An Entailment Relation for Reasoning on the Web

Reasoning on the Web is receiving an increasing attention because of emerging fields such as Web adaption and Semantic Web. Indeed, the advanced functionalities striven for in these fields call for reasoning capabilities. Reasoning on the Web, however, is usually done using existing techniques rarely fitting the Web. As a consequence, additional data processing like data conversion from Web formats (e.g. XML or HTML) into some other formats (e.g. classical logic terms and formulas) is often needed and aspects of the Web (e.g. its inherent inconsistency) are neglected. This article first gives requirements for an entailment tuned to reasoning on the Web. Then, it describes how classical logic’s entailment can be modified so as to enforce these requirements. Finally, it discusses how the proposed entailment can be used in applying logic programming to reasoning on the Web

Narrar la propia biografía después de un divorcio : notas de un estudio cualitativo de interés para la demografía

En este artículo se discuten algunos resultados de un estudio cualitativo sobre las trayectorias familiares que siguen hombres y mujeres que han vivido una ruptura de una unión en la que hubo hijos. Primero se presenta el diseño de la metodología cualitativa y luego se ofrecen algunos resultados del trabajo de campo realizado en áreas metropolitanas de España donde el divorcio tiene una intensidad mayor. Las narraciones de nuestros biógrafos y biógrafas permiten discutir a fondo el significado mutante de la familia y los vínculos afectivos en la llamada moderna sociedad líquida, y revisar de forma crítica tres conceptos básicos del análisis demográfico de las biografías de rupturas de unión: familia, la datación de los acontecimientos y los llamados factores determinantes.In this article some outcomes of a qualitative study on the familiar trajectories that follow men and women who have experienced a break-up of union in which there were children are discussed. The design of the qualitative methodology is first presented before showing some results of the fieldwork done in metropolitan areas of Spain where the divorce has a greater intensity. The narrations of our biographers allow us to discuss the meaning of the family and the affective ties in the so-called liquid modern society and to review three basic concepts of the demographic analysis of the biographies of union ruptures: family, timing of the events and the determinant factors.Dans cet article on discute quelques résultats d'une étude qualitative sur les trajectoires familiales qu'ils suivent des hommes et des femmes qui ont vécu une rupture d'une union dans laquelle il y a eu des enfants. On présente d'abord la conception de la méthodologie qualitative et on offre ensuite quelques résultats de la recherche effectué dans des secteurs métropolitains de l'Espagne où le divorce a une intensité plus grande. Les narrations de nos biographes permettent d'examiner en profondeur la signification mutant de la famille et les liens affectifs dans la moderne société liquide, et de réviser de manière critique trois concepts de base de l'analyse démographique des biographies de ruptures d'union: famille, datation des événements et facteurs déterminants

Deep lithospheric structures along the southern central Chile Margin from wide-angle P-wave modellilng

Crustal- and upper-mantle structures of the subduction zone in south central Chile, between 42 degrees S and 46 degrees S, are determined from seismic wide-angle reflection and refraction data, using the seismic ray tracing method to calculate minimum parameter models. Three profiles along differently aged segments of the subducting Nazca Plate were analysed in order to study subduction zone structure dependencies related to the age, that is, thermal state, of the incoming plate. The age of the oceanic crust at the trench ranges from 3 Ma on the southernmost profile, immediately north of the Chile triple junction, to 6.5 Ma old about 100 km to the north, and to 14.5 Ma old another 200 km further north, off the Island of Chiloe. Remarkable similarities appear in the structures of both the incoming as well as the overriding plate. The oceanic Nazca Plate is around 5 km thick, with a slightly increasing thickness northward, reflecting temperature changes at the time of crustal generation. The trench basin is about 2 km thick except in the south where the Chile Ridge is close to the deformation front and only a small, 800-m-thick trench infill could develop. In south central Chile, typically three quarters (1.5 km) of the trench sediments subduct below the decollement in the subduction channel. To the north and south of the study area, only about one quarter to one third of the sediments subducts, the rest is accreted above. Similarities in the overriding plate are the width of the active accretionary prism, 35-50 km, and a strong lateral crustal velocity gradient zone about 75-80 km landward from the deformation front, where landward upper-crustal velocities of over 5.0-5.4 km s<SU-1</SU decrease seaward to around 4.5 km s<SU-1</SU within about 10 km, which possibly represents a palaeo-backstop. This zone is also accompanied by strong intraplate seismicity. Differences in the subduction zone structures exist in the outer rise region, where the northern profile exhibits a clear bulge of uplifted oceanic lithosphere prior to subduction whereas the younger structures have a less developed outer rise. This plate bending is accompanied by strongly reduced rock velocities on the northern profile due to fracturing and possible hydration of the crust and upper mantle. The southern profiles do not exhibit such a strong alteration of the lithosphere, although this effect may be counteracted by plate cooling effects, which are reflected in increasing rock velocities away from the spreading centre. Overall there appears little influence of incoming plate age on the subduction zone structure which may explain why the M-w = 9.5 great Chile earthquake from 1960 ruptured through all these differing age segments. The rupture area, however, appears to coincide with a relatively thick subduction channel

