115 research outputs found
Distinct CD4:CD8 T cell ratio in adult and neonatal mice correlates with either Th1 or Th2 CD4 immunity, respectively, specific for transplantation antigens
- Author
- Publication venue
- 'University of Saskatchewan Library'
- Publication date
- Field of study
Previous studies employing the generation of MHC-incompatible embryonic chicken chimaeras by injecting MHC-incompatible stem cells resulted in an unexpected finding. Chimaeras made late in gestation developed as adults a severe autoimmune syndrome resembling the human syndrome of Systemic Lupus Erythematosus.
Work in our laboratory aims to understand the role of CD8 T cells in immunity and/or autoimmunity. We have tested a three-cell model of CD4 T cell activation and differentiation during the development of the immune response specific for MHC transplantation antigens in one way mixed lymphocyte reactions. Our model proposes that whether Th1 or Th2 immunity is generated depends on both the ratio of CD4:CD8 T cells specific for antigen at the initiation of the immune response and on the ability of antigens to coordinately induce both CD4 and CD8 T cells.
Previous studies employing parent into F1 models of graft-versus-host disease in mice have shown that the injection of parental cells results in two distinct outcomes. Parental cells which do not have a sufficient number of CD8 T cells present produce an autoimmune syndrome characteristic of systemic lupus erythematosus and a chronic graft-versus-host disease mediated by a Th2 response. Conversely, the presence of an adequate number of CD8 T cells results in a Th1 immune response and acute graft-versus-host disease resulting in the death of the F1 host.
Our findings indicate that the ratio of the number of CD4 T cells to the number of CD8 T cells present in the spleen is crucial in whether naive CD4 T cells differentiate into Th1 or Th2 cells. We refer to this ratio as the CD4:CD8 T cell ratio or CD4:CD8 ratio. Thus, the differentiation of naive CD4+ T cells towards a differentiated Th1 phenotype is critically dependent on the concomitant induction of CD8 T cells by the same antigen, driven by a low CD4:CD8 ratio. In contrast, inefficient induction of CD8 T cells during the initial priming of lymphocytes greatly facilitates the differentiation of CD4 T cells towards the Th2-type lineage, and occurs when the CD4:CD8 ratio is high.
Given our findings on the significance of the ratio of CD4:CD8 T cells in the decision making process of CD4 differentiation stimulated by antigen, we hypothesized that different CD4: CD8 ratios at different stages of development might contribute to the immune response generated at these stages.
We tested this hypothesis in mice by comparing the CD4:CD8 ratio in adults and neonates and the Th1/Th2 responses generated in vitro. This CD4:CD8 T cell ratio is significantly higher in neonates than adults resulting in predominant Th1 responses by adult spleen cells and Th1/Th2 responses by neonatal spleen cells as demonstrated by the ELISPOT assay.
We have compared the CD4:CD8 T cell ratio of a large number of adult and neonatal spleens in several mouse strains and have studied it systematically in BALB/c and C57BL/6 mice by flow-cytometry. We have consistently found a 3-5 fold higher CD4:CD8 T cell ratio in neonates as compared to adults in the strains tested. Furthermore, we found that neonatal spleen cells generate a predominant Th2 response whereas adult spleen cells generate CD4 and CD8 Th1 immunity when activated under the same conditions.
We have further studied the role of CD8 T cells in CD4 T cell differentiation by reconstructing the adult CD4:CD8 T cell ratio in neonatal spleen cells with age-matched, isolated CD8 T cells. We found that in these âCD4:CD8 ratio-reconstructed culturesâ, the Th2/IL-4 immunity is suppressed with concomitant generation of Th1/IFN-Îł immunity upon activation by allo-antigen. Additionally, we have characterized the phenotype of the T cell mediating Th1/IFNÎł immunity in the âCD4:CD8 ratio reconstructed culturesâ and we found that while CD8 T cells produce exclusively IFN-Îł, CD4 T cells now produce IFN-Îł rather than IL-4.
