The Effectiveness and Perceptions of Three Moderate Intensity Walking Cadence Aids and their Effects on Affective States: A Mixed Methods Study

Substantial health benefits can be derived from walking at a moderate intensity cadence. To help regulate this cadence, three distinct aids exist 1) self-perception; 2) cadence prescription; 3) auditory cues. This study aimed to compare the effectiveness and explore perceptions of these aids to promote moderate intensity walking and effects on affective states, thereby addressing an important research gap. Individualised moderate relative intensity waking cadence was determined for participants (n = 23, = 26.35, SD = 10.11). A convergent mixed-methods design was employed. A within-persons repeated measures design was used to explore the effectiveness of three aids (general guidelines, cadence prescription, and music) on promoting moderate intensity physical activity and positive affective states. Perceptions of these aids were elicited through qualitative interviews and thematic content analysis. Main effects for condition on relative physical activity intensity (η = .72) and positive affect (η = .25) were observed. Music evoked significantly higher relative physical activity intensity than other conditions (p values < .01), and higher positive affect compared to the general guidelines condition (p = .038). A significantly greater proportion of participants achieved moderate relative intensity physical activity during the music compared to general guidelines condition (p = .03). Congruently, qualitative findings suggested that participants predominantly perceived music as most effective for promoting a moderate intensity cadence and positive affect. However, individual variability existed in ability to utilise this aid. Implications of the findings for practitioners seeking to promote a moderate intensity cadence and positive affect during walking are discussed

Advanced Composite Solar Sail System: Demonstrating Deployable Composite Solar Sails for Future Deep Space Small Spacecraft

NASA is developing new deployable structures and materials technologies for solar sail propulsion systems destined for future low-cost deep space missions. Solar sails eliminate the need for conventional rocket propellants, relying instead upon the pressure of sunlight to generate continuous thrust. They can operate indefinitely, limited only by the space environment durability of the solar sail materials and spacecraft electronic systems.At NASA's Langley Research Center in Hampton, Virginia, and NASA's Ames Research Center in California's Silicon Valley, researchers and engineers are planning a mission to demonstrate the next generation of solar sail technology for small interplanetary spacecraft. As part of this development effort, the Advanced Composite Solar Sail System (ACS3) will demonstrate deployment of an approximately 800 square foot (74 square meter) composite boom (mast) solar sail system in low-Earth orbit. This will be the first use of composite booms as well as sail packing and deployment systems for a solar sail in orbit

Enhanced deep-blue emission from Pt(II) complexes bound to 2-pyridyltetrazolate and an ortho-xylene-linked bis(NHC)cyclophane

The coordination of 2-pyridyltetrazolate and ortho-xylene-linked bis(NHC)cyclophane to Pt(II) yielded a novel complex characterised by enhanced pure deep-blue emission, whose intensity can be modulated via methylation of the tetrazole ring

Association between stressful life events and psychotic experiences in adolescence: evidence for gene-environment correlations

- Background: Stressful life events (SLEs) are associated with psychotic experiences (PEs). SLEs might act as an environmental risk factor, but may also share a genetic propensity with PEs. - Aims: Estimate the extent to which genetic and environmental factors influence the relationship between SLEs and PEs. - Method: Self and parent-reports from a community-based twin sample (4,830 16-year-old pairs) were analysed using structural equation model-fitting. - Results: SLEs correlated with positive PEs (r = .12-.14, all p<. 001). Modest heritability was shown for PEs (25-57%) and dependent SLEs (32%). Genetic influences explained the majority of the modest covariation between dependent SLEs and paranoia and cognitive disorganisation (bivariate heritabilities = 74-86%). The relationship between SLEs and hallucinations and grandiosity was explained by both genetic and common environmental effects. - Conclusion: Further to dependent SLEs being an environmental risk factor, individuals may have an underlying genetic propensity increasing their risk of dependent SLEs and positive PEs

Venezuela: Background and U.S. Relations

This report report provides an overview of the overlapping political, economic, and social crises in Venezuela, followed by an overview of U.S. policy toward Venezuela

