Open-Access-Strategie für Berlin: wissenschaftliche Publikationen für jedermann zugänglich und nutzbar machen : Nachbereitung einer Veranstaltung und Desiderata

Am 13.10.2014 kamen Vertreter_innen verschiedener Universitäten, Hochschulen, Kulturerbe- und Forschungseinrichtungen sowie Open-Access-Initiativen zu der Veranstaltung "Open-Access-Strategie für Berlin" zusammen, die auf Initiative des Berliner Open-Access-Netzwerks durchgeführt wurde, um den Status quo von Open Access in Berlin darzustellen, Lücken aufzuzeigen und Bedarfe zu erörtern. Im vorliegenden Beitrag werden der Hintergrund und die wesentlichen Ergebnisse der Veranstaltung knapp zusammengefasst sowie Desiderata für eine künftige Berliner Open-Access-Strategie formuliert

Surgery of secondary mitral insufficiency in patients with impaired left ventricular function

<p>Abstract</p> <p>Background</p> <p>Secondary mitral insufficiency (SMI) is an indicator of a poor prognosis in patients with ischemic and dilated cardiomyopathies. Numerous studies corroborated that mitral valve (MV) surgery improves survival and may be an alternative to heart transplantation in this group of patients.</p> <p>The aim of the study was to retrospectively analyze the early and mid-term clinical results after MV repair resp. replacement in patients with moderate-severe to severe SMI and left ventricular ejection fraction (LVEF) below 35%.</p> <p>Methods</p> <p>We investigated 40 patients with poor LVEF (mean, 28 ± 5%) and SMI who underwent MV repair (n = 26) resp. replacement (n = 14) at the University Hospital Muenster from January 1994 to December 2005. All patients were on maximized heart failure medication. 6 pts. had prior coronary artery bypass grafts (CABG). Twenty-seven patients were in New York Heart Association (NYHA) class III and 13 were in class IV. Eight patients were initially considered for transplantation. During the operation, 14 pts had CABG for incidental disease and 8 had tricuspid valve repair. Follow-up included echocardiography, ECG, and physician's examination and was completed in 90% among survivors. Additionally, the late results were compared with the survival after orthotope heart transplantation (oHTX) in adults with ischemic or dilated cardiomyopathies matched to the same age and time period (148 patients).</p> <p>Results</p> <p>Three operative deaths (7.5%) occurred as a result of left ventricular failure in one and multiorgan failure in two patients. There were 14 late deaths, 2 to 67 months after MV procedure. Progress of heart failure was the main cause of death. 18 patients who were still alive took part on the follow-up examination. At a mean follow-up of 50 ± 34 (2–112) months the NYHA class improved significantly from 3.2 ± 0.5 to 2.2 ± 0.4 (p < 0.001). The LVEF improved significantly from 29 ± 5% to 39 ± 16 (p < 0.05). There were no differences in survival after MV repair or replacement. The 1-, 3-, 5-year survival rates in the study group were 80%, 58% and 55% respectively. In the group of patients after oHTX the survival was accordingly 72%, 68%, 66% (p > 0.05).</p> <p>Conclusion</p> <p>High risk mitral valve surgery in patients with cardiomyopathy and SMI offers a real mid-term alternative method of treatment of patients in drug refractory heart failure with similar survival in comparison to heart transplantation.</p

Recommendations for the Open Access Transition: Strategic and practical anchorage of Open Access in informational provisioning of research institutions; Recommendations of the Ad-hoc-group Open-Access-Gold in the priority initiative “Digital Information” of the Alliance of Science Organizations in Germany

The following “Recommendations for Open Access transition” have been compiled by the Ad-hoc workgroup “Open-Access-Gold” in the priority initiative “Digital Information” of the Alliance of Science Organizations in Germany . They are based on “Positions on creating an Open Access publication market which is scholarly adequate” as mapped out by the workgroup. They mainly address academic libraries as well as publishing houses and other actors in the field of scientific publishing. The recommendations are designed to help find orientation for strategic and practical anchorage of Open Access in the information provisioning of scholarly institutions

PEER D2.1 Draft report on the provision of usage data and manuscript deposit procedures for publishers and repository managers

The report on the provision of usage data and manuscript deposit procedures for publishers and repository managers sets out to establish a workflow for depositing stage-2 outputs in and harvesting logfiles from repositories to enable the research, conducted in work packages 4, 5, 6 & 7. It sets out an overall framework for including repositories, whereby a critical mass of content is made available in designated repositories to provide access to users

Helmholtz Open Science Workshop „Zugang zu und Nachnutzung von wissenschaftlicher Software“ #hgfos16, Report; November 2016

Der Report des Helmholtz Open Science Workshops „Zugang zu und Nachnutzung von wissenschaftlicher Software“ #hgfos16 behandelt die Themen Standards und Qualitätssicherung; Reproduzierbarkeit; Lizenzierung und weitere rechtliche Aspekte; Zitation und Anerkennung; Sichtbarkeit und Modularität; Geschäftsmodelle; Personal, Ausbildung, Karrierewege. Diese Themen sind eng miteinander verzahnt. Für jeden Themenbereich werden jeweils die Relevanz, Fragestellungen, Herausforderungen, mögliche Lösungsansätze und Handlungsempfehlungen betrachtet

Functional analysis of structural variants in single cells using Strand-seq

Somatic structural variants (SVs) are widespread in cancer, but their impact on disease evolution is understudied due to a lack of methods to directly characterize their functional consequences. We present a computational method, scNOVA, which uses Strand-seq to perform haplotype-aware integration of SV discovery and molecular phenotyping in single cells by using nucleosome occupancy to infer gene expression as a readout. Application to leukemias and cell lines identifies local effects of copy-balanced rearrangements on gene deregulation, and consequences of SVs on aberrant signaling pathways in subclones. We discovered distinct SV subclones with dysregulated Wnt signaling in a chronic lymphocytic leukemia patient. We further uncovered the consequences of subclonal chromothripsis in T cell acute lymphoblastic leukemia, which revealed c-Myb activation, enrichment of a primitive cell state and informed successful targeting of the subclone in cell culture, using a Notch inhibitor. By directly linking SVs to their functional effects, scNOVA enables systematic single-cell multiomic studies of structural variation in heterogeneous cell populations

Ex vivo drug response profiling for response and outcome prediction in hematologic malignancies: the prospective non-interventional SMARTrial

Ex vivo drug response profiling is a powerful tool to study genotype-drug response associations and is being explored as a tool set for precision medicine in cancer. Here we conducted a prospective non-interventional trial to investigate feasibility of ex vivo drug response profiling for treatment guidance in hematologic malignancies (SMARTrial, NCT03488641 ). The primary endpoint to provide drug response profiling reports within 7 d was met in 91% of all study participants (N = 80). Secondary endpoint analysis revealed that ex vivo resistance to chemotherapeutic drugs predicted chemotherapy treatment failure in vivo. We confirmed the predictive value of ex vivo response to chemotherapy in a validation cohort of 95 individuals with acute myeloid leukemia treated with daunorubicin and cytarabine. Ex vivo drug response profiles improved ELN-22 risk stratification in individuals with adverse risk. We conclude that ex vivo drug response profiling is clinically feasible and has the potential to predict chemotherapy response in individuals with hematologic malignancies beyond clinically established genetic markers

Three New Eclipsing White-dwarf - M-dwarf Binaries Discovered in a Search for Transiting Planets Around M-dwarfs

We present three new eclipsing white-dwarf / M-dwarf binary systems discovered during a search for transiting planets around M-dwarfs. Unlike most known eclipsing systems of this type, the optical and infrared emission is dominated by the M-dwarf components, and the systems have optical colors and discovery light curves consistent with being Jupiter-radius transiting planets around early M-dwarfs. We detail the PTF/M-dwarf transiting planet survey, part of the Palomar Transient Factory (PTF). We present a Graphics Processing Unit (GPU)-based box-least-squares search for transits that runs approximately 8X faster than similar algorithms implemented on general purpose systems. For the discovered systems, we decompose low-resolution spectra of the systems into white-dwarf and M-dwarf components, and use radial velocity measurements and cooling models to estimate masses and radii for the white dwarfs. The systems are compact, with periods between 0.35 and 0.45 days and semimajor axes of approximately 2 solar radii (0.01 AU). We use the Robo-AO laser guide star adaptive optics system to tentatively identify one of the objects as a triple system. We also use high-cadence photometry to put an upper limit on the white dwarf radius of 0.025 solar radii (95% confidence) in one of the systems. We estimate that 0.08% (90% confidence) of M-dwarfs are in these short-period, post-common-envelope white-dwarf / M-dwarf binaries where the optical light is dominated by the M-dwarf. Similar eclipsing binary systems can have arbitrarily small eclipse depths in red bands and generate plausible small-planet-transit light curves. As such, these systems are a source of false positives for M-dwarf transiting planet searches. We present several ways to rapidly distinguish these binaries from transiting planet systems.Comment: 14 pages, 14 figures, submitted to Ap