We suggest that physiologically distinct CD4:CD8 ratios at different stages of life should be considered in designing protocols of neonatal vaccination against pathogens that are contained by Th1-type immunity upon infection as adults. Moreover, as elaborated in the discussion, our studies might be pertinent in understanding by which mechanism autoimmunity arises in some cases
Characterization of a Novel STAT 2 Knock Out Hamster Model of Crimean Congo Hemorrhagic Fever Virus Pathogenesis
- Author
- Publication venue
- Hosted by Utah State University Libraries
- Publication date
- 23/07/2020
- Field of study
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing a febrile illness in humans, which can progress to hemorrhagic manifestations, multi-organ failure, and death. Current mouse models of CCHFV infection reliably succumb to virus challenge but vary in their ability to reflect signs of disease similar to humans. In this study, we established a signal transducer and activator of transcription 2 (STAT2) knockout hamster model to expand the repertoire of animal models of CCHFV pathogenesis that can be used for therapeutic development. These hamsters demonstrated a systemic and lethal disease in response to infection. Hallmarks of human disease were observed including petechial rash, blood coagulation dysfunction, and various biochemistry and blood cell count abnormalities. Furthermore, we also demonstrated the utility of this model for anti-CCHFV therapeutic evaluation. The STAT2 knock-out hamster model of CCHFV infection may provide some further insights into clinical disease, viral pathogenesis, and pave the way for testing of potential drug and vaccine candidates
LSST: from Science Drivers to Reference Design and Anticipated Data Products
- Author
- Abel Bob
- Acosta Emily
- Allsman Robyn
- Alonso David
- AlSayyad Yusra
- Anderson Scott F.
- Andrew John
- Angel James Roger P.
- Angeli George Z.
- Ansari Reza
- Antilogus Pierre
- Arancibia Freddy Muñoz
- Araujo Constanza
- Armstrong Robert
- Arndt Kirk T.
- Astier Pierre
- Aubourg Ăric
- Auza Nicole
- Axelrod Tim S.
- Bard Deborah J.
- Barr Jeff D.
- Barrau Aurelien
- Bartlett James G.
- Bauer Amanda E.
- Bauman Brian J.
- Baumont Sylvain
- Bechtol Ellen
- Bechtol Keith
- Becker Andrew C.
- Becla Jacek
- Beldica Cristina
- Bellavia Steve
- Bianco Federica B.
- Biswas Rahul
- Blanc Guillaume
- Blandford Roger D.
- Blazek Jonathan
- Bloom Josh S.
- Bogart Joanne
- Bond Tim W.
- Booth Michael T.
- Borgland Anders W.
- Borne Kirk
- Bosch James F.
- Boutigny Dominique
- Brackett Craig A.
- Bradshaw Andrew
- Brandt William Nielsen
- Brown Michael E.
- Bullock James S.
- Burchat Patricia
- Burke David L.
- Cagnoli Gianpietro
- Calabrese Daniel
- Callahan Shawn
- Callen Alice L.
- Carlin Jeffrey L.
- Carlson Erin L.
- Chandrasekharan Srinivasan
- Charles-Emerson Glenaver
- Chesley Steve
- Cheu Elliott C.
- Chiang Hsin-Fang
- Chiang James
- Chirino Carol
- Chow Derek
- Ciardi David R.
- Claver Charles F.
- Cockrum Joseph J.
- Cohen-Tanugi Johann
- Coles Rebecca
- Connolly Andrew J.
- Cook Kem H.
- Cooray Asantha
- Covey Kevin R.
- Cribbs Chris
- Cui Wei
- Cutri Roc
- Daly Philip N.
- Daniel Scott F.
- Daruich Felipe
- Daubard Guillaume
- Daues Greg
- Dawson William
- De Val-Borro Miguel
- Delgado Francisco
- Dellapenna Alfred
- Digel Seth W.
- Doherty Peter
- Dubois Richard
- Dubois-Felsmann Gregory P.
