled Brauer algebra

We study a mixed tensor product $\mathbf{3}^{\otimes m} \otimes \mathbf{\overline{3}}^{\otimes n}$ of the three-dimensional fundamental representations of the Hopf algebra $U_{q} s\ell(2|1)$, whenever $q$ is not a root of unity. Formulas for the decomposition of tensor products of any simple and projective $U_{q} s\ell(2|1)$-module with the generating modules $\mathbf{3}$ and $\mathbf{\overline{3}}$ are obtained. The centralizer of $U_{q} s\ell(2|1)$ on the chain is calculated. It is shown to be the quotient $\mathscr{X}_{m,n}$ of the quantum walled Brauer algebra. The structure of projective modules over $\mathscr{X}_{m,n}$ is written down explicitly. It is known that the walled Brauer algebras form an infinite tower. We have calculated the corresponding restriction functors on simple and projective modules over $\mathscr{X}_{m,n}$. This result forms a crucial step in decomposition of the mixed tensor product as a bimodule over $\mathscr{X}_{m,n}\boxtimes U_{q} s\ell(2|1)$. We give an explicit bimodule structure for all $m,n$.Comment: 43 pages, 5 figure

Problems of Threats to Russia’s Economic Security in Cooperation with the Countries of the Eurasian Economic Union in the Context of Administrative and Legal Regulation

The paper examines topical the problems of minimizing threats to Russia’s economic security when interacting with the countries of the Eurasian Economic Union in the context of administrative and legal regulation, problems arising in the organization of this work and the direction of their improvement. The objective of the study is to comprehensively study, analyze and summarize the theoretical provisions and results of practical activities in the sphere of minimizing threats to Russia’s economic security when interacting with the countries of the Eurasian Economic Union in the context of administrative and legal regulation. Methodology: Approved scientific methods for the comprehensive study of phenomena and processes in their interdependence and, above all, the didactic method of cognition. In the process of collection and processing of empirical material, the author used a comprehensive, systemic, axiological and synergetic approaches that ensure a comprehensive study of the problems of minimizing threats to Russia’s economic security when interacting with the countries of the Eurasian Economic Union in the context of administrative and legal regulation. Results: it is necessary to confess that government activity on providing of economic security and defense of national interests of country in area of economy must come true on permanent basis.     Keywords: minimization of threats of economic security to Russia; Eurasian Economic Union; administrative legal regulation; system of theoretical knowledge and practical recommendations of minimization of threats of economic security to Russia at cooperating with the countries of the Eurasian economic union; assistance to development of small and middle enterprise due to the decline of financial and administrative expenses; diagnostics and monitoring of economic strength security

ELIMINATION OF FALSE RESULTS OF MEDICINES MICROBIOLOGICAL TESTING

The validity of medicines microbial quality testing relies on the adequacy of the test procedure employed. The aim of the study was to analyse factors triggering false results during microbial quality testing of non-sterile  medicinal products, as well as to find ways of their elimination.  Materials and methods: the study was focused on non-sterile  medicinal products tested for microbial quality: N-methylglucamine, L-Malic  acid, Xeroform, Fingolimod hydrochloride, Succinic  acid, Streptocide,  Aripiprazole, Doxazosin, Clopidogrel,  Moxonidine, Tilorone,  Mycophenolic acid, Folic acid, Gabapentin, Dutasteride, Imatinib,  Temozolomide. The study involved the use of the following test strains: Bacillus subtilis, Bacillus cereus, Candida albicans, Escherichia coli, Aspergillus brasiliensis, as well as of reagents and growth media. The methods  used were determination of antimicrobial  activity under conditions of microbial quality testing, and modified in-depth  testing of microbial quality of medicinal products according to the requirements of the State Pharmacopoeia of the Russian Federation, 13th edition. Results: the analysis of literature sources helped reveal the main factors causing false results of microbiological  testing and determine  ways of their elimination.  The article sets forth the results of experimental comparison of two ways of sample preparation  for solid formulations: the standard one described in the State Pharmacopoeia of the Russian Federation, 13th edition, and the one involving the use of a laboratory shaker. The article provides experimental data on specific aspects of elimination of antimicrobial activity against B. subtilis and B. cereus and the use of specific inactivators for particular medicinal products. Conclusions: a set of measures aimed at prevention of false-positive and false-negative testing results should include: sterility control of the growth media and reagents used, monitoring  of facilities; control of growth promotion  properties and selectivity of the growth media; selection of adequate incubation  conditions  and inoculation procedure with due regard to the dosage form; justification of the amount of sample, diluents and dilution factor used; consideration  of the antimicrobial activity of a medicinal product

The impact of social isolation during a pandemic on the psychological health and social condition of dependent people among the able-bodied population of the Voronezh region

