Observation of inertial energy cascade in interplanetary space plasma

We show in this article direct evidence for the presence of an inertial energy cascade, the most characteristic signature of hydromagnetic turbulence (MHD), in the solar wind as observed by the Ulysses spacecraft. After a brief rederivation of the equivalent of Yaglom's law for MHD turbulence, we show that a linear relation is indeed observed for the scaling of mixed third order structure functions involving Els\"asser variables. This experimental result, confirming the prescription stemming from a theorem for MHD turbulence, firmly establishes the turbulent character of low-frequency velocity and magnetic field fluctuations in the solar wind plasma

High efficiency coupling of photon pairs in practice

Multi-photon and quantum communication experiments such as loophole-free Bell tests and device independent quantum key distribution require entangled photon sources which display high coupling efficiency. In this paper we put forward a simple quantum theoretical model which allows the experimenter to design a source with high pair coupling efficiency. In particular we apply this approach to a situation where high coupling has not been previously obtained: we demonstrate a symmetric coupling efficiency of more than 80% in a highly frequency non-degenerate configuration. Furthermore, we demonstrate this technique in a broad range of configurations, i.e. in continuous wave and pulsed pump regimes, and for different nonlinear crystals

Persistence of small-scale anisotropy of magnetic turbulence as observed in the solar wind

The anisotropy of magnetophydrodynamic turbulence is investigated by using solar wind data from the Helios 2 spacecraft. We investigate the behaviour of the complete high-order moment tensors of magnetic field increments and we compare the usual longitudinal structure functions which have both isotropic and anisotropic contributions, to the fully anisotropic contribution. Scaling exponents have been extracted by an interpolation scaling function. Unlike the usual turbulence in fluid flows, small-scale magnetic fluctuations remain anisotropic. We discuss the radial dependence of both anisotropy and intermittency and their relationship.Comment: 7 pages, 2 figures, in press on Europhys. Let

Velocity fluctuations in polar solar wind: a comparison between different solar cycles

The polar solar wind is a fast, tenuous and steady flow that, with the exception of a relatively short phase around the Sun's activity maximum, fills the high-latitude heliosphere. The polar wind properties have been extensively investigated by Ulysses, the first spacecraft able to perform in-situ measurements in the high-latitude heliosphere. The out-of-ecliptic phases of Ulysses cover about seventeen years. This makes possible to study heliospheric properties at high latitudes in different solar cycles. In the present investigation we focus on hourly- to daily-scale fluctuations of the polar wind velocity. Though the polar wind is a quite uniform flow, fluctuations in its velocity do not appear negligible. A simple way to characterize wind velocity variations is that of performing a multi-scale statistical analysis of the wind velocity differences. Our analysis is based on the computation of velocity differences at different time lags and the evaluation of statistical quantities (mean, standard deviation, skewness, and kurtosis) for the different ensembles. The results clearly show that, though differences exist in the three-dimensional structure of the heliosphere between the investigated solar cycles, the velocity fluctuations in the core of polar coronal holes exhibit essentially unchanged statistical properties

On the probability distribution function of small scale interplanetary magnetic field fluctuations

In spite of a large number of papers dedicated to study MHD turbulence in the solar wind there are still some simple questions which have never been sufficiently addressed like: a)do we really know how the magnetic field vector orientation fluctuates in space? b) what is the statistics followed by the orientation of the vector itself? c) does the statistics change as the wind expands into the interplanetary space? A better understanding of these points can help us to better characterize the nature of interplanetary fluctuations and can provide useful hints to investigators who try to numerically simulate MHD turbulence. This work follows a recent paper presented by the same authors. This work follows a recent paper presented by some of the authors which shows that these fluctuations might resemble a sort of random walk governed by a Truncated Leevy Flight statistics. However, the limited statistics used in that paper did not allow final conclusions but only speculative hypotheses. In this work we aim to address the same problem using a more robust statistics which on one hand forces us not to consider velocity fluctuations but, on the other hand allows us to establish the nature of the governing statistics of magnetic fluctuations with more confidence. In addition, we show how features similar to those found in the present statistical analysis for the fast speed streams of solar wind, are qualitatively recovered in numerical simulations of the parametric instability. This might offer an alternative viewpoint for interpreting the questions raised above.Comment: 25pag, 20 jpg small size figures. In press on "ANnales Geophysicae" (September 2004

