1,949 research outputs found
Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency
Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis. Our aim was to assess how maternal and offspring fatty acid metabolism is altered in mothers in the third trimester of pregnancy with PE (n=62) or intrauterine growth restriction (n=23) compared with healthy pregnancies (n=164). Markers of lipid metabolism and erythrocyte fatty acid concentrations were measured. Maternal adipose tissue fatty acid composition and mRNA expression of adipose tissue fatty acidâmetabolizing enzymes and placental fatty acid transporters were compared. Mothers with PE had higher plasma triglyceride (21%, P<0.001) and nonesterified fatty acid (50%, P<0.001) concentrations than controls. Concentrations of major nâ6 and nâ3 long-chain polyunsaturated fatty acids in erythrocytes were 23% to 60% lower (all P<0.005) in PE and intrauterine growth restriction mothers and offspring compared with controls. Subcutaneous adipose tissue Îâ5 and Îâ6 desaturase and very long-chain fatty acid elongase mRNA expression was lower in PE than controls (respectively, mean [SD] control 3.38 [2.96] versus PE 1.83 [1.91], P=0.030; 3.33 [2.25] versus 1.03 [0.96], P<0.001; 0.40 [0.81] versus 0.00 [0.00], P=0.038 expression relative to control gene [square root]). Low maternal and fetal long-chain polyunsaturated fatty acid concentrations in PE may be the result of decreased maternal synthesis
Proton-Rich Nuclear Statistical Equilibrium
Proton-rich material in a state of nuclear statistical equilibrium (NSE) is
one of the least studied regimes of nucleosynthesis. One reason for this is
that after hydrogen burning, stellar evolution proceeds at conditions of equal
number of neutrons and protons or at a slight degree of neutron-richness.
Proton-rich nucleosynthesis in stars tends to occur only when hydrogen-rich
material that accretes onto a white dwarf or neutron star explodes, or when
neutrino interactions in the winds from a nascent proto-neutron star or
collapsar-disk drive the matter proton-rich prior to or during the
nucleosynthesis. In this paper we solve the NSE equations for a range of
proton-rich thermodynamic conditions. We show that cold proton-rich NSE is
qualitatively different from neutron-rich NSE. Instead of being dominated by
the Fe-peak nuclei with the largest binding energy per nucleon that have a
proton to nucleon ratio close to the prescribed electron fraction, NSE for
proton-rich material near freeze-out temperature is mainly composed of Ni56 and
free protons. Previous results of nuclear reaction network calculations rely on
this non-intuitive high proton abundance, which this paper will explain. We
show how the differences and especially the large fraction of free protons
arises from the minimization of the free energy as a result of a delicate
competition between the entropy and the nuclear binding energy.Comment: 4 pages, 7 figure
'20 days protected learning' - students' experiences of an Overseas Nurses Programme - 4 years on: A retrospective survey
Background
From September 2005 the Nursing and Midwifery Council (NMC) introduced new arrangements for the registration of non-EU overseas nurses which requires all applicants to undertake '20 days of protected learning' time in the UK and for some, a period of supervised practice. A survey was undertaken at Bournemouth University, which offers a '20 days protected learning only' programme, to elicit overseas nurses' demographic details, experiences in completing the programme and their 'final destinations' once registered.
Methods
An online survey was devised which contained a mixture of tick box and open ended questions which covered demographic details, views on the programme and final destinations This was uploaded to www.SurveyMonkey.com and sent out to nurses who had completed the Overseas Nurses Programme (ONP) with Bournemouth University (n=1050). Quantiative data were analysed using descriptive statistics and the qualitative data were coded and analysed using content analysis .
Results
There were 251 respondents (27.7% response rate). The typical 'profile' of a nurse who responded to the survey was female, aged 25-40 years and had been qualified for more than 5 years with a bachelors degree. The majority came from Australia on a 2 year working holiday visa and the key final destination in the UK, on registration with the NMC, was working for an agency. There were five key findings regarding experience of the programe. Of those surveyed 61.2% did not feel it necessary to undergo an ONP; 71.6% felt that they should be able to complete the programme on-line in their own country; 64.2% that the ONP should only contain information about delivery of healthcare in UK and Legal and professional (NMC) issues; 57% that European nurses should also undergo the same programme and sit an IELTS test; and 68.2% that the programme was too theory orientated; and should have links to practice (21%).
Conclusions
The NMC set the admissions criteria for entry to the register and Standards for an ONP. The findings of this survey raise issues regarding the percieved value and use of this approach for overseas nurses, and it may be helpful to take this into account when considering future policy
Discovering the Data of Safety: Embry-Riddleâs Aviation Safety and Security Archives
The path to the sky and beyond has not been simple or obstacle-free, but dedicated dreamers have worked to overcome obstacles, learn from mishaps, and develop new technologies to achieve their goals. As the leading university for aviation and aerospace education, Embry-Riddle Aeronautical University maintains a firm commitment to the practice and study of safety. As part of this mission, the university has established the Aviation Safety and Security Archives (ASASA) which is a national treasure of aviation safety history and information
Quantum Simulation of Tunneling in Small Systems
A number of quantum algorithms have been performed on small quantum
computers; these include Shor's prime factorization algorithm, error
correction, Grover's search algorithm and a number of analog and digital
quantum simulations. Because of the number of gates and qubits necessary,
however, digital quantum particle simulations remain untested. A contributing
factor to the system size required is the number of ancillary qubits needed to
implement matrix exponentials of the potential operator. Here, we show that a
set of tunneling problems may be investigated with no ancillary qubits and a
cost of one single-qubit operator per time step for the potential evolution. We
show that physically interesting simulations of tunneling using 2 qubits (i.e.
on 4 lattice point grids) may be performed with 40 single and two-qubit gates.
Approximately 70 to 140 gates are needed to see interesting tunneling dynamics
in three-qubit (8 lattice point) simulations.Comment: 4 pages, 2 figure
Nucleosynthesis in thermonuclear supernovae with tracers: convergence and variable mass particles
Nucleosynthetic yield predictions for multi-dimensional simulations of
thermonuclear supernovae generally rely on the tracer particle method to obtain
isotopic information of the ejected material for a given supernova simulation.
We investigate how many tracer particles are required to determine converged
integrated total nucleosynthetic yields. For this purpose, we conduct a
resolution study in the number of tracer particles for different hydrodynamical
explosion models at fixed spatial resolution. We perform hydrodynamic
simulations on a co-expanding Eulerian grid in two dimensions assuming
rotational symmetry for both pure deflagration and delayed detonation Type Ia
supernova explosions. Within a given explosion model, we vary the number of
tracer particles to determine the minimum needed for the method to give a
robust prediction of the integrated yields of the most abundant nuclides. For
the first time, we relax the usual assumption of constant tracer particle mass
and introduce a radially vary- ing distribution of tracer particle masses. We
find that the nucleosynthetic yields of the most abundant species (mass
fraction > 10E-5) are reasonably well predicted for a tracer number as small as
32 per axis and direction - more or less independent of the explosion model. We
conclude that the number of tracer particles that were used in extant published
works appear to have been sufficient as far as integrated yields are concerned
for the most copiously produced nuclides. Additionally we find that a suitably
chosen tracer mass distribution can improve convergence for nuclei produced in
the outer layer of the supernova where the constant tracer mass prescription
suffers from poor spatial resolution.Comment: 9 pages, 5 figures, accepted for publication in MNRA
Simultaneous EEG-fMRI Reveals Temporal Evolution of Coupling between Supramodal Cortical Attention Networks and the Brainstem
