Passive fetal monitoring sensor

An ambulatory, passive sensor for use in a fetal monitoring system is discussed. The invention is comprised of a piezoelectric polymer film, combined with a metallic mounting plate fastened to a belt, and electrically connected to a signal processing unit by means of a shielded cable. The purpose of the sensor is to receive pressure pulses emitted by a fetus inside an expectant mother. Additionally, the monitor will filter out pressure pulses arising from other sources, such as the maternal heart

Positive state mindfulness: A multidimensional model of mindfulness in relation to positive experience

The present research tested Langer’s theory of mindfulness in the context of positive experiences: positive state mindfulness. In Study 1 (N1 = 586, N2 = 415) confirmatory factor analyses indicated that a three-factor model (Focused Attention, Novelty Appreciation, Open-Ended Expectations) fit the data well and explained responses better than a one-factor model. In support of construct validity, Study 2 (N3 = 239, N4 = 126) suggested that each dimension had a different pattern of associations with unidimensional trait measures of mindfulness, savoring beliefs, trait absorption, uncertainty tolerance, need for structure, and need for cognition. Study 3 (N5 = 46) revealed that each dimension correlated uniquely with the positive affect, self-esteem, interpersonal connectedness, and the overall rehearsal frequency associated with positive autobiographical events. In support of criterion validity in Study 4, in Experiment 1 (N6 = 46) a boredom task decreased Novelty Appreciation, and in Experiment 2 (N7 = 92) a problem-solving task increased Focused Attention. Our data suggest that positive mindfulness is more than the absence of mindlessness and that it includes three distinct dimensions. We discuss the utility of positive mindfulness in both research and practice

Method for Fabricating Piezoelectric Polymer Acoustic Sensors

A method for forming a sensor includes providing a first and a second film and bonding an internal connection tab there between. The internal connection tab is positioned between the inner surfaces of the first and second film. Then, a conductive adhesive is applied to either the tab or to the inner film surfaces such that the inner surfaces of the film and the tab are electrically connected. Finally, the films are pressed together to bond the film together with the internal connection tab in between

Vacuum holding fixture and method for fabricating piezoelectric polymer acoustic sensors

An apparatus and method for bonding a first film to a second film to form a sensor. The first and second films are piezoelectric films. A base section has a mating surface for holding the first film. A top section has a mating surface for holding the second film, the top section and base section being mateable together to form a cavity between the top section mating surface and the base section mating surface with the first film and the second film pressed together inside the cavity to bond the first film to the second film. An internal connection port forming mechanism forms an internal connection port between the first film and the second film when the base section and top section are mated together with the first film and the second film pressed together inside the cavity. Alternately, an internal connection tab forming mechanism can be used to form a sensor having an internal connection tab between the first and second film, instead of having an internal connection port

Method for simultaneously making a plurality of acoustic signal sensor elements

A fetal heart monitoring system preferably comprising a backing plate having a generally concave front surface and a generally convex back surface, and at least one sensor element attached to the concave front surface for acquiring acoustic fetal heart signals produced by a fetus within a body. The sensor element has a shape that conforms to the generally concave back surface of the backing plate. In one embodiment, the at least one sensor element comprises an inner sensor, and a plurality of outer sensors surrounding the inner sensor. The fetal heart monitoring system can further comprise a web belt, and a web belt guide movably attached to the web belt. The web belt guide being is to the convex back surface of the backing plate

Population Response of Three Quail Species to Habitat Restoration in South Texas

Maintaining and increasing usable space is paramount for maintaining and increasing wild quail. Aside from weather and other factors that can temporarily reduce densities, range-wide, no factor has as much influence on quail populations as the amount of habitat present across the landscape. In the field of quail management, ‘‘bad news’’ is the norm, as many articles begin by explaining how a select species has declined. Here we provide good news and use 4 empirical examples of population increases for 3 quail species following creation of usable space and restoration of patch connectivity. From 2008–2014, a suite of independent projects aimed at increasing usable space for quail was initiated across South Texas. These projects included 3 focused on northern bobwhites (Colinus virginianus), 1 focused on scaled quail (Callipepla squamata), and 1 landowner-executed project focused on Montezuma quail (Cyrtonyx montezumae). Through the correction of attributes limiting habitat, bobwhite numbers increased 22–378% across 2 studies. On one particular study site, native grassland restoration resulted in the colonization of bobwhites from adjacent areas to 1 bobwhite/1.2 ha from nearly 0. For scaled quail in South Texas, reducing buffelgrass standing crop via grazing from about 2,240 kg/ha to 1,008 kg/ha resulted in the recolonization of a previously unoccupied habitat patch to a density of 1 scaled quail/6 ha. Finally, clearing monotypic stands of the invasive native plant, ash juniper (Juniperus ashei) in the Edwards Plateau of Texas, resulted in the reestablishment of native grasses and forbs and thus recolonization by Montezuma quail from nearby areas. Although habitat restoration and management can be a painstaking and lengthy process, addressing limiting factors to quail occupancy is the only known way to increase wild quail populations. We hope that highlighting these particular studies will provide inspiration to those interested in restoring and increasing quail across the US

