4. National Support for Behavioral Science

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67094/2/10.1177_000276425800100504.pd

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data

There is a need to develop and validate biomarkers for treatment response and survival in tubo-ovarian high-grade serous carcinoma (HGSC). The chemotherapy response score (CRS) stratifies patients into complete/near-complete (CRS3), partial (CRS2), and no/minimal (CRS1) response after neoadjuvant chemotherapy (NACT). Our aim was to review current evidence to determine whether the CRS is prognostic in women with tubo-ovarian HGSC treated with NACT.This article is freely available via Open Access. Click on the Publisher URL to access the full-text via the publisher's site

ADR in the Administrative Law: A Perspective from the United Kingdom

Administrative ADR encompasses a number of grievance mechanisms that provide an alternative to court litigation. However, due to space constraints, the chapter focuses on three types of ADR, namely, “internal appeal,” “mediation,” and the “public Ombudsman.” A central claim of this work is that there exists a fine balance between PDR and the constitutional values that are intrinsic to a system of administrative justice. There is sufficient evidence, for instance, to suggest that public Ombudsmen, despite their shortcomings and need for reform, have the greatest potential to strike this fine balance between PDR and fundamental constitutional values. That said, there are many more issues that should be looked at here, some of which are fundamental, such as the place of ADR in common law and the issue of ADR specifically in public law, while one may still want to be cautious about the divide between public law and private law in the context of the common law. Finally, there is also an issue of balance to be sought between the use of ADR and the quality of administrative justice

Women who work: the limits of the Neoliberal feminist paradigm

This article examines Ivanka Trump's Women Who Work, arguing that it represents the newest permutation of the neoliberal feminist subject. After providing an overview of the recent emergence of neoliberal feminism, I explain why the book should be considered part of the wider cultural landscape in which this variant of feminism has increasingly become commonsensical. I then turn to demonstrate how Women Who Work construes the ideal female subject not only as generic human capital but also incites her to invest in herself constantly, where activities ranging from professional workshops through hobbies to friendships are understood as practices that appreciate the value of the self. The conversion of women into generic rather than gendered human capital remains, however, incomplete, since the ideal of a happy work–family balance continues to serve as a push back to the wholesale erasure of traditional notions of sexual difference. Finally, I highlight that neoliberal feminism is erasing other long‐standing divisions and political differences. Not only does the private–public divide collapse, but so, too, does the distinction between one's private self and one's public enterprise as the self itself becomes an enterprise. This dual process of collapse and reconfiguration shapes the newest neoliberal feminist subject, the main protagonist of Trump's Women Who Work