16 research outputs found
Fatal bilateral pneumonitis after locoregional thoracic chemoradiation in a transplanted patient under immunosuppressive therapy
Background: After thoracic radiotherapy a pneumonitis may occur, mostly confined to the irradiated volume of the lung. In general, it resolves spontaneously without long-term effects. Case Report: A 68-year-old man was diagnosed with a stage IIIA adenocarcinoma of the lung and was treated with sequential chemoradiation. He had a heart and kidney transplant for which an immunosuppressant was taken. During the fourth week of radiotherapy, he developed a bilateral interstitial pneumonia. Despite antibiotics and steroids, the patient died twelve days after the onset of complaints due to respiratory failure. Autopsy showed in all pulmonary lobes extensive diffuse alveolar damage, probably leading to respiratory insufficiency and death. Literature and Conclusion: Bilateral pneumonitis after radiotherapy is thought to be an immunologically-mediated response, which usually resolves without long-term effects. Since in radiation pneumonitis an increase in T-cells is described, the suppression of these cells by an immunosuppressant might have exaggerated the pulmonary toxicity
Seed micromorphology of Acanthophyllum C.A. Mey. (Caryophyllaceae) Genus in Turkey
In this study, seeds of 5 species of Acanthophyllum in Turkey were
examined with stereomicroscope and scanning electron microscope (SEM) to
evaluate the systematic significance of seed microstructure. The seeds
of Acanthophyllum were characterised by oblong or obovate shape. Seeds
dorsal and ventral side are generally convex. The largest seeds are
found in A. acerosum (2.45 mm in length and 1.16 mm in width). The
smallest seeds are found in A. verticillatum (1.61 mm in length and 0.84
mm in width). Seeds surface of Acanthophyllum species are fine
tuberculate arranged with elongate or polygonal cells like jigsaw
puzzle. The shape of suture is sinuous, undulate or dentate. The colour
of seed is reddish-brown or yellowish-brown. The radicle is on the one
side of each seed and just out beyond the hilar notch. Colour of seeds,
seed length and width, hilum length and width, suture shape, testa cell
shape and the number of suture points per plate are important characters
in differentiating Acanthophyllum species. By this study, similarities
and differences between the species of Acanthophyllum genus are revealed
and contributed to taxonomic studies
Tratamento cirúrgico de fraturas em martelo por bloqueio da extensão com fio de Kirschner
OBJETIVO: Avaliar a eficácia do tratamento da fratura em martelo, pelo método de Ishiguro de bloqueio de extensão com fio de Kirschner. MÉTODOS: Trinta e oito pacientes foram tratados prospectivamente. O acompanhamento médio foi 18 meses e todos os pacientes foram avaliados radiológica e clinicamente, de acordo com os critérios de Crawford. RESULTADOS: A união da fratura foi obtida em todos os pacientes. Os resultados alcançados foram satisfatórios em 34 casos e não satisfatórios em quatro casos. CONCLUSÃO: Consideramos que a técnica de bloqueio de extensão é segura e eficaz e pode ser usada em todas as fraturas em martelo. Nível de Evidência IV, Série de Caso
Tongue myokymia presenting twelve years after radiation therapy
Objective: This case is a patient with tongue myokymia following radiation therapy 12 years earlier, documented using video and EMG. Case report: A 68-year-old woman with a history of nasopharyngeal carcinoma presented with subacute onset of difficulty in speaking and involuntary movements of her tongue approximately 12 years after radiation therapy to head and neck. Electromyography displayed myokymic discharges. There was no evidence of recurrent malignancy. Significance: Delayed effects of radiation therapy might be seen decades later. Myokymic discharges may reveal radiation-induced neuropathy. Keywords: Tongue myokymia, Radiation therapy, Long-term effect
Synthesis and characterization of complexes of a novel proton transfer salt and their inhibition studies on carbonic anhydrase isoenzymes
A novel proton transfer compound (HClABT)(+)(HDPC.H2DPC)(-) (1) and its
Fe(III), Co(II), Ni(II) and two different Cu(II) complexes (2-6) have
been prepared and characterized by spectroscopic techniques.