The Effectiveness and Perceptions of Three Moderate Intensity Walking Cadence Aids and their Effects on Affective States: a Mixed Methods Study

Substantial health benefits can be derived from walking at a moderate intensity cadence. To help regulate this cadence three distinct aids exist 1) self-perception; 2) cadence prescription; 3) auditory cues. This study aimed to compare the effectiveness and explore perceptions of these aids to promote moderate intensity walking and effects on affective states, thereby addressing an important research gap. Individualised moderate relative intensity waking cadence was determined for participants (n = 23, Mage = 26.35, SD = 10.11). A convergent mixed-methods design was employed. A within-persons repeated measures design was used to explore the effectiveness of three aids (general guidelines, cadence prescription, and music) on promoting moderate intensity physical activity and positive affective states. Perceptions of these aids were elicited through qualitative interviews with thematic content analysis. Main effects for condition on relative physical activity intensity (η 2 = .72) and positive affect (η 2 = .25) were observed. Music evoked significantly higher relative physical activity intensity than other conditions (p values < .01), and higher positive affect compared to the general guidelines condition (p = .038). A significantly greater proportion of participants achieved moderate relative intensity physical activity during the music compared to general guidelines condition (p = .03). Congruently, qualitative findings suggested that participants predominantly perceived music as most effective for promoting a moderate intensity cadence and positive affect. However, individual variability existed in ability to utilise this aid. Implications of the findings for practitioners seeking to promote a moderate intensity cadence and positive affect during walking are discussed

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.

Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer–associated mortality. Recent gene expression profiling has proven successful in predicting the outcome of prostate cancer patients; however, they have yet to provide targeted therapy approaches that could inhibit a patient\u27s progression to metastatic disease. Experimental Design: We have interrogated a total of seven primary prostate cancer cohorts (n = 1,900), two metastatic castration-resistant prostate cancer datasets (n = 293), and one prospective cohort (n = 1,385) to assess the impact of TOP2A and EZH2 expression on prostate cancer cellular program and patient outcomes. We also performed IHC staining for TOP2A and EZH2 in a cohort of primary prostate cancer patients (n = 89) with known outcome. Finally, we explored the therapeutic potential of a combination therapy targeting both TOP2A and EZH2 using novel prostate cancer–derived murine cell lines. Results: We demonstrate by genome-wide analysis of independent primary and metastatic prostate cancer datasets that concurrent TOP2A and EZH2 mRNA and protein upregulation selected for a subgroup of primary and metastatic patients with more aggressive disease and notable overlap of genes involved in mitotic regulation. Importantly, TOP2A and EZH2 in prostate cancer cells act as key driving oncogenes, a fact highlighted by sensitivity to combination-targeted therapy. Conclusions: Overall, our data support further assessment of TOP2A and EZH2 as biomarkers for early identification of patients with increased metastatic potential that may benefit from adjuvant or neoadjuvant targeted therapy approaches. ©2017 AACR

Modeling the magnetic field in the galactic disk using new rotation measure observations from the Very Large Array

We have determined 194 Faraday rotation measures (RMs) of polarized extragalactic radio sources using new, multi-channel polarization observations at frequencies around 1.4 GHz from the Very Large Array (VLA) in the Galactic plane at 17◦ ≤ l ≤ 63◦ and 205◦ ≤ l ≤ 253◦. This catalog fills in gaps in the RM coverage of the Galactic plane between the Canadian Galactic Plane Survey and Southern Galactic Plane Survey. Using this catalog we have tested the validity of recently-proposed axisymmetric and bisymmetric models of the largescale (or regular) Galactic magnetic field, and found that of the existing models we tested, an axisymmetric spiral model with reversals occurring in rings (as opposed to along spiral arms) best matched our observations. Building on this, we have performed our own modeling, using RMs from both extragalactic sources and pulsars. By developing independent models for the magnetic field in the outer and inner Galaxy, we conclude that in the inner Galaxy, the magnetic field closely follows the spiral arms, while in the outer Galaxy, the field is consistent with being purely azimuthal. Furthermore, the models contain no reversals in the outer Galaxy, and together seem to suggest the existence of a single reversed region that spirals out from the Galactic cente