The purpose of the study is to assess the impact of social isolation on the mental state of people with signs of alcohol, gambling and Internet addiction.Цель исследования – провести оценку влияния социальной изоляции на психическое состояние людей, имеющих признаки алкогольной, игровой и интернет - зависимости

Nonequilibrium Magnetization Dynamics of Gadolinium Studied by Magnetic Linear Dichroismin Time-Resolved 4f Core-Level Photoemission

The magnetic linear dichroism of the gadolinium 4f core level is studied in a time-resolved photoemission experiment employing laser pump- and synchrotron-radiation probe pulses. Upon optical excitation of the 5d6s valence electrons with femtosecond laser pulses, the magnetic order in the 4f spin system is reduced. Remarkably, the linear dichroism remains at 80% of the equilibrium contrast while the lattice temperature reaches the Curie temperature due to electron-phonon scattering. Contrasting itinerant ferromagnets, this shows that equilibration between the lattice and spin subsystems takes in Gd about 80 ps and is established in parallel with heat diffusion

Intraspecific Differentiation of <i>Francisella tularensis</i> Strains Using Multilocus Real-Time Polymerase Chain Reaction

The aim of the study was to develop a method for intraspecific differentiation of the tularemia microbe: subspecies tularensis (subpopulations AI and AII), holarctica (biovars japonica, EryS/R), mediasiatica, and novicida using multilocus real-time PCR. Materials and methods. We used 48 strains of F. tularensis of various subspecies, biovars, and subpopulations. Intraspecific appurtenance of the strains was carried out on the basis of the analysis of the RD-1 region variability applying PCR, the sdhA gene by Sanger fragment sequencing and by the disk diffusion method using disks with erythromycin. The selection of primers and probes was performed using the software available at www.genscript.com and GeneRunner 6.5.52. Sequence homology was assessed using the BLAST algorithm and the GenBank NCBI database. Results and discussion. New data on the structure and occurrence of the differentiation regions RD-8, RD-12, RD-28 of FTT1122c gene and its homologous sequences in strains of tularemia microbe of various subspecies have been obtained. Novel RDhm 346 bp in size, characteristic of strains of the subsp. mediasiatica, holarctica, which is deleted in subsp. tularensis and absent in subsp. novicida has been detected. Based on the detection of the FTT1670, FTT1122с, FTT1067, FTW_2084 loci, a multilocus real-time PCR has been developed – “F. tularensis 4c”, providing for identification of all subspecies of the tularemia microbe, separately for the biovar japonica of the Holarctic subspecies and subpopulations AI, AII of the subspecies tularensis. The PCR specificity was confirmed in the study of strains of tularemia microbe from the fund of the “State Collection of Pathogenic Bacteria” at the premises of the Russian Reserarch Anti-Plague Institute “Microbe”. The results obtained expand the concept of intraspecific genetic heterogeneity of tularemia microbe and possibilities of identifying the causative agent of tularemia using molecular-genetic methods. They are important for understanding the processes of adaptation of the pathogen to circulation in the host organism and environmental objects, the course of evolution and formation of new species of Francisella

DIAGNOSTIC VALUE OF SEROLOGICAL MARKERS OF RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is a classic autoimmune disease associated with the production of wide range of autoantibodies, and their detection has diagnostic and prognostic implication. The objective of this study was to estimate the diagnostic value of antibodies against modified citrullinated vimentin (AMCV) and nuclear antigen RA33 of the IgA rheumatoid factor (RF) versus the value of routinely used profile of autoantibodies in diagnostic work-up of RA. Material and methods. 253 patients with RA prehistory of varying duration were included into the study group. The control group was comprised of 92 patients, including patients with seronegative spondyloarthropathies and diffuse connective tissue diseases, as well as sex and age matched healthy controls. Serum levels of IgM and IgA RF, antibodies against cyclic citrullinated peptide (ACCP), ACMV, anti-keratin antibodies (AKA), antibodies against RA33 antigen (ARA33) and antinuclear factor (ANF) were measured in all patients and controls. Results and discussion. Diagnostic sensitivity of AMCV equaled 78%, ACCP — 77%, IgM RF — 71%, IgA RF — 43%, AKA — 43%, ARA33 — 31% and ANF — 31%. All anti-citrullinic antibodies (AKA, ACCP, ACMV) were significantly more commonly associated with IgM RF. Among RF and ACCP seronegative patients ACMV were found in 24% cases with 20 IU/Ml detection threshold, and in 21% — with 30 IU/Ml, allowing to increase diagnostic specificity of the test up to 91% with the increment of diagnostic threshold. Incidence of ARA33 was not significantly different among the RF and ACCP positive or negative subgroups, thus making ARA33 an independent RA marker. Specificity of this marker was 87,9%, thus making it inferior to RF and ACCP by a composite of diagnostic characteristics. Conclusions. Integrated measurement of ACMV and ARA33 is a rational approach at the second stage of serologic testing work-up in suspected cases of RA onset, when initial RF and ACCP tests were negative