The Scottish economy [August 1984]

Throughout much of the last two years the official view has been that the Scottish recession was less severe than that experienced in the United Kingdom as a whole. Indeed, the Secretary of State has proclaimed to a variety of audiences, including the House of Commons, that Scotland was, and still is , leading the country out of recession. This diagnosis has not met with universal approval, as it appears to be founded primarily on the growth of the Scottish electronics sector and on the smaller proportionate rise in unemployment which has occurred in Scotland than in Britain as a whole. This latter fact is not particularly surprising as the pre-recession level of unemployment in Scotland was markedly above that of the rest of Britain

Outlook and appraisal [August 1984]

Growth in the British economy came almost to a halt during the first half of this year. As a result , even a speedy resolution of the coal dispute would be unlikely to push the GDP growth rate this year above 2.5 Though much of July's interest rate increase has already been reversed, it is likely to prove more difficult to reverse the effects on the retail price index and thus attain the goal of H.5% inflation at the end of the year. The uncompetitive nature of the housing finance market makes a speedy and full unwinding of the recent rise in mortgage rates unlikely

The influence of weather-type and long-range transport on airborne particle concentrations in Edinburgh, UK

This study investigated the influence of regional-scale synoptic weather type and geographical source regions of air masses on two-particle concentration metrics (Black Smoke (BS) and PM10) in the city of Edinburgh, UK, between 1981 and 1996. Twenty-seven classifications of Jenkinson Daily Weather Types (JWT) were subdivided into 9 directional categories and 3 vorticity categories, and the influence of JWT category on BS and PM10 determined. Four-day air mass back-trajectories for 1 July 1995–30 June 1996 were computed and grouped into 8 categories depending on the geographical route followed. Significantly elevated concentrations of BS (median values 2, 5 and 4 μg m−3 greater than median for 1981–1996) and PM10 (median values 3, 5.5 and 8 μg m−3 greater than median for 1992–1996) were observed for anticyclonic, southerly and south-easterly weather types, respectively. These differences were not identified at conventional levels of significance for BS in 1995– 1996. This may reflect a shift in more recent times to lower concentrations of predominantly locally emitted BS less affected by regional scale meteorology. Conversely, significant inter-trajectory category differences were observed for PM10 during 1995–1996, with highest concentrations associated with Eastern European trajectories and south-easterly weather type categories (11.4 and 10.7 μg m−3 greater than annual means, respectively). The variation in particle concentration across weather-type was a significant proportion of total median particle concentration, and of a magnitude associated with adverse health outcomes. Thus current PM10 concentrations (and associated health outcomes) in Edinburgh are likely to be significantly influenced by regional-scale meteorology independent of local air quality management areas. Furthermore, changes in long-term trends in distributions of synoptic weather types indicate that future climate change may influence exposure to PM10 and the PM10:BS ratio in Edinburgh. Further definition of the relationships between long-range transport and particle concentration will improve classification of human exposure in epidemiological studies

Review of the quarter's economic trends [May 1983]

The one thing this recovery does not lack is confidence. Surveys of business opinion in all the major economies reveal a greater level of optimism amongst the business community than at any time since 1979. But confidence alone is not adequate for a sustained recovery though it certainly helps. As this brief analysis shows, two constraints stand in the way of a worldwide upturn: real interest rates remain high and the response of governments to any acceleration of inflation remains unknown. The downward rigidity of nominal interest rates bears witness to the financial markets' belief that present low levels of inflation are not sustainable, yet if governments react to the expected mild acceleration of inflation in the latter half of this year with the policies of the recent past no significant recovery is likely. Further analysis of UK and world economic data are provided

Streetsport: Supporting and facilitating the development of enhanced graduate attributes.

Streetsport is a programme that aims to exercise social innovation by reducing instances of youth crime and anti-social behaviour; whilst promoting health and wellbeing through sport, physical activity and creative endeavour. As a vehicle for delivery the initiative facilitates work based educational experiences that are embedded within disadvantaged communities; supporting the development of enhanced graduate attributes by way of collaborative teaching and learning support. Adopting a collaborative partnership model, the programme brings together multiple courses, students and stakeholders to work within communities resulting in activities that react and respond to local needs, interests and demand

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity

Peer reviewedPublisher PD

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

TRY plant trait database – enhanced coverage and open access

Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments

Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests