Bilateral perineal hernia with bladder retroflexion in a 13-year-old intact Jack-Russel Dog: Case report

A 13-year-old male Jack-Russel was presented to the Usmanu Danfodiyo University Veterinary Teaching Hospital, Sokoto because of a swollen perineum. Physical and laboratory examinations revealed normal parameters, however a bilateral protrusion was noticed at the perineum suggestive of a bilateral perineal hernia. Contrast radiography revealed a hernia sac with intestinal segments on the left, urinary bladder and prostate on the right. Standard obturator muscle transpositional herniorhaphy was successfully performed.Keywords: Bilateral Perineal Hernia, Bladder Retroflexion, Cystic Kidney, Canine

Design of Radiation Pattern-Reconfigurable 60-GHz Antenna for 5G Applications

noReconfigurable beam steering using circular disc microstrip patch antenna with a ring slotis proposed. The overall dimension of the antenna is 5.4×5.4 mm2 printed on a 0.504 mm thick, Rogers RT5870 substrate with relative permittivity 2.3 and loss tangent 0.0012. The designed antenna operates at the expected 5G frequency band 60 GHz with a central coaxial probe feed. TwoNMOS switches are configured to generate three different beam patterns. Activating each switch individually results in a near 70 degree shift in the main beam direction, whereas the frequency characteristics are unchanged. The power gains are between 3.9 dB and 4.8dB for the three states of switches configurations. Simulated results in terms of return loss, peak gains and radiation pattern are presented and show a reasonable agreement at the expected 60 GHz bandfor 5G applications.The published journal webpage is no longer available

Effects of menotrophin and chorulon on superovulation in Red Sokoto does

The aim of this study was to compare the efficiency of menotrophin, chorulon and their combinations in superovulation in Red Sokoto does. Fifteen healthy does weighed  between 14 and 25 kg were divided into 3 groups of 5 (n=5) each. All does in the 3 groups were synchronized with CIDR for 14 days. Superovulation was performed as follows: Group 1 were treated with 37.5 IU menotrophin for three days, group 2 were treated with 500IU chorulon for 1 day and group 3 were treated with 18.75 iμ  menotrophin for 3 days and 250IU chorulon for one day. The mean SEM superovulatory response in group 1, 2 and 3 was (2.6 0.92, 3.2 0.58 and 9.4 0.68) respectively. The superovulatory response showed no significant differences between group 1 and 2  however, there were statistically significance differences (p<0.01) between groups 1 and 3 and between 2 and 3. These result showed that the combination of Menotrophin and Chorulon effectively produces multiple ovulations as a result the use this  combination is advocated.Keywords: Chorulon, CIDR, Doe, Menotrophin, Sokoto, Superovulatio

Comparison of equatorial plasma bubble zonal drifts and neutral winds velocity over Southeast Asia

The purpose of the presented study is to investigate the zonal drifts of Equatorial Plasma Bubbles (EPB) which applied two different ground-based instruments. Malaysia Real-Time Kinematics GNSS Network (MyRTKnet), consists more than 78 GPS receivers was used to observe EPB along 96° East to 120° East longitudes. Subsequently, zonal drift of EPBs derived from GPS-ROTI is compared with neutral winds velocity from Fabry-Perot interferometer (FPI). On 10 April 2013, we founded the maximum drift is about 194.4 m/s at 1430 UT to 1500 UT whereas the minimum drift is 111.1 m/s at 1330 UT to 1400 UT. The results illustrate that temporal variations of EPB zonal drift velocities are consistent with the neutral winds

Functional Mechanisms Underlying Pleiotropic Risk Alleles at the 19p13.1 Breast–Ovarian Cancer Susceptibility Locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P = 9.2 X 10-20), ER-negative BC (P = 1.1 X 10-13), BRCA1 -associated BC (P = 7.7 X 10-16) and triple negative BC (P-diff = 2 X 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P = 2 X 10-3) and ABHD8 (P \u3c 2 X 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8 , and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3\u27-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84-0.87; P=1.7 × 10(-43)) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology