05391 Abstracts Collection -- Algebraic and Numerical Algorithms and Computer-assisted Proofs

From 25.09.05 to 30.09.05, the Dagstuhl Seminar 05391 ``Algebraic and Numerical Algorithms and Computer-assisted Proofs\u27\u27 was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. Links to extended abstracts or full papers are provided, if available

05391 Executive Summary -- Numerical and Algebraic Algorithms and Computer-assisted Proofs

The common goal of self-validating methods and computer algebra methods is to solve mathematical problems with complete rigor and with the aid of computers. The seminar focused on several aspects of such methods for computer-assisted proofs

DNase1L2 Degrades Nuclear DNA during Corneocyte Formation

The removal of keratinocyte (KC) nuclear DNA by deoxyribonucleases (DNases) is an important step in the formation of normal stratum corneum (SC). However, the molecular identity of the DNA-degrading enzymes has so far remained elusive. Here we show that the endonuclease DNase1-like 2 (DNase1L2) is preferentially expressed in the epidermis and that its expression correlates with terminal differentiation of KC in vitro and in vivo. In biopsies of normal skin, DNase1L2 mRNA was regularly found in suprabasal KC and DNase1L2 protein was highly abundant in the stratum granulosum. In contrast to normal skin, DNase1L2 expression was downregulated in parakeratotic epidermis such as in psoriatic lesions. When DNase1L2 gene expression was knocked down by small interfering RNA in a human skin equivalent model, nuclei were maintained through all layers of the SC. Taken together, our data demonstrate that DNase1L2 plays an essential role in DNA degradation during terminal differentiation of epidermal KC

Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

Motor Neurone Disease Association (Malaspina/Apr13/817–791). Wellcome Trust support to a parallel study (Pathfinder Award, grant number 103208)

Gallus, Caius Vibius Trebonianus

Michael J. Gallus, Caius Vibius Trebonianus. In: Buchberger M, ed. Lexikon für Theologie und Kirche. Bd. 4: Franca bis Hermenegild. 3. völlig neu bearb. Aufl. Freiburg: Herder; 1995: 282