Effect of edge conditions on buckling of stiffened and framed shells

"October 20, 1967.""A series of stiffened shells made of plastic were tested to verify the theoretical equations for the effect of edge conditions on the buckling of stiffened and framed shells. The theory was developed by calculating the deflections during loading and prior to buckling, and by using a large deflection stability approach. The agreement between the test results and the theory was good. Tests also confirmed that the edges could be stiffened and relatively high buckling loads could be obtained by increasing the meridional curvature near the edge of the shell."--Summary

Space Research Spinoff to Structural Engineering

Research for space applications has resulted in a considerable amount of valuable spinoff information to practicing structural engineers outside the space related fields. The spinoff has not been limited to any one field, but cuts across the lines of many industries serving the public, For example, specific applications can be traced to the agricultural industry, commercial power generation, school and building construction, and hydrospace applications. Examples are given where funds from NASA and other space oriented organizations have been combined with funds from private organizations such as the American Iron aid Steel Institute, the American Institute of Steel Construction and from private corporations to produce results that are applicable to both space efforts and commercially oriented efforts

Application of Turn- Key Construction to Industrialized Urban Housing in Missouri

Housing can be the answer to prayers for the declining technically-oriented aerospace industry. According to Look magazine the Soviet Union is outproducing the U.S. two to one in new housing units for its people and nearly every country in Western Europe now outproduces us. It would be most unfortunate if we were first on the moon, first in defense, but last in housing. Industrialization and new financing methods for housing offer great opportunities to provide success for most groups which are often at odds. A 50 billion dollar a year business will produce profits for stockholders, hundreds of thousands of new jobs for labor including minority groups, an opportunity for young people to rebuild America, and a new, diversified area for investors

NACA Technical Notes

Report presenting a theoretical solution for the buckling of Alclad plates on the basis of plasticity theory. Both the differential equation of equilibrium of the buckled plate and energy expression are provided. Results regarding the buckling of long simply supported plates under longitudinal compression and under shear and for a plate column are provided

NACA Technical Notes

"Three-dimensional interaction surfaces are presented for the computation of elastic buckling stresses for an infinitely long flat plate subjected to combinations of bending, shear, and transverse compression in its plane - a loading approximating that occurring in a shear web. Surfaces are presented for two sets of edge conditions: both edges simply supported and lower edge simply supported, upper edge clamped. Present results are in good agreement with data for one-load and two-load limiting cases previously published" (p. 1)

Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: Results from two phase I studies

Purpose: PTK787/ZK 222584 (PTK/ZK), an orally active inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, inhibits VEGF-mediated angiogenesis. The pharmacodynamic effects of PTK/ZK were evaluated by assessing changes in contrast-enhancement parameters of metastatic liver lesions using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced colorectal cancer treated in two ongoing, dose-escalating phase I studies. Patients and Methods: Twenty-six patients had DCE-MRI performed at baseline, day 2, and at the end of each 28-day cycle. Doses of oral PTK/ZK ranged from 50 to 2000 mg once daily. Tumor permeability and vascularity were assessed by calculating the bidirectional transfer constant (Ki). The percentage of baseline Ki (% of baseline Ki) at each time point was compared with pharmacokinetic and clinical end points. Results: A significant negative correlation exists between the % of baseline Ki and increase in PTK/ZK oral dose and plasma levels (P = .01 for oral dose; P = .0001 for area under the plasma concentration curve at day 2). Patients with a best response of stable disease had a significantly greater reduction in Ki at both day 2 and at the end of cycle 1 compared with progressors (mean difference in % of baseline Ki, 47%, P = .004%; and 51%, P = .006; respectively). The difference in % of baseline Ki remained statistically significant after adjusting for baseline WHO performance status. Conclusion: These findings should help to define a biologically active dose of PTK/ZK. These results suggest that DCE-MRI may be a useful biomarker for defining the pharmacological response and dose of angiogenesis inhibitiors, such as PTK/ZK, for further clinical development. © 2003 by American Society of Clinical Oncology