- Durech Josef
- Economou Frossie
- Eifler Tim
- Emmons Benjamin L.
- Eracleous Michael
- Fausti Neto Angelo
- Ferguson Henry
- Figueroa Enrique
- Fisher-Levine Merlin
- Focke Warren
- Foss Michael D.
- Frank James
- Freemon Michael D.
- Gangler Emmanuel
- Gawiser Eric
- Geary John C.
- Gee Perry
- Geha Marla
- Gessner Charles J.B.
- Gibson Robert R.
- Gilmore D.Kirk
- Glanzman Thomas
- Glick William
- Goldina Tatiana
- Goldstein Daniel A.
- Goodenow Iain
- Graham Melissa L.
- Gressler William J.
- Gris Philippe
- Guy Leanne P.
- Guyonnet Augustin
- Haller Gunther
- Harris Ron
- Hascall Patrick A.
- Haupt Justine
- Hernandez Fabio
- Herrmann Sven
- Hileman Edward
- Hoblitt Joshua
- Hodgson John A.
- Hogan Craig
- Howard James D.
- Huang Dajun
- Huffer Michael E.
- Ingraham Patrick
- Innes Walter R.
- IveziÄ Ćœeljko
- Jacoby Suzanne H.
- Jain Bhuvnesh
- Jammes Fabrice
- Jee James
- Jenness Tim
- Jernigan Garrett
- JevremoviÄ Darko
- Johns Kenneth
- Johnson Anthony S.
- Johnson Margaret W.G.
- Jones R.Lynne
- Juramy-Gilles Claire
- JuriÄ Mario
- Kahn Steven M.
- Kalirai Jason S.
- Kallivayalil Nitya J.
- Kalmbach Bryce
- Kantor Jeffrey P.
- Karst Pierre
- Kasliwal Mansi M.
- Kelly Heather
- Kessler Richard
- Kinnison Veronica
- Kirkby David
- Knox Lloyd
- Kotov Ivan V.
- Krabbendam Victor L.
- Krughoff K.Simon
- Ku John
- KubĂĄnek Petr
- Kuczewski John
- Kulkarni Shri
- Kurita Nadine R.
- Lage Craig S.
- Lambert Ron
- Lange Travis
- Langton J.Brian
- Le Guillou Laurent
- Levine Deborah
- Liang Ming
- Lim Kian-Tat
- Lintott Chris J.
- Long Kevin E.
- Lopez Margaux
- Lotz Paul J.
- Lupton Robert H.
- Lust Nate B.
- MacArthur Lauren A.
- Mahabal Ashish
- Mandelbaum Rachel
- Markiewicz Thomas W.
- Marsh Darren S.
- Marshall Philip J.
- Marshall Stuart
- May Morgan
- McKercher Robert
- McQueen Michelle
- Meyers Joshua
- Migliore Myriam
- Miller Michelle
- Mills David J.
- Miraval Connor
- Moeyens Joachim
- Monet David G.
- Moniez Marc
- Monkewitz Serge
- Montgomery Christopher
- Moolekamp Fred E.
- Morrison Christopher B.
- Mueller Fritz
- Muller Gary P.
- Neill Douglas R.
- Newbry Scott P.
- Nief Jean-Yves
- Nomerotski Andrei
- Nordby Martin
- O'Connor Paul
- O'Mullane William
- Oliver John
- Olivier Scot S.
- Olsen Knut
- Ortiz Sandra
- Osier Shawn
- Owen Russell E.
- Pain Reynald
- Palecek Paul E.
- Parejko John K.
- Parsons James B.
- Pease Nathan M.
- Peterson J.Matt
- Peterson John R.
- Petravick Donald L.
- Petrick M.E. Libby
- Petry Cathy E.
- Peyster Robert de
- Pierfederici Francesco
- Pietrowicz Stephen
- Pike Rob
- Pinto Philip A.
- Plante Raymond
- Plate Stephen
- Plutchak Joel P.
- Price Paul A.
- Prouza Michael
- Radeka Veljko
- Rajagopal Jayadev
- Rasmussen Andrew P.
- Regnault Nicolas
- Reil Kevin A.
- Reiss David J.
- Reuter Michael A.
- Ridgway Stephen T.
- Riot Vincent J.
- Ritz Steve
- Robinson Sean
- Roby William
- Roodman Aaron
- Rosing Wayne
- Roucelle Cecille
- Rumore Matthew R.
- Russo Stefano
- Saha Abhijit
- Sassolas Benoit
- Schalk Terry L.
- Schellart Pim
- Schindler Rafe H.
- Schmidt Samuel
- Schneider Donald P.
- Schneider Michael D.
- Schoening William
- Schumacher German
- Schwamb Megan E.
- Sebag Jacques
- Selvy Brian
- Sembroski Glenn H.
- Seppala Lynn G.
- Serio Andrew
- Serrano Eduardo
- Shaw Richard A.
- Shipsey Ian
- Sick Jonathan
- Silvestri Nicole
- Slater Colin T.
- Smith J.Allyn
- Smith R.Chris
- Sobhani Shahram
- Soldahl Christine
- Storrie-Lombardi Lisa
- Stover Edward
- Strauss Michael A.
- Street Rachel A.
- Stubbs Christopher W.
- Sullivan Ian S.
- Sweeney Donald
- Swinbank John D.
- Szalay Alexander
- Takacs Peter
- Tether Stephen A.
- Thaler Jon J.
- Thayer John Gregg
- Thomas Sandrine
- Thornton Adam J.
- Thukral Vaikunth
- Tice Jeffrey
- Trilling David E.
- Turri Max
- Tyson J.Anthony
- Van Berg Richard
- Vanden Berk Daniel
- Vetter Kurt
- Virieux Francoise
- Vucina Tomislav
- Wahl William
- Walkowicz Lucianne
- Walsh Brian
- Walter Christopher W.
- Wang Daniel L.
- Wang Shin-Yawn
- Warner Michael
- Wiecha Oliver
- Willman Beth
- Winters Scott E.
- Wittman David
- Wolff Sidney C.
- Wood-Vasey W.Michael
- Wu Xiuqin
- Xin Bo
- Yoachim Peter
- Zhan Hu
- Publication venue
- 'American Astronomical Society'
- Publication date
- 23/05/2018
- Field of study
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg2 field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5Ï
point-source depth in a single visit in r will be âŒ24.5 (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg2 with
ÎŽ<+34.5â, and will be imaged multiple times in six bands, ugrizy,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg2 region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to râŒ27.5. The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Interface entre história da matemåtica e ensino: uma atividade desenvolvida com base num documento do século XVI
- Author
- ALFONSO-GOLDFARB A. M
- ALFONSO-GOLDFARB A. M
- ALFONSO-GOLDFARB A. M.
- ALFONSO-GOLDFARB A. M.
- ALFONSO-GOLDFARB A. M.
- AMORIM M. P.
- AMORIM M. P.
- AXWORTHY A
- BALDI B
- BARTOLI C
- BASTOS T. R
- BELHOSTE B
- BELTRAN M. H. R.
- BELTRAN M. H. R.
- BENNETT J
- BENNETT J
- BENNETT J
- BESSE J.-M
- BIAGIOLI M
- BOYER C. B
- BROMBERG C.
- BRYCE J. H
- BUTTERFIELD H
- BUTTERFIELD H
- CAJORI F
- CAMEROTA F
- CANTOR M. B
- CIOCCI A
- CORMACK L. B
- D'AMBROSIO U
- D'AMBROSIO U
- D'AMBROSIO U
- DAVĂDOV V
- DEBUS A. G
- DIAS A. L. M
- DIAS M. S.
- DIAS M. S.
- DIAS M. S.
- DIAS M. S.
- DIAS M. S.