Identification of a Functional Non-coding Variant in the GABA

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the GABRA2 locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. Gabra2 expression varies as a function of genotype and is modulated by sequence variants in several brain structures and populations, including F2 crosses originating from C57BL/6J (B6J) and the BXD recombinant inbred family derived from B6J and DBA/2J. Here we demonstrate a global reduction of GABRA2 brain protein and mRNA in the B6J strain relative to other inbred strains, and identify and validate the causal mutation in B6J. The mutation is a single base pair deletion located in an intron adjacent to a splice acceptor site that only occurs in the B6J reference genome. The deletion became fixed in B6J between 1976 and 1991 and is now pervasive in many engineered lines, BXD strains generated after 1991, the Collaborative Cross, and the majority of consomic lines. Repair of the deletion using CRISPR-Cas9-mediated gene editing on a B6J genetic background completely restored brain levels of GABRA2 protein and mRNA. Comparison of transcript expression in hippocampus, cortex, and striatum between B6J and repaired genotypes revealed alterations in GABA-A receptor subunit expression, especially in striatum. These results suggest that naturally occurring variation in GABRA2 levels between B6J and other substrains or inbred strains may also explain strain differences in anxiety-like or alcohol and drug response traits related to striatal function. Characterization of the B6J private mutation in the Gabra2 gene is of critical importance to molecular genetic studies in neurobiological research because this strain is widely used to generate genetically engineered mice and murine genetic populations, and is the most widely utilized strain for evaluation of anxiety-like, depression-like, pain, epilepsy, and drug response traits that may be partly modulated by GABRA2 function

International comparison of cosmetic outcomes of breast conserving surgery and radiation therapy for women with ductal carcinoma in situ of the breast

Purpose: To assess the cosmetic impact of breast conserving surgery (BCS), whole breast irradiation (WBI) fractionation and tumour bed boost (TBB) use in a phase III trial for women with ductal carcinoma in situ (DCIS) of the breast. Materials and methods: Baseline and 3-year cosmesis were assessed using the European Organization for Research and Treatment of Cancer (EORTC) Cosmetic Rating System and digital images in a randomised trial of non-low risk DCIS treated with postoperative WBI +/- TBB. Baseline cosmesis was assessed for four geographic clusters of treating centres. Cosmetic failure was a global score of fair or poor. Cosmetic deterioration was a score change from excellent or good at baseline to fair or poor at three years. Odds ratios for cosmetic deterioration by WBI dose-fractionation and TBB use were calculated for both scoring systems. Results: 1608 women were enrolled from 11 countries between 2007 and 2014. 85-90% had excellent or good baseline cosmesis independent of geography or assessment method. TBB (16 Gy in 8 fractions) was associated with a >2-fold risk of cosmetic deterioration (p

Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic

During the peak phase of the COVID-19 pandemic, alterations of standard operating procedures were necessary for health systems to protect patients and healthcare workers and ensure access to vital hospital resources. As the peak phase passes, re-activation plans are required to safely manage increasing clinical volumes. In the context of cardiovascular magnetic resonance (CMR), re-activation objectives include continued performance of urgent CMR studies and resumption of CMR in patients with semi-urgent and elective indications in an environment that is safe for both patients and health care workers

A primary care, multi-disciplinary disease management program for opioid-treated patients with chronic non-cancer pain and a high burden of psychiatric comorbidity

BACKGROUND: Chronic non-cancer pain is a common problem that is often accompanied by psychiatric comorbidity and disability. The effectiveness of a multi-disciplinary pain management program was tested in a 3 month before and after trial. METHODS: Providers in an academic general medicine clinic referred patients with chronic non-cancer pain for participation in a program that combined the skills of internists, clinical pharmacists, and a psychiatrist. Patients were either receiving opioids or being considered for opioid therapy. The intervention consisted of structured clinical assessments, monthly follow-up, pain contracts, medication titration, and psychiatric consultation. Pain, mood, and function were assessed at baseline and 3 months using the Brief Pain Inventory (BPI), the Center for Epidemiological Studies-Depression Scale scale (CESD) and the Pain Disability Index (PDI). Patients were monitored for substance misuse. RESULTS: Eighty-five patients were enrolled. Mean age was 51 years, 60% were male, 78% were Caucasian, and 93% were receiving opioids. Baseline average pain was 6.5 on an 11 point scale. The average CESD score was 24.0, and the mean PDI score was 47.0. Sixty-three patients (73%) completed 3 month follow-up. Fifteen withdrew from the program after identification of substance misuse. Among those completing 3 month follow-up, the average pain score improved to 5.5 (p = 0.003). The mean PDI score improved to 39.3 (p < 0.001). Mean CESD score was reduced to 18.0 (p < 0.001), and the proportion of depressed patients fell from 79% to 54% (p = 0.003). Substance misuse was identified in 27 patients (32%). CONCLUSIONS: A primary care disease management program improved pain, depression, and disability scores over three months in a cohort of opioid-treated patients with chronic non-cancer pain. Substance misuse and depression were common, and many patients who had substance misuse identified left the program when they were no longer prescribed opioids. Effective care of patients with chronic pain should include rigorous assessment and treatment of these comorbid disorders and intensive efforts to insure follow up