Diagnosis of an anaerobic pond treating temperate domestic wastewater: An alternative sludge strategy for small works

An anaerobic pond (AP) for treatment of temperate domestic wastewater has been studied as a small works sludge management strategy to challenge existing practice which comprises solids separation followed by open sludge storage, for up to 90 days. During the study, effluent temperature ranged between 0.1 °C and 21.1 °C. Soluble COD production was noted in the AP at effluent temperatures typically greater than 10 °C and was coincident with an increase in effluent volatile fatty acids (VFA) concentration, which is indicative of anaerobic degradation. Analysis from ports sited along the AP's length, demonstrated VFA to be primarily formed nearest the inlet where most solids deposition initially incurred, and confirmed the anaerobic reduction of sludge within this chamber. Importantly, the sludge accumulation rate was 0.06 m3 capita−1 y−1 which is in the range of APs operated at higher temperatures and suggests a de-sludge interval of 2.3–3.8 years, up to 10 times longer than current practice for small works. Coincident with the solids deposition profile, biogas production was predominantly noted in the initial AP section, though biogas production increased further along the AP's length following start-up. A statistically significant increase in mean biogas production of greater than an order of magnitude was measured between winters (t(n=19) = 5.52, P < 0.001) demonstrating continued acclimation. The maximum methane yield recorded was 2630 mgCH4 PE−1 d−1, approximately fifty times greater than estimated from sludge storage (57 mgCH4 PE−1 d−1). Anaerobic ponds at small works can therefore enable sludge reduction and longer sludge holding times than present thus offsetting tanker demand whilst reducing fugitive methane emissions currently associated with sludge storage, and based on the enhanced yield noted, could provide a viable opportunity for local energy generation

Physical Activity and Hippocampal Sub-Region Structure in Older Adults with Memory Complaints.

BackgroundPhysical activity (PA) plays a major role in maintaining cognition in older adults. PA has been shown to be correlated with total hippocampal volume, a memory-critical region within the medial temporal lobe (MTL). However, research on associations between PA and MTL sub-region integrity is limited.ObjectiveTo examine the relationship between PA, MTL thickness, and its sub-regions, and cognitive function in non-demented older adults with memory complaints.MethodsTwenty-nine subjects aged ≥60 years, with memory complaints were recruited for this cross-sectional study. PA was tracked for 7 days using accelerometers, and average number of steps/day determined. Subjects were categorized into two groups: those who walked ≤4000 steps/day (lower PA) and those with &gt;4000 steps/day (higher PA). Subjects received neuropsychological testing and 3T MRI scans. Nonparametric ANCOVAs controlling for age examined differences between the two groups.ResultsTwenty-six subjects aged 72.7(8.1) years completed the study. The higher PA group (n = 13) had thicker fusiform gyrus (median difference = 0.11 mm, effect size (ES) = 1.43, p = 0.001) and parahippocampal cortex (median difference = 0.12 mm, ES = 0.93, p = 0.04) compared to the lower PA group. The higher PA group also exhibited superior performance in attention and information-processing speed (median difference = 0.90, ES = 1.61, p = 0.003) and executive functioning (median difference = 0.97, ES = 1.24, p = 0.05). Memory recall was not significantly different between the two groups.ConclusionOlder non-demented individuals complaining of memory loss who walked &gt;4000 steps each day had thicker MTL sub-regions and better cognitive functioning than those who walked ≤4000 steps. Future studies should include longitudinal analyses and explore mechanisms mediating hippocampal related atrophy

Repeatability and Reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomography

Aim: To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes using the Topcon 3D OCT-1000. Methods: Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator, within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by 2 operators. Results: Phase 1: No significant difference existed between repeat scans (p=0.75) and no significant difference was found pre- and post-dilation (p=0.54). In the younger group variation was low (95% limits ± 3.62 m) and comparable across all retinal regions. The older group demonstrated greater variation (95% limits ± 7.6 m). Phase 2: For a given retinal location, 95% confidence limits for within-operator, within-visit reproducibility was 5.16 m. This value increased to 5.56 m for the same operator over two visits and to 6.18 m for two operators over two visits. Conclusion: A high level repeatability, close to 6 m, of macular thickness measurement is possible using the 3D OCT- 1000. Measured differences in macular thickness between successive visits that exceed 6 m in pre-presbyopic individuals are therefore likely to reflect actual structural change. OCT measures are more variable in older individuals and it is advisable to take a series of scans so that outliers can be more easily identified

Quantifying non-star formation associated 8um dust emission in NGC 628

Combining Ha and IRAC images of the nearby spiral galaxy NGC 628, we find that between 30-43% of its 8um dust emission is not related to recent star formation. Contributions from dust heated by young stars are separated by identifying HII regions in the Ha map and using these areas as a mask to determine the 8um dust emission that must be due to heating by older stars. Corrections are made for sub-detection-threshold HII regions, photons escaping from HII regions and for young stars not directly associated to HII regions (i.e. 10-100 Myr old stars). A simple model confirms this amount of 8um emission can be expected given dust and PAH absorption cross-sections, a realistic star-formation history, and the observed optical extinction values. A Fourier power spectrum analysis indicates that the 8um dust emission is more diffuse than the Ha emission (and similar to observed HI), supporting our analysis that much of the 8um-emitting dust is heated by older stars. The 8um dust-to-Ha emission ratio declines with galactocentric radius both within and outside of HII regions, probably due to a radial increase in disk transparency. In the course of this work, we have also found that intrinsic diffuse Ha fractions may be lower than previously thought in galaxies, if the differential extinction between HII regions and diffuse regions is taken into account.Comment: 14 pages, 11 figures, accepted in Ap

Queens Library HealthLink: Fighting Health Disparities through Community Engagement

Queens, New York is a diverse urban environment and home to many recent immigrants and low-income populations, which are known to have lower access to healthcare and are thus at higher risk for a wide range of negative health outcomes. Queens residents face serious cancer disparities, with late-stage cancer detection rates for breast, colorectal and prostate cancers far surpassing national averages. Developed to address such disparities, Queens Library HealthLink (HealthLink) is a four-way partnership that seeks to increase access to cancer screening, care and education in medically underserved neighborhoods in Queens. Through 20 of the 62 Queens Public Libraries, HealthLink organizes community members into Cancer Action Councils that develop and tailor interventions suited to community needs, assets and priorities, as well as perform evaluation of their work. This article describes the partnership, its program outcomes and case examples of successful initiatives in order to present HealthLink’s relevance to other urban public libraries as a model for reaching broad, underserved audiences with health information and services

Vision Screening Assessment (VISA) tool: diagnostic accuracy validation of a novel screening tool in detecting visual impairment among stroke survivors

PURPOSE:Screening for visual problems in stroke survivors is not standardised. Visual problems that remain undetected or poorly identified can create unmet needs for stroke survivors. We report the validation of a new Vision Impairment Screening Assessment (VISA) tool intended for use by the stroke team to improve identification of visual impairment in stroke survivors. METHODS:We conducted a prospective case cohort comparative study in four centres to validate the VISA tool against a specialist reference vision assessment. VISA is available in print or as an app (Medicines and Healthcare products Regulatory Agency regulatory approved); these were used equally for two groups. Both VISA and the comprehensive reference vision assessment measured case history, visual acuity, eye alignment, eye movements, visual field and visual inattention. The primary outcome measure was the presence or absence of visual impairment. RESULTS:Two hundred and twenty-one stroke survivors were screened. Specialist reference vision assessment was by experienced orthoptists. Full completion of screening and reference vision assessment was achieved for 201 stroke survivors. VISA print was completed for 101 stroke survivors; VISA app was completed for 100. Sensitivity and specificity of VISA print was 97.67% and 66.67%, respectively. Overall agreement was substantial; K=0.648. Sensitivity and specificity of VISA app was 88.31% and 86.96%, respectively. Overall agreement was substantial; K=0.690. Lowest agreement was found for screening of eye movement and near visual acuity. CONCLUSIONS:This validation study indicates acceptability of VISA for screening of potential visual impairment in stroke survivors. Sensitivity and specificity were high indicating the accuracy of this screening tool. VISA is available in print or as an app allowing versatile uptake across multiple stroke settings

Dosing regimen of meropenem for adults with severe burns : a population pharmacokinetic study with Monte Carlo simulations

Objectives To develop a population model to describe the pharmacokinetics (PK) of intravenous meropenem in adult patients with severe burns and investigate potential relationships between dosage regimens and antimicrobial efficacy.Patients and methods A dose of 1 g every 8 h was administered to adult patients with total body surface area burns of ≥15%. Doses for subsequent courses were determined using results from the initial course and the patient's clinical condition. Five plasma meropenem concentrations were typically measured over the dosage interval on one to four occasions. An open, two-compartment PK model was fitted to the meropenem concentrations using NONMEM and the effect of covariates on meropenem PK was investigated. Monte Carlo simulations investigated dosage regimens to achieve a target T>MIC for ≥40%, ≥60% or ≥80% of the dose interval.Results Data comprised 113 meropenem concentration measurements from 20 dosage intervals in 12 patients. The parameters were CL (L/h) = 0.196 L/h/kg × [1 − 0.023 × (age − 46)] × [1 − 0.049 × (albumin − 15)], V1 = 0.273 L/kg × [1 − 0.049 × (albumin − 15)], Q = 0.199 L/h/kg and V2 = 0.309 L/kg × [1 – 0.049 × (albumin − 15)]. For a target of ≥80% T>MIC, the breakpoint was 8 mg/L for doses of 1 g every 4 h and 2 g every 8 h given over 3 h, but only 4 mg/L if given over 5 min.Conclusions Although 1 g 8 hourly should be effective against Escherichia coli and CoNS, higher doses, ideally with a longer infusion time, would be more appropriate for empirical therapy, mixed infections and bacteria with MIC values ≥4 mg/L

Road space reallocation in Scotland: A health impact assessment

IntroductionRoad space reallocation involves re-distributing space away from motor vehicles, including car parking and carriageway space, towards other uses. This can promote a shift to more sustainable travel modes and is likely to affect health through multiple pathways.MethodsWe conducted a health impact assessment to identify and assess the potential impacts of road space reallocation on health and health inequalities in Scotland. This involved a facilitated scoping workshop to identify potential impacts, collation of routine data, interviews with 13 key informants and a rapid review of research literature.ResultsWe found that road space reallocation could have positive impacts on health by reducing overall levels of private motorised traffic, encouraging walking, wheeling and cycling, realising benefits from alternative uses of space and supporting local businesses. There is potential for positive impact on public transport if space is reallocated to prioritise buses, but bus users can also be disadvantaged if bus routes are diverted or stops impeded. Reallocation can improve transport and health equity if it increases support for modes other than car use, but disabled people may be disadvantaged if the reallocated space, and alternative modes, are not accessible for them.ConclusionsRoad space reallocation can improve health and help reduce health inequalities. However, consideration is needed to ensure sufficient alternatives to car use are supported and the reallocated space is accessible for people with different needs. Reallocation schemes should be considered as part of a wider inclusive approach to road transport supporting active travel and public or community transport. Road space reallocation should contribute to wider place-making initiatives aiming to improve quality of local environments and meet community needs