The Vienna history Wiki: a collaborative knowledge platform for the city of Vienna

The Vienna City Archive and the Vienna City Library have joined forces with several other institutions in Vienna, Austria to create the "Wien Geschichte Wiki" (Vienna History Wiki), a knowledge platform for the history of Vienna with more than 34,000 articles and 120,000 visits per month. The wiki is powered by Semantic MediaWiki and serves not only as an online encyclopedia, based on a digitized printed publication for everybody to use and contribute to, but also as a central knowledge base for several administrative departments of the city administration. In a peer-review process, wiki edits are checked before they become visible. The paper highlights the unique aspects of the Vienna History Wiki related to content creation, governance structures and technology choices. A usage log analysis and an online survey have been carried out to gain first insights after six months of operation

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Peer reviewe

Paneth cells as a site of origin for intestinal inflammation.

The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity, causes Paneth cell dysfunction. As Atg16l1(HM) mice do not develop spontaneous intestinal inflammation, the mechanism(s) by which ATG16L1 contributes to disease remains obscure. Deletion of the unfolded protein response (UPR) transcription factor X-box binding protein-1 (Xbp1) in intestinal epithelial cells, the human orthologue of which harbours rare inflammatory bowel disease risk variants, results in endoplasmic reticulum (ER) stress, Paneth cell impairment and spontaneous enteritis. Unresolved ER stress is a common feature of inflammatory bowel disease epithelium, and several genetic risk factors of Crohn's disease affect Paneth cells. Here we show that impairment in either UPR (Xbp1(ΔIEC)) or autophagy function (Atg16l1(ΔIEC) or Atg7(ΔIEC)) in intestinal epithelial cells results in each other's compensatory engagement, and severe spontaneous Crohn's-disease-like transmural ileitis if both mechanisms are compromised. Xbp1(ΔIEC) mice show autophagosome formation in hypomorphic Paneth cells, which is linked to ER stress via protein kinase RNA-like endoplasmic reticulum kinase (PERK), elongation initiation factor 2α (eIF2α) and activating transcription factor 4 (ATF4). Ileitis is dependent on commensal microbiota and derives from increased intestinal epithelial cell death, inositol requiring enzyme 1α (IRE1α)-regulated NF-κB activation and tumour-necrosis factor signalling, which are synergistically increased when autophagy is deficient. ATG16L1 restrains IRE1α activity, and augmentation of autophagy in intestinal epithelial cells ameliorates ER stress-induced intestinal inflammation and eases NF-κB overactivation and intestinal epithelial cell death. ER stress, autophagy induction and spontaneous ileitis emerge from Paneth-cell-specific deletion of Xbp1. Genetically and environmentally controlled UPR function within Paneth cells may therefore set the threshold for the development of intestinal inflammation upon hypomorphic ATG16L1 function and implicate ileal Crohn's disease as a specific disorder of Paneth cells

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

Despite recent advances in our understanding of the pathogenesis of attaching and effacing (A/E) Escherichia coli infections, the mechanisms by which the host defends against these microbes are unclear. The goal of this study was to determine the role of goblet cell-derived Muc2, the major intestinal secretory mucin and primary component of the mucus layer, in host protection against A/E pathogens. To assess the role of Muc2 during A/E bacterial infections, we inoculated Muc2 deficient (Muc2−/−) mice with Citrobacter rodentium, a murine A/E pathogen related to diarrheagenic A/E E. coli. Unlike wildtype (WT) mice, infected Muc2−/− mice exhibited rapid weight loss and suffered up to 90% mortality. Stool plating demonstrated 10–100 fold greater C. rodentium burdens in Muc2−/− vs. WT mice, most of which were found to be loosely adherent to the colonic mucosa. Histology of Muc2−/− mice revealed ulceration in the colon amid focal bacterial microcolonies. Metabolic labeling of secreted mucins in the large intestine demonstrated that mucin secretion was markedly increased in WT mice during infection compared to uninfected controls, suggesting that the host uses increased mucin release to flush pathogens from the mucosal surface. Muc2 also impacted host-commensal interactions during infection, as FISH analysis revealed C. rodentium microcolonies contained numerous commensal microbes, which was not observed in WT mice. Orally administered FITC-Dextran and FISH staining showed significantly worsened intestinal barrier disruption in Muc2−/− vs. WT mice, with overt pathogen and commensal translocation into the Muc2−/− colonic mucosa. Interestingly, commensal depletion enhanced C. rodentium colonization of Muc2−/− mice, although colonic pathology was not significantly altered. In conclusion, Muc2 production is critical for host protection during A/E bacterial infections, by limiting overall pathogen and commensal numbers associated with the colonic mucosal surface. Such actions limit tissue damage and translocation of pathogenic and commensal bacteria across the epithelium