The Hebraic Monarchy as God’s Redemptive Response to Israel’s Unfaithfulness

The first portion of this paper will argue that the Old Testament portrays the monarchy neither as God’s chosen method of relating to his people, nor as an intrinsically evil institution, but as God’s redemptive response to Israel’s unfaithfulness. The second portion addresses a potential objection to this portrayal by arguing that Moses serves primarily as a type for Samuel, not the monarchy

A Review of John Rists\u27 Augustine on Free Will and Predestination

In this paper I seek to summarize and critique John Rist’s article “Augustine on Free Will and Predestination.” Rist treats Augustine with honesty. When someone is as prominent, loved, and recognized as Augustine, when someone has as much authority as he does, the temptation to manipulate his writings into saying things which agree with one’s own position is strong. Rist resists this temptation, even concluding that Augustine holds a position on free will and predestination which Rist finds highly objectionable. But in his objections to Augustine’s position, Rist does not do justice to the whole system of Augustine’s thought. In my critique I will focus on two points where Rist takes issue with Augustine: 1) Augustine’s lack of an account of how God acts justly in election and 2) the demeaning of man to the level of a “puppet.” I will attempt to demonstrate that Rist’s criticisms are accounted for by extending Augustine’s teachings of, regarding 1), causality and the will and, in regard to 2), the solidarity of humanity with Adam. The aim of this paper is not to prove that Augustine’s articulation of free will and God’s predestination is the correct one but only that his position can withstand the criticisms Rist brings against it

Race and Christian Interpersonal Relationships

Unfortunately no one seems to have a workable and effective plan to resolve societal racial tension that continues to exist in America and in the rest of the world. However, the Bible gives clear instructions as how to resolve racial conflicts. Having grown up in Hawaii, Caleb Brown shares his experiences about racial differences in that state and proposes biblical solutions to all interpersonal conflicts

Differentiating Averroes’ Accounts of the Metaphysics of Human Epistemology in his Middle and Long Commentaries on Aristotle’s De Anima

Averroes (an Islamic Andalusian philosopher in the 12th century) discusses the metaphysics of human epistemology extensively, and his socio-religious context sheds light on this discussion. Several of his works, most prominently his three commentaries on Aristotle’s De Anima, attempt to explain how finite, particular minds interact with universal, eternal intelligibles. Current scholarship focuses on the two longer commentaries, the Middle Commentary and the Long Commentary, but there is no consensus regarding which of these presents Averroes’ final articulation of the metaphysics of human epistemology. Those who maintain that Averroes wrote the Middle Commentary last tend to minimize the differences between the two accounts. This paper does not take a position on the chronology of Averroes’ works. Rather, it seeks to demonstrate that, even if Averroes wrote the Middle Commentary last, in light of Averroes’ socio-political environment, it is evident that the accounts of the metaphysics of human epistemology in the Middle and Long commentaries differ substantively

Effect of drying and/or warming piglets at birth on rectal temperature over the first 24 h after birth

Piglets experience a rapid decrease in body temperature immediately after birth, increasing the risk of mortality. The objective of this study was to determine the effect of drying and/or warming piglets at birth on rectal temperature over the first 24 h after birth. The study was carried out at a commercial sow facility using a completely randomized design with four treatments (applied to piglets at birth): Control (no drying or warming), Desiccant (dried using a desiccant), Warming Box (placed in a box under a heat lamp for 30 min), and Desiccant + Warming Box (both dried and warmed as above). Farrowing pens had one heat lamp, temperatures under which were similar to the warming box (35 °C). A total of 68 litters (866 piglets) were randomly allotted to a treatment at the birth of the first piglet. At birth, each piglet was identified with a numbered ear tag and weighed; rectal temperature was measured at 0, 10, 20, 30, 45, 60, 120, and 1,440 min after birth. Data were analyzed using a repeated-measures model using PROC MIXED of SAS. Litter was the experimental unit, piglet was a subsample of the litter; and the model included the fixed effects of treatment, time (the repeated measure), and the interaction. Rectal temperatures at birth and 1,440 min after birth were similar (P \u3e 0.05) for all treatments. At all times between 10 and 120 min after birth, Control piglets had lower (P ≤ 0.05) temperatures than the other three treatments. The Desiccant and Warming Box treatments had similar (P \u3e 0.05) temperatures at most measurement times, but the Desiccant + Warming Box treatment had the highest (P ≤ 0.05) rectal temperatures at most times between 10 and 60 min. In addition, for all treatments, light (\u3c1.0 kg) birth weight piglets had lower (P ≤ 0.05) temperatures than medium (1.0–1.5 kg) or heavy (\u3e1.5 kg) piglets at all times between 10 and 120 min. In addition, at these measurement times, the deviation in temperature between the Control and the other three treatments was greater for light than medium or heavy piglets. In conclusion, both drying and warming piglets at birth significantly increased rectal temperatures between 10 and 120 min after birth, with the combination of the two interventions having the greatest effect, especially for low birth weight piglets

Iron catalysed Negishi cross-coupling using simple ethyl-monophosphines

Reported is a rare example of the use of monophosphines in iron catalysed Negishi cross-coupling. Substrate scope in terms of alkyl bromide and diaryl zinc reagent is explored.</p