- DUARTE N
- EVES H
- FARIA J. T. de
- FAUVEL J.
- FOUCAULT M
- FOUCAULT M
- FOWLER D. H
- FURINGHETTI F
- GIARDINETTO J. R. B
- GRATTAN-GUINNESS I
- HEILBRON J. L
- HEILBRONNER J. C
- JAHNKE H. N
- KOPNIN P. V
- KOPNIN P. V
- LEONTIEV A
- MAAR A
- MENDES I. A
- MENDES I. A
- MIGUEL A
- MIGUEL A.
- MIGUEL A.
- MIORIM M. A.
- MOISĂS R. P.
- MONTUCLA J.-Ă
- MOURA A. R. L. de
- MOURA M. O
- NOBRE S
- POPPER N
- ROSSI P
- ROUX S
- RUBINSTEIN S. L
- SAITO F.
- SAITO F.
- SAITO F.
- SAITO F.
- SAITO F.
- SAITO F.
- SILVA J. J. da
- SIQUEIRA R. M. de
- SMITH D. E
- SOUSA M. C.
- TAYLOR E. G. R
- TURNER G. L. E
- VAN HELDEN A
- WARNER D. J
- WARNER D. J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
- Field of study
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- ArĂšne M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae S.
- Bae Y.
- Bagnasco Stefano
- Bai Y.
- Baier J. G.
- Baird J.
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Bartlett J.
- Barton Mark Andrew
- Bartos I.
- Basak S.
- Bassiri Riccardo
- Basti A.
- Bawaj Mateusz
- Bayley Joseph
- Bazzan M.
- Beatrice Cummings Rebecca
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Belahcene I.
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- BenYaala M.
- Bera S.
- Berbel Marina
- Bergamin F.
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bhandare R.
- Bhandari A. V.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bianchi A.
- Bilenko I. A.
- Bilicki Maciej
- Billingsley GariLynn
- Bini S.
- Birnholtz Ofek
- Biscans S.
- Bischi M.
- Bisht A.
- Biswas Bhaskar
- Bitossi M.
- Blackburn Kent
- Blair C. D.
- Blair D. G.
- Blair R. M.
- Bobba F.
- Bode Nina
- Bogaert G.
- Boldrini M.
- Bolingbroke Georgia
- Bonavena L. D.
- Bondarescu Ruxandra
- Bondu F.
- Bonilla Carrasquel Edgard
- Bonnand Romain
- Booker P.
- Bork R.
- Boschi Valerio
- Bose N.
- Bose S.
- Bossilkov V.
- Boudart Vincent
- Bouffanais Y.
- Bozzi A.
- Boër M.
- Bradaschia C.
- Brady Patrick R.
- Bramley A.
- Branch A.
- BRANCHESI Marica
- Brau James E.
- Breschi Matteo
- Briant Tristan
- Briggs J. H.
- Brillet A.
- Brinkmann M.
- Brockill P.
- Brooks Aidan
- Brooks J.
- Brown D. D.
- Brunett S.
- Bruno G.
- Bruntz Robert
- Bryant J.
- Bucci F.
- Buchanan J.
- Bulik T.
- Bulten H. J.
- Buonanno Alessandra
- Burtnyk K.
- Buscicchio Riccardo
- Buskulic D.
- Buy Christelle
- Byer R. L.
- BĂ©csy Bence
- C. Utina Andrei
- Cabourn Davies Gareth
- Cabras Giuseppe
- Cabrita Ricardo
- Cadonati Laura
- Cagnoli Gianpietro
- Cahillane C.
- CalderĂłn Bustillo J.
- Callaghan J. D.
- Callister T. A.
- Calloni E.
- Camp J. B.
- Canepa M.
- Caneva Santoro Giada
- Cannavacciuolo M.
- Cannon Kipp C.
- Cao H.
- Capistran L. A.
- Capocasa Eleonora
- Capote E.
- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carpinelli M.
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
- Caudill S.