Cortical and subcortical networks have been identified that are commonly associated with attention and task engagement, along with theories regarding their functional interaction. However, a link between these systems has not yet been demonstrated in healthy humans, primarily because of data acquisition and analysis limitations. We recorded simultaneous EEGâfMRI while subjects performed auditory and visual oddball tasks and used these data to investigate the BOLD correlates of single-trial EEG variability at latencies spanning the trial. We focused on variability along task-relevant dimensions in the EEG for identical stimuli and then combined auditory and visual data at the subject level to spatially and temporally localize brain regions involved in endogenous attentional modulations. Specifically, we found that anterior cingulate cortex (ACC) correlates strongly with both early and late EEG components, whereas brainstem, right middle frontal gyrus (rMFG), and right orbitofrontal cortex (rOFC) correlate significantly only with late components. By orthogonalizing with respect to event-related activity, we found that variability in insula and temporoparietal junction is reflected in reaction time variability, rOFC and brainstem correlate with residual EEG variability, and ACC and rMFG are significantly correlated with both. To investigate interactions between these correlates of temporally specific EEG variability, we performed dynamic causal modeling (DCM) on the fMRI data. We found strong evidence for reciprocal effective connections between the brainstem and cortical regions. Our results support the adaptive gain theory of locus ceruleusânorepinephrine (LCâNE) function and the proposed functional relationship between the LCâNE system, right-hemisphere ventral attention network, and P300 EEG response
Tomographic Separation of Composite Spectra. VIII. The Physical Properties of the Massive Compact Binary in the Triple Star System HD 36486 (delta Orionis A)
Double-lined spectroscopic orbital elements have recently been found for the
central binary in the massive triple, delta Orionis A based on radial
velocities from cross-correlation techniques applied to IUE high dispersion
spectra and He I 6678 spectra obtained at Kitt Peak. The primary and secondary
velocity amplitudes were found to be 94.9 +/- 0.6 km/s and 186 +/- 9 km/s
respectively. Tomographic reconstructions of the primary and secondary stars'
spectra confirm the O9.5 II classification of the primary and indicate a B0.5
III type for the secondary. The widths of the UV cross-correlation functions
are used to estimate the projected rotational velocities, Vsin i = 157 +/- 6
km/s and 138 +/- 16 km/s for the primary and secondary, respectively implying
that both stars rotate faster than their orbital motion. We used the
spectroscopic results to make a constrained fit of the Hipparcos light curve of
this eclipsing binary, and the model fits limit the inclination to the range
between 67 and 77 degrees. The i = 67 degrees solution, which corresponds to a
near Roche-filling configuration, results in a primary mass of 11.2 solar
masses and a secondary mass of 5.6 solar masses, both of which are
substantially below the expected masses for stars of their luminosity. This
binary may have experienced a mass ratio reversal caused by Case A Roche lobe
overflow, or the system may have suffered extensive mass loss through a binary
interaction, perhaps during a common envelope phase, in which most of the
primary's mass was lost from the system rather than transferred to the
secondary.Comment: 27 pages, 15 figures in press, the Astrophysical Journal, February 1,
200
Linear Response, Validity of Semi-Classical Gravity, and the Stability of Flat Space
A quantitative test for the validity of the semi-classical approximation in
gravity is given. The criterion proposed is that solutions to the
semi-classical Einstein equations should be stable to linearized perturbations,
in the sense that no gauge invariant perturbation should become unbounded in
time. A self-consistent linear response analysis of these perturbations, based
upon an invariant effective action principle, necessarily involves metric
fluctuations about the mean semi-classical geometry, and brings in the
two-point correlation function of the quantum energy-momentum tensor in a
natural way. This linear response equation contains no state dependent
divergences and requires no new renormalization counterterms beyond those
required in the leading order semi-classical approximation. The general linear
response criterion is applied to the specific example of a scalar field with
arbitrary mass and curvature coupling in the vacuum state of Minkowski
spacetime. The spectral representation of the vacuum polarization function is
computed in n dimensional Minkowski spacetime, and used to show that the flat
space solution to the semi-classical Einstein equations for n=4 is stable to
all perturbations on distance scales much larger than the Planck length.Comment: 22 pages: This is a significantly expanded version of gr-qc/0204083,
with two additional sections and two new appendices giving a complete,
explicit example of the semi-classical stability criterion proposed in the
previous pape
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