Additionally, single crystal X-ray diffraction techniques were applied
to all complexes. All compounds, including acetazolamide (AAZ) as the
control compound, were also evaluated for their in vitro inhibition
effects on human hCA I and hCA II for their hydratase and esterase
activities. Although there is no inhibition for hydratase activities,
all compounds have inhibited the esterase activities of hCA I and II.
The comparison of the inhibition studies of 1-6 to parent compounds,
ClABT and H2DPC, indicates that 1-6 have superior inhibitory effects.
The inhibition effects of 2-6 are also compared to the inhibitory
properties of the simple metal complexes of ClABT and H2DPC, revealing
an improved transfection profile. Data have been analysed by using a
one-way analysis of variance for multiple comparisons
A novel proton transfer salt of 2-amino-6-sulfamoylbenzothiazole and its metal complexes: the evaluation of their inhibition effects on human cytosolic carbonic anhydrases
A novel proton transfer compound (SMHABT) (+)(HDPC)(-) (1) obtained from
2-amino-6-sulfamoylbenzothiazole (SMABT) and 2,6-pyridinedicarboxylic
acid (H2DPC) and its Fe(III), Co(II), Ni(II) complexes (2-4), and Fe(II)
complex of SMABT (5) have been prepared and characterized by
spectroscopic techniques. Additionally, single crystal X-ray diffraction
techniques were applied to complexes (2-4). All complexes (2-4) have
distorted octahedral conformations and the structure of 5 might be
proposed as octahedral according to spectral and analytical results. All
compounds, including acetazolamide (AAZ) as the control compound, were
also evaluated for their in vitro inhibition effects on human hCA I and
hCA II for their hydratase and esterase activities. The synthesized
compounds have remarkable inhibitory activities on hCA I and hCA II.
Especially, the inhibition potentials of the salt and the metal
complexes (1-5) are comparable with AAZ. Inhibition data have been
analyzed by using a one-way analysis of variance for multiple
comparisons (p < .0001)
Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005-2006: A Hospital-Based Study
Rotavirus is the main cause of gastroenteritis and dehydration requiring hospitalization among infants and children. Despite the high diarrhea-related mortality rate, there are limited studies describing the prevalence of rotavirus in Turkey. The disease burden of rotavirus gastroenteritis in Turkey was assessed by active, prospective surveillance conducted in accordance with a modified World Health Organization generic protocol from 1 June 2005 through 1 June 2006. A total of 411 children aged <5 years who were hospitalized for gastroenteritis in 4 centers were enrolled. Rotavirus was identified in 53% of samples from the 338 children tested; the range for individual centers was 32.4%-67.4%. Overall, 83.8% of rotavirus-positive children were aged <2 years. Rotavirus gastroenteritis occurred year-round but peaked in the winter. G1P[8] was the most widely prevalent strain (76% of strains), followed by G2P[4] (12.8%). G9P[8] was reported in samples from 3.9% of children. These data support the need for a rotavirus vaccine in Turkey
Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005-2006: A Hospital-Based Study
WOS: 000270655100026PubMed ID: 19817603Rotavirus is the main cause of gastroenteritis and dehydration requiring hospitalization among infants and children. Despite the high diarrhea-related mortality rate, there are limited studies describing the prevalence of rotavirus in Turkey. The disease burden of rotavirus gastroenteritis in Turkey was assessed by active, prospective surveillance conducted in accordance with a modified World Health Organization generic protocol from 1 June 2005 through 1 June 2006. A total of 411 children aged <5 years who were hospitalized for gastroenteritis in 4 centers were enrolled. Rotavirus was identified in 53% of samples from the 338 children tested; the range for individual centers was 32.4%-67.4%. Overall, 83.8% of rotavirus-positive children were aged <2 years. Rotavirus gastroenteritis occurred year-round but peaked in the winter. G1P[8] was the most widely prevalent strain (76% of strains), followed by G2P[4] (12.8%). G9P[8] was reported in samples from 3.9% of children. These data support the need for a rotavirus vaccine in Turkey.GlaxoSmithKline Biologicals, Rixensart, BelgiumGlaxoSmithKline [104377]; GAVI AllianceFinancial support: research grant from GlaxoSmithKline Biologicals, Rixensart, Belgium (eTrack 104377).; Supplement sponsorship: This article was published as part of a supplement entitled "Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines," which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance