deep learning based production forecasting in manufacturing a packaging equipment case study

Abstract We propose a Deep Learning (DL)-based approach for production performance forecasting in fresh products packaging. On the one hand, this is a very demanding scenario where high throughput is mandatory; on the other, due to strict hygiene requirements, unexpected downtime caused by packaging machines can lead to huge product waste. Thus, our aim is predicting future values of key performance indexes such as Machine Mechanical Efficiency (MME) and Overall Equipment Effectiveness (OEE). We address this problem by leveraging DL-based approaches and historical production performance data related to measurements, warnings and alarms. Different architectures and prediction horizons are analyzed and compared to identify the most robust and effective solutions. We provide experimental results on a real industrial case, showing advantages with respect to current policies implemented by the industrial partner both in terms of forecasting accuracy and maintenance costs. The proposed architecture is shown to be effective on a real case study and it enables the development of predictive services in the area of Predictive Maintenance and Quality Monitoring for packaging equipment providers

Sutureless aortic valve replacement in high risk patients neutralizes expected worse hospital outcome: A clinical and economic analysis

Background: Aortic valve replacement (AVR) by sutureless prostheses is changing surgeon options, although which patients benefit most, as well as their possible economic impact is still to be defined. Methods: Perceval-S prosthesis (LivaNova) is reserved, at the documented Institution, for patients at perceived high surgical risk. This retrospective analysis of outcome and resource consumption compared Perceval with other tissue valves. To clarify the comparison, only patients respecting ‘instructions-for- use’ of Perceval were reviewed. Inclusion criteria: > 65 years, +/– coronary artery bypass grafting, patent foramen ovale closure or myectomy. Exclusion criteria: bicuspid, combined valve or aortic sur- gery. Costs were calculated per patient on a daily basis including preoperative tests, operating costs (hourly basis), disposables, drugs, blood components and personnel. Results: The sutureless group (SU-AVR) had a higher risk profile than the sutured group (ST-AVR). Cardiopulmonary bypass (CPB) and cross-clamp times were significantly shorter in SU-AVR (isolated AVR: cross-clamp 52.9 ± 12.6 vs. 69 ± 15.3 min, p < 0.001; CPB 79.4 ± 20.3 vs. 92.7 ± 18.2 min, p < 0.001). Hospital mortality was 0.9% in SU-AVR and nil in ST-AVR, p = 0.489; intubation 7 (IQR 5–10.7) and 7 h (IQR 5–9), p = 0.785; intensive care unit 1 (IQR 1–1) and 1 day (IQR 1–1), p = 0.258; ward stay 5.5 (IQR 4–7) and 5 days (IQR 4–6), p = 0.002; pacemaker 5.7% (6/106) and 0.9% (1/109), p = 0.063, respectively. Hospital costs (excluding the prosthesis) were $12,825 (IQR 11,733–15,334) for SU-AVR and$12,386 (IQR 11,217–14,230) in ST-AVR, p = 0.055. Conclusions: Despite higher operative risks in SU-AVR, hospital mortality, morbidity and resource consumption did not differ. Operative times were shorter with the sutureless device and this improve- ment, along with more frequent ministernotomy, may have improved many postoperative aims.

Sightings and successful reproduction of allochthonous reptiles in Calabria

This paper reports information about the presence of three allochthonous reptiles species in Calabria: Testudo marginata, Trachemys scripta elegans and Chamaeleo chamaeleon. The first one was found in three sites located in the Catena Costiera Massif and in the Crati Valley (Northern Calabria). The slider turtle was found in seven different sites throughout all the region. It massively colonised the Angitola artificial lake: here, this turtle lives in natural conditions and its reproduction was confirmed by the presence of nests, eggs and hatchlings. C. chamaeleon is present in sandy coastal habitats near Palmi and Gioia Tauro (Southern Calabria). From a conservationistic point of view, serious damages to autochtonous species could be caused by the spreading of T. scripta elegans: this species has already determined the local extinction of Angitola’s Emys orbicularis populations

Morphological aspects and Cox-2 expression after exposure to 780-nm laser therapy in injured skeletal muscle: an in vivo study

Background:The effectiveness of low-level laser therapy in muscle regeneration is still not well known. Objective: To investigate the effects of laser irradiation during muscle healing.Method: For this purpose, 63 rats were distributed to 3 groups: non-irradiated control group (CG); group irradiated at 10 J/cm² (G10); and group irradiated at 50 J/cm² (G50). Each group was divided into 3 different subgroups (n=7), and on days 7, 14 and 21 post-injury the rats were sacrificed.Results:Seven days post-surgery, the CG showed destroyed zones and extensive myofibrillar degeneration. For both treated groups, the necrosis area was smaller compared to the CG. On day 14 post-injury, treated groups demonstrated better tissue organization, with newly formed muscle fibers compared to the CG. On the 21st day, the irradiated groups showed similar patterns of tissue repair, with improved muscle structure at the site of the injury, resembling uninjured muscle tissue organization. Regarding collagen deposition, the G10 showed an increase in collagen synthesis. In the last period evaluated, both treated groups showed statistically higher values in comparison with the CG. Furthermore, laser irradiation at 10 J/cm2 produced a down-regulation of cyclooxygenase 2 (Cox-2) immunoexpression on day 7 post-injury. Moreover, Cox-2 immunoexpression was decreased in both treated groups on day 14.Conclusions:Laser therapy at both fluencies stimulated muscle repair through the formation of new muscle fiber, increase in collagen synthesis, and down-regulation of Cox-2 expression.Universidade Federal de São Carlos Departamento de FisioterapiaUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de CirurgiaUniversidade de São Paulo Departamento de Biomecânica, Medicina e Reabilitação do Sistema LocomotorUniversidade Federal de São Paulo (UNIFESP) Departamento de BiociênciasUNIFESP, Depto. de BiociênciasSciEL

Estudo de ocorrência de mineralizações de tecidos moles em radiografia panorâmica de pacientes atendidos em uma clínica escola de odontologia

Trabalho de Conclusão de Curso, apresentado para obtenção do grau de Cirurgião Dentista no curso de Odontologia da Universidade do Extremo Sul Catarinense – UNESCA radiografia panorâmica permite a avaliação de áreas de tecido mole adjacentes ao sistema estomatognático. As mais frequentes calcificações descritas na literatura são as calcificações do ligamento estilóide, mineralização da cartilagem da tireoide, os ateromas de artéria carótida, os tonsilólitos, calcificação da cartilagem tritícea, os sialolitos e mineralização de linfonodos. Este trabalho tem por objetivo realizar a análise documental de radiografias panorâmicas digitais realizadas em uma clínica escola em uma Universidade do Sul de Santa Catarina, com intuito de verificar a ocorrência de mineralizações de tecidos moles na região bucomaxilofacial. Foram selecionadas e analisadas 192 radiografias panorâmicas digitais em pacientes com a idade superior a 40 anos que procuraram atendimento odontológico entre os ano de 2015 à 2018, as imagens foram avaliadas por um observador. Foram coletados dados demográficos de pacientes que apresentaram mineralizações em tecido mole. O gênero feminino e a idade de 60 a 69 anos foram as mais acometidas. Encontraram-se 206 mineralizações sendo 59,90 % do ligamento estilóide, 11,98% da cartilagem da tireoide, 9,38% suspeita de ateroma, 9,38% de tonsilólito, 6,77% de mineralização da cartilagem da tritícea, 5,73% de sialolito e 4,17% de mineralização de linfonodos. Não houve ocorrência de calcificações da cartilagem da epiglote, antrolito e rinolito. O não preenchimento da anamnese dos prontuários eletrônicos impossibilitou a associação com a variável comorbidade

Prognostic value of lymph node ratio in patients with pathological N1 non-small cell lung cancer: A systematic review with meta-analysis

Background: Non-small cell lung cancer (NSCLC) patients with N1 disease have variable outcomes, and additional prognostic factors are needed. The number of positive lymph nodes (LNs) has been proposed as a prognostic indicator. However, the number of positive LNs depends on the number of LNs examined from the resection specimen. The lymph node ratio (LNR) can circumvent this limitation. The purpose of this study is to evaluate LNR as a predictor of survival and recurrence in patients with pathologic N1 NSCLC. Methods: We systematically reviewed studies published before March 17, 2016, on the prognostic value of LNR in patients with pathologic N1 NSCLC. The hazard ratios (HRs) and their 95% confidence intervals (CIs) were used to combine the data. We also evaluated heterogeneity and publication bias. Results: Five studies published between 2010 and 2014 were eligible for this systematic review with metaanalysis. The total number of patients included was 6,130 ranging from 75 to 4,004 patients per study. The combined HR for all eligible studies evaluating the overall survival (OS) and disease-free survival (DFS) of N1 LNR in patients with pathologic N1 NSCLC was 1.53 (95% CI: 1.22-1.85) and 1.64 (95% CI: 1.19-2.09), respectively. We found no heterogeneity and publication bias between the reports. Conclusions: LNR is a worthy predictor of survival and cancer recurrence in patients with pathological N1 NSCLC

Echocardiographic features and outcome of restrictive foramen ovale in fetuses with and without cardiac malformations. literature review

Foramen ovale is a small communication between the left and the right atrium and its restriction is a rare congenital heart anomaly. There is no consensus on diagnosis and management of fetal restrictive foramen ovale (RFO). In our paper we included 11 studies about fetuses affected by isolated RFO, RFO with D-Transposition of the Great Arteries (dTGA) and RFO with hypoplastic left heart syndrome (HLHS). While fetuses affected from HLHS and dTGA with RFO have a poor prognosis, premature RFO in an otherwise structurally normal heart, if found in later gestation, have an overall good outcome

SARS-CoV-2 infection in pregnancy. Clues and proof of adverse outcomes

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 research, the clinical course of maternal infection, the vertical transmission and the neonatal outcomes have not been completely understood yet. The aim of our study was to investigate the association between SARS-CoV-2 infection, obstetric outcomes and vertical transmission. Methods: A prospective observational study was performed, enrolling unvaccinated pregnant patients positive for SARS-CoV-2 (cases) and matched with uninfected pregnant women (controls). Maternal and neonatal nasopharyngeal swabs, maternal and cord blood, amniotic fluid and placenta tissue samples were collected; blood samples were tested for anti-S and anti-N antibodies, and histologic examination of placental tissues was performed. Results: The cases showed a significant association with the development of some obstetric complications, such as intrauterine growth restriction and pregnancy-associated hypothyroidism and diabetes, as compared to controls; their newborns were more likely to have a low birth weight and an arterial umbilical pH less than 7. The viral genome was detected in maternal and cord blood and placental samples in six cases. Conclusions: Pregnant women positive for SARS-CoV-2 infection are more likely to develop severe obstetric outcomes; their newborns could have a low birth weight and arterial pH. Vertical transmission seems a rare event, and further investigation is strongly needed