Guido Calabresi on Torts: Italian Courts and the Cheapest Cost Avoider

Guido Calabresi proposed to replace the dominating paradigm of fault with simpler strict liability rules that put liability on the most appropriate actors (the cheapest cost avoiders). Assuming that the objective function of the tort system is the mimimization of the sum of the injury and injury avoidance costs associated with accidents (primary costs), risk-spreading costs (secondary costs), and administrative costs (tertiary costs), he suggested that the adoption of strict liability, targeted to specified activities, would achieve the goal of cost minimization. The core of an extremely richer message was that the cheapest cost avoider test would abate the administrative costs of courts. Moreover, the manufacturers' ability to spread the costs of strict liability through the prices charged for their products would effectively insure product users against the risks of injury. This masterpiece of normative analysis has deployed an ever increasing influence on thinking about tort law, not only in the US but also in Europe. This paper aims to trace the impact of Calabresi's ideas on Italian case-law. After a brief introduction, section 2 outlines the methodology adopted in the research. The following sections, 3 to 13, present (and cursorily comment on) the opinions which display the influence of Calabresi's thinking. Section 14 summarizes and concludes

An improved microtiter plate assay to monitor the oxidative burst in monocot and dicot plant cell suspension cultures

BACKGROUND: A screening method for elicitor and priming agents does not only allow detecting new bioactive substances, it can also be used to understand structure–function relationships of known agents by testing different derivatives of them. This can not only provide new lead compounds for the development of novel, more environment-benign, bio-based agro-chemicals, it may eventually also lead to a better understanding of defense mechanisms in plants. Reactive oxygen species (ROS) are sensitive indicators of these mechanisms but current assay formats are not suitable for multiplex screening, in particularly not in the case of monocot systems. RESULTS: Here we describe continuous monitoring of ROS in 96-well microtiter plates using the chemiluminescent probe L012, a luminol derivative producing chemiluminescence when oxidised by ROS like hydrogen peroxide, superoxide, or hydroxyl radical that can thus be used as an indicator for these ROS. We were able to measure ROS in both monocot (Oryza sativa) and dicot (Medicago truncatula) cell suspension cultures and record dose dependencies for the carbohydrate elicitors and priming agents ulvan and chitosan at low substrate concentrations (0.3–2.5 µg/ml). The method was optimized in terms of cell density, L012 concentration, and pre-incubation time. In contrast to the single peak observed using a cuvette luminometer, the improved method revealed a double burst in both cell systems during the 90-min measuring period, probably due to the detection of multiple ROS rather than only H2O2. CONCLUSION: We provide a medium throughput screening method for monocot and dicot suspension-cultured cells that enables direct comparison of monocot and dicot plant systems regarding their reaction to different signaling molecules.<br

Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectable non-small cell lung cancer (NSCLC). Methods. From January 2016 to December 2016, 44 patients affected by non-small cell lung cancer referred to our oncology day hospital were progressively analyzed. The patients were treated with oral vinorelbine 30 mg x 3/wk or 40 mg x 3/wk meaning one day on and one day off. The patients were older than 60, stage IIIB or IV, ECOG PS ≥ 1, and have at least one important comorbidity (renal, hepatic, or cardiovascular disease). The schedule was based on ECOG-PS and comorbidities. The primary endpoint was progression-free survival (PFS). PFS was used to compare patients based on different scheduled dosage (30 or 40 mg x3/weekly) and age (more or less than 75 years old) as exploratory analysis. We also evaluated as secondary endpoint toxicity according to Common Toxicity Criteria Version 2.0. Results. Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. The median overall survival (OS) was 12 months. The disease control rate (DCR) achieved 63%. The median PFS was 9 months. A significant difference in PFS was detected comparing patients aged below with those over 75, and the HR value was 0.72 (p<0.05). Not significant was the difference between groups with different schedules. Conclusions. This study confirmed the safety profile of metronomic vinorelbine and its applicability for patients unfit for standard chemotherapies and adds the possibility of considering this type of schedule not only for very elderly patients