Reducing Decisional Conflict and Enhancing Satisfaction with Information among Women Considering Breast Reconstruction following Mastectomy: Results from the BRECONDA Randomized Controlled Trial

Background: Deciding whether or not to have breast reconstruction following breast cancer diagnosis is a complex decision process. This randomized controlled trial assessed the impact of an online decision aid [Breast RECONstruction Decision Aid (BRECONDA)] on breast reconstruction decision-making. Methods: Women (n = 222) diagnosed with breast cancer or ductal carcinoma in situ, and eligible for reconstruction following mastectomy, completed an online baseline questionnaire. They were then assigned randomly to receive either standard online information about breast reconstruction (control) or standard information plus access to BRECONDA (intervention). Participants then completed questionnaires at 1 and 6 months after randomization. The primary outcome was participants' decisional conflict 1 month after exposure to the intervention. Secondary outcomes included decisional conflict at 6 months, satisfaction with information at 1 and 6 months, and 6-month decisional regret. Results: Linear mixed-model analyses revealed that 1-month decisional conflict was significantly lower in the intervention group (27.18) compared with the control group (35.5). This difference was also sustained at the 6-month follow-up. Intervention participants reported greater satisfaction with information at 1- and 6-month follow-up, and there was a nonsignificant trend for lower decisional regret in the intervention group at 6-month follow-up. Intervention participants' ratings for BRECONDA demonstrated high user acceptability and overall satisfaction. Conclusions: Women who accessed BRECONDA benefited by experiencing significantly less decisional conflict and being more satisfied with information regarding the reconstruction decisional process than women receiving standard care alone. These findings support the efficacy of BRECONDA in helping women to arrive at their breast reconstruction decision

A unified framework for the orbital structure of bars and triaxial ellipsoids

We examine a large random sample of orbits in two self-consistent simulations of N-body bars. Orbits in these bars are classified both visually and with a new automated orbit classification method based on frequency analysis. The well-known prograde x1 orbit family originates from the same parent orbit as the box orbits in stationary and rotating triaxial ellipsoids. However, only a small fraction of bar orbits (~4%) have predominately prograde motion like their periodic parent orbit. Most bar orbits arising from the x1 orbit have little net angular momentum in the bar frame, making them equivalent to box orbits in rotating triaxial potentials. In these simulations a small fraction of bar orbits (~7%) are long-axis tubes that behave exactly like those in triaxial ellipsoids: they are tipped about the intermediate axis owing to the Coriolis force, with the sense of tipping determined by the sign of their angular momentum about the long axis. No orbits parented by prograde periodic x2 orbits are found in the pure bar model, but a tiny population (~2%) of short-axis tube orbits parented by retrograde x4 orbits are found. When a central point mass representing a supermassive black hole (SMBH) is grown adiabatically at the center of the bar, those orbits that lie in the immediate vicinity of the SMBH are transformed into precessing Keplerian orbits that belong to the same major families (short-axis tubes, long-axis tubes and boxes) occupying the bar at larger radii. During the growth of an SMBH, the inflow of mass and outward transport of angular momentum transform some x1 and long-axis tube orbits into prograde short-axis tubes. This study has important implications for future attempts to constrain the masses of SMBHs in barred galaxies using orbit-based methods like the Schwarzschild orbit superposition scheme and for understanding the observed features in barred galaxies

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance. We previously identified a subset of doxorubicin-resistant cells in human angiosarcoma and canine hemangiosarcoma cell lines that exhibit high lysosomal accumulation of doxorubicin. Hydrophobic, weak base chemotherapeutics, like doxorubicin, are known to sequester within lysosomes, promoting resistance by limiting drug accessibility to cellular targets. Drug synergy between the beta adrenergic receptor (β-AR) antagonist, propranolol, and multiple chemotherapeutics has been documented in vitro, and clinical data have corroborated the increased therapeutic potential of propranolol with chemotherapy in angiosarcoma patients. Because propranolol is also a weak base and accumulates in lysosomes, we sought to determine whether propranolol enhanced doxorubicin cytotoxicity via antagonism of β-ARs or by preventing the lysosomal accumulation of doxorubicin. β-AR-like immunoreactivities were confirmed in primary tumor tissues and cell lines; receptor function was verified by monitoring downstream signaling pathways of β-ARs in response to receptor agonists and antagonists. Mechanistically, propranolol increased cytoplasmic doxorubicin concentrations in sarcoma cells by decreasing the lysosomal accumulation and cellular efflux of this chemotherapeutic agent. Equivalent concentrations of the receptor-active S-(−) and -inactive R-(+) enantiomers of propranolol produced similar effects, supporting a β-AR-independent mechanism. Long-term exposure of hemangiosarcoma cells to propranolol expanded both lysosomal size and number, yet cells remained sensitive to doxorubicin in the presence of propranolol. In contrast, removal of propranolol increased cellular resistance to doxorubicin, underscoring lysosomal doxorubicin sequestration as a key mechanism of resistance. Our results support the repurposing of the R-(+) enantiomer of propranolol with weak base chemotherapeutics to increase cytotoxicity and reduce the development of drug-resistant cell populations without the cardiovascular and other side effects associated with antagonism of β-ARs