- Cavaglia Marco
- Cavalier Fabien
- Cavalieri Roberto
- Cella Giancarlo
- CerdĂĄ-DurĂĄn P.
- Cesarini Elisabetta
- Chaibi W.
- Chakalis W.
- Chalathadka Subrahmanya Shreevathsa
- Champion Elizabeth
- Chan C.
- Chan C. -H.
- Chan K.
- Chan M.
- Chandra K.
- Chang I. P.
- Chang W.
- Chanial Pierre
- Chao S.
- Chapman-Bird Christian
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen ChianShu
- Chen Dan
- Chen Hsin-Yu
- Chen Junxin
- Chen K.
- Chen X.
- Chen Y.
- Chen Y. -B.
- Chen Y. -R.
- Cheng H.
- Chessa Piero
- Cheung H. Y.
- Chia H. Y.
- Chiadini Francesco
- Chiang C-Y.
- Chiarini G.
- Chierici R.
- Chincarini Andrea
- Chiofalo M. L.
- Chiummo Antonino
- Choudhary R. K.
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- Christensen Nelson
- Chu Q.
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- Chun Lung Chan Juno
- Chung K. W.
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- Ciecielag P.
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- Ciolfi Riccardo
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- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Cleva F.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Cohen David
- Colleoni Marta
- Collette C. G.
- Colombo Alberto
- Colpi M.
- Compton C. M.
- Concetta Tringali Maria
- Conti Livia
- Cooper S. J.
- Corban P.
- Corbitt Thomas
- Cordero-CarriĂłn Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Coschizza A. C.
- Cotesta R.
- Cottingham R.
- Coughlin Michael
- Coulon J. -P.
- Countryman S. T.
- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creighton Jolien
- Creighton T. D.
- Criswell Alexander
- Croquette Michaël
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming A.
- Cuoco E.
- CuryĆo M.
- D'Angelo Beatrice
- D'Antonio S.
- D'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Dana A.
- Danilishin Stefan
- Danzmann K.
- Darsow-Fromm Christian
- Dasgupta A.
- Datrier L. E. H.
- Datta Sayak
- Datta Sayantani
- Dattilo V.
- Dave I.
- Davier M.
- Davis Derek
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Laurentis M.
- De Lillo Federico
- De Lillo N.
- de Lluc Planas Maria
- De Matteis F.
- De Pietri Roberto
- De Rosa Rosario
- De Rossi C.
- De Simone R.
- de Souza Melo S. Assis
- DeBra D.
- Deenadayalan M.
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- Zhao Yuhang
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- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- çè°š
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
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- Aronson Scott
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- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williamson Andrew R.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
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- Chalathadka Subrahmanya Shreevathsa
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- de rossi camilla
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- Elizabeth Ramirez Guevara Karla
- Emma Mattia
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- error error
- error error
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- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Poetics of the Archive
- Publication venue
- Newcastle Centre for the Literary Arts/AHRC
- Publication date
- Field of study
Cupric and nickel ion interactions with proteins as studied by circular dichroism
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1969
- Field of study
Recommended from our members
Advanced Design of a Binding Plate to Reduce Anterior Cruciate Ligament Injury during Alpine Skiing
- Publication venue
- Worcester Polytechnic Institute - Gordon Library
- Publication date
- 25/04/2013
- Field of study
The objective of this project is to reduce the incidence of Anterior Crucial Ligament (ACL) injury in skiing by designing, prototyping, and testing a plate between the ski and binding to filter out injurious loads that would otherwise be transmitted to the skier. Ski technology in the past 5 decades has adapted to protect the skierâs foot, ankle, and tibia, the knee and ACL are still susceptible to injury. There are two types of ACL injuries; Boot-Induced Anterior Drawer (BIAD) and phantom foot. Axiomatic Design was used to design a ski binding plate to minimize BIAD ACL injuries. After the design was chosen, calculations, material selection, computer aided design drawings, and finite element analysis were conducted. This project holds importance in both a societal and economic context
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