Grammar induction for mildly context sensitive languages using variational Bayesian inference

The following technical report presents a formal approach to probabilistic minimalist grammar induction. We describe a formalization of a minimalist grammar. Based on this grammar, we define a generative model for minimalist derivations. We then present a generalized algorithm for the application of variational Bayesian inference to lexicalized mildly context sensitive language grammars which in this paper is applied to the previously defined minimalist grammar

The quantification of drug-caused mortality and morbidity in Australia, 1998

The aetiological fraction methodology and the associated fraction estimates enable estimation of the proportion of cases of an illness or injury that can be attributed to a risk factor. This report presents aetiological fraction estimates attributing deaths and hospital separations resulting from a range of specific illnesses or injuries to tobacco, alcohol and illicit drugs. The fractions represent a revision of the fractions originally presented by Holman et al. (1990) and later revised by English et al. (1995). Also presented here are estimates of 1998 mortality and 1997–98 hospital separations attributable to alcohol, tobacco and illicit drugs based on the revised fractions

pH-independent immediate release polymethacrylate formulations : an observational study

Using Eudragit (R) E PO (EudrE) as a polymethacrylate carrier, the aim of the study was to develop a pH-independent dosage form containing ibuprofen (IBP) as an active compound via chemical modification of the polymer (i.e. quaternization of amine function) or via the addition of dicarboxylic acids (succinic, glutaric and adipic acid) to create a pH micro-environment during dissolution. Biconvex tablets (diameter: 10mm; height: 5mm) were produced via hot melt extrusion and injection molding. In vitro dissolution experiments revealed that a minimum of 25% of quaternization was sufficient to partially (up to pH 5) eliminate the pH-dependent effect of the EudrE/IBP formulation. The addition of dicarboxylic acids did not alter IBP release in a pH 1 and 3 medium as the dimethyl amino groups of EudrE are already fully protonated, while in a pH 5 solvent IBP release was significantly improved (cf. from 0% to 92% release after 1h dissolution experiments upon the addition of 20wt.% succinic acid). Hence, both approaches resulted in a pH-independent (up to pH 5) immediate release formulation. However, the presence of a positively charged polymer induced stability issues (recrystallization of API) and the formulations containing dicarboxylic acids were classified as mechanically unstable. Hence, further research is needed to obtain a pH-independent immediate release formulation while using EudrE as a polmethacrylate carrier

A single trapped ion in a finite range trap

This paper presents a method to describe dynamics of an ion confined in a realistic finite range trap. We model this realistic potential with a solvable one and we obtain dynamical variables (raising and lowering operators) of this potential. We consider coherent interaction of this confined ion in a finite range trap and we show that its center-of-mass motion steady state is a special kind of nonlinear coherent states. Physical properties of this state and their dependence on the finite range of potential are studied

Role of lysozyme inhibitors in the virulence of avian pathogenic Escherichia coli

Lysozymes are key effectors of the animal innate immunity system that kill bacteria by hydrolyzing peptidoglycan, their major cell wall constituent. Recently, specific inhibitors of the three major lysozyme families occuring in the animal kingdom (c-, g- and i-type) have been discovered in Gram-negative bacteria, and it has been proposed that these may help bacteria to evade lysozyme mediated lysis during interaction with an animal host. Escherichia coli produces two inhibitors that are specific for c-type lysozyme (Ivy, Inhibitor of vertebrate lysozyme; MliC, membrane bound lysozyme inhibitor of c-type lysozyme), and one specific for g-type lysozyme (PliG, periplasmic lysozyme inhibitor of g-type lysozyme). Here, we investigated the role of these lysozyme inhibitors in virulence of Avian Pathogenic E. coli (APEC) using a serum resistance test and a subcutaneous chicken infection model. Knock-out of mliC caused a strong reduction in serum resistance and in in vivo virulence that could be fully restored by genetic complementation, whereas ivy and pliG could be knocked out without effect on serum resistance and virulence. This is the first in vivo evidence for the involvement of lysozyme inhibitors in bacterial virulence. Remarkably, the virulence of a ivy mliC double knock-out strain was restored to almost wild-type level, and this strain also had a substantial residual periplasmic lysozyme inhibitory activity that was higher than that of the single knock-out strains. This suggests the existence of an additional periplasmic lysozyme inhibitor in this strain, and indicates a regulatory interaction in the expression of the different inhibitors

Tectonics and crustal evolution

We thank the Natural Environment Research Council (grants NE/J021822/1 and NE/K008862/1) for funding.The continental crust is the archive of Earth's history. Its rock units record events that are heterogeneous in time with distinctive peaks and troughs of ages for igneous crystallization, metamorphism, continental margins, and mineralization. This temporal distribution is argued largely to reflect the different preservation potential of rocks generated in different tectonic settings, rather than fundamental pulses of activity, and the peaks of ages are linked to the timing of supercontinent assembly. Isotopic and elemental data from zircons and whole rock crustal compositions suggest that the overall growth of continental crust (crustal addition from the mantle minus recycling of material to the mantle) has been continuous throughout Earth's history. A decrease in the rate of crustal growth ca. 3.0 Ga is related to increased recycling associated with the onset of plate tectonics. We recognize five stages of Earth's evolution: (1) initial accretion and differentiation of the core/mantle system within the first few tens of millions of years; (2) generation of crust in a pre-plate tectonic regime in the period prior to 3.0 Ga; (3) early plate tectonics involving hot subduction with shallow slab breakoff over the period from 3.0 to 1.7 Ga; (4) Earth's middle age from 1.7 to 0.75 Ga, characterized by environmental, evolutionary, and lithospheric stability; (5) modern cold subduction, which has existed for the past 0.75 b.y. Cycles of supercontinent formation and breakup have operated during the last three stages. This evolving tectonic character has likely been controlled by secular changes in mantle temperature and how that impacts on lithospheric behavior. Crustal volumes, reflecting the interplay of crust generation and recycling, increased until Earth's middle age, and they may have decreased in the past ∼1 b.y.Publisher PDFPeer reviewe

In vivo1H-MR spectroscopy of the human heart

4. Conclusions: Combined respiratory and cardiac triggering improves the localization accuracy and spectral quality in cardiac1H-MRS dramatically leading to substantially increased spectral reproducibility. The best practical realization of double triggering turned out to be the use of the ECG amplitude when making use of the fact that it is modulated by respiration. In spite of the spectral quality achieved in most subjects, we still fail to record satisfactory spectra in a minority of subjects. The reasons for this are not understood at present but must be some particulars of either a given subject or the experimental setup. The cardiac1H-MR spectra contain quantifiable contributions from creatine, TMA, lipids, and probably taurine. It is possible that the spectral contributions of creatine are subject to dipolar coupling similar to the observations for skeletal muscl

Prospectus, November 14, 1979

ILLINOIS WILL END CANTEEN CONTRACT; Week in Review: Across the globe, In the nation, Throughout the state; Briefs: Reserve courses, Apply for study in Scandinavia, Ped emergency workshop here, All they want is a fair fight, Reader\u27s audition, There is life after a heart attack; Faculty Focus: Education is more than numbers and chemicals; Letters to the Editor: MTD said unfair, Contestants thanked, Advertisers pleased; Candidates guide listed; Concern expressed; Classifieds; Campus Question: If the presedential election were today, who would you vote for?; Girls V-ball impressive against chammps; Flu epidemic flattens Elam; WPCD claims IM crown; Defense keys victory; Freddy rebounds; Fast Freddy Contesthttps://spark.parkland.edu/prospectus_1979/1004/thumbnail.jp