Microcanonical statistics of black holes and bootstrap condition

The microcanonical statistics of the Schwarzschild black holes as well as the Reissner-Nordstr$\sf \ddot{o}$m black holes are analyzed. In both cases we set up the inequalities in the microcanonical density of states. These are then used to show that the most probable configuration in the gases of black holes is that one black hole acquires all of the mass and all of the charge at high energy limit. Thus the black holes obey the statistical bootstrap condition and, in contrast to the other investigation, we see that U(1) charge does not break the bootstrap property.Comment: 16 pages. late

Topology Change in Canonical Quantum Cosmology

We develop the canonical quantization of a midisuperspace model which contains, as a subspace, a minisuperspace constituted of a Friedman-Lema\^{\i}tre-Robertson-Walker Universe filled with homogeneous scalar and dust fields, where the sign of the intrinsic curvature of the spacelike hypersurfaces of homogeneity is not specified, allowing the study of topology change in these hypersurfaces. We solve the Wheeler-DeWitt equation of the midisuperspace model restricted to this minisuperspace subspace in the semi-classical approximation. Adopting the conditional probability interpretation, we find that some of the solutions present change of topology of the homogeneous hypersurfaces. However, this result depends crucially on the interpretation we adopt: using the usual probabilistic interpretation, we find selection rules which forbid some of these topology changes.Comment: 23 pages, LaTex file. We added in the conclusion some comments about path integral formalism and corrected litle misprinting

Quantum Scalar Field on the Massless (2+1)-Dimensional Black Hole Background

The behavior of a quantum scalar field is studied in the metric ground state of the (2+1)-dimensional black hole of Ba\~nados, Teitelboim and Zanelli which contains a naked singularity. The one-loop BTZ partition function and the associate black hole effective entropy, the expectation value of the quantum fluctuation as well as the renormalized expectation value of the stress tensor are explicitly computed in the framework of the $\zeta$-function procedure. This is done for all values of the coupling with the curvature, the mass of the field and the temperature of the quantum state. In the massless conformally coupled case, the found stress tensor is used for determining the quantum back reaction on the metric due to the scalar field in the quantum vacuum state, by solving the semiclassical Einstein equations. It is finally argued that, within the framework of the 1/N expansion, the Cosmic Censorship Hypothesis is implemented since the naked singularity of the ground state metric is shielded by an event horizon created by the back reaction.Comment: 18 pages, RevTeX, no figures, minor changes, final version accepted for publication in Phys. Rev.

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities

PMCID: PMC3613350This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Intracellular Vesicles as Reproduction Elements in Cell Wall-Deficient L-Form Bacteria

Cell wall-deficient bacteria, or L-forms, represent an extreme example of bacterial plasticity. Stable L-forms can multiply and propagate indefinitely in the absence of a cell wall. Data presented here are consistent with the model that intracellular vesicles in Listeria monocytogenes L-form cells represent the actual viable reproductive elements. First, small intracellular vesicles are formed along the mother cell cytoplasmic membrane, originating from local phospholipid accumulation. During growth, daughter vesicles incorporate a small volume of the cellular cytoplasm, and accumulate within volume-expanding mother cells. Confocal Raman microspectroscopy demonstrated the presence of nucleic acids and proteins in all intracellular vesicles, but only a fraction of which reveals metabolic activity. Following collapse of the mother cell and release of the daughter vesicles, they can establish their own membrane potential required for respiratory and metabolic processes. Premature depolarization of the surrounding membrane promotes activation of daughter cell metabolism prior to release. Based on genome resequencing of L-forms and comparison to the parental strain, we found no evidence for predisposing mutations that might be required for L-form transition. Further investigations revealed that propagation by intracellular budding not only occurs in Listeria species, but also in L-form cells generated from different Enterococcus species. From a more general viewpoint, this type of multiplication mechanism seems reminiscent of the physicochemical self-reproducing properties of abiotic lipid vesicles used to study the primordial reproduction pathways of putative prokaryotic precursor cells

Jellyfish Modulate Bacterial Dynamic and Community Structure

Jellyfish blooms have increased in coastal areas around the world and the outbreaks have become longer and more frequent over the past few decades. The Mediterranean Sea is among the heavily affected regions and the common bloom - forming taxa are scyphozoans Aurelia aurita s.l., Pelagia noctiluca, and Rhizostoma pulmo. Jellyfish have few natural predators, therefore their carcasses at the termination of a bloom represent an organic-rich substrate that supports rapid bacterial growth, and may have a large impact on the surrounding environment. The focus of this study was to explore whether jellyfish substrate have an impact on bacterial community phylotype selection. We conducted in situ jellyfish - enrichment experiment with three different jellyfish species. Bacterial dynamic together with nutrients were monitored to assess decaying jellyfish-bacteria dynamics. Our results show that jellyfish biomass is characterized by protein rich organic matter, which is highly bioavailable to ‘jellyfish - associated’ and ‘free - living’ bacteria, and triggers rapid shifts in bacterial population dynamics and composition. Based on 16S rRNA clone libraries and denaturing gradient gel electrophoresis (DGGE) analysis, we observed a rapid shift in community composition from unculturable Alphaproteobacteria to culturable species of Gammaproteobacteria and Flavobacteria. The results of sequence analyses of bacterial isolates and of total bacterial community determined by culture independent genetic analysis showed the dominance of the Pseudoalteromonadaceae and the Vibrionaceae families. Elevated levels of dissolved proteins, dissolved organic and inorganic nutrient release, bacterial abundance and carbon production as well as ammonium concentrations characterized the degradation process. The biochemical composition of jellyfish species may influence changes in the amount of accumulated dissolved organic and inorganic nutrients. Our results can contribute insights into possible changes in bacterial population dynamics and nutrient pathways following jellyfish blooms which have important implications for ecology of coastal waters

Candidate Glutamatergic Neurons in the Visual System of Drosophila

The visual system of Drosophila contains approximately 60,000 neurons that are organized in parallel, retinotopically arranged columns. A large number of these neurons have been characterized in great anatomical detail. However, studies providing direct evidence for synaptic signaling and the neurotransmitter used by individual neurons are relatively sparse. Here we present a first layout of neurons in the Drosophila visual system that likely release glutamate as their major neurotransmitter. We identified 33 different types of neurons of the lamina, medulla, lobula and lobula plate. Based on the previous Golgi-staining analysis, the identified neurons are further classified into 16 major subgroups representing lamina monopolar (L), transmedullary (Tm), transmedullary Y (TmY), Y, medulla intrinsic (Mi, Mt, Pm, Dm, Mi Am), bushy T (T), translobula plate (Tlp), lobula intrinsic (Lcn, Lt, Li), lobula plate tangential (LPTCs) and lobula plate intrinsic (LPi) cell types. In addition, we found 11 cell types that were not described by the previous Golgi analysis. This classification of candidate glutamatergic neurons fosters the future neurogenetic dissection of information processing in circuits of the fly visual system

The ADMORPH approach for Adaptively Morphing Embedded Systems

peer reviewedDue to the increasing performance demands of missionand safety-critical Cyber-Physical Systems (of Systems), these systems exhibit a rapidly growing complexity, manifested by an increasing number of (distributed) computational cores and application components connected via complex networks. However, with these systems’ growing complexity and interconnectivity, the chances of hardware failures and disruptions due to cyber-attacks will also quickly increase. In the ADMORPH project we explore system adaptivity, in terms of dynamically remapping application components to processing cores, to fuse fault- and intrusion tolerance with the increasing performance requirements of mission- and safety-critical CPS(oS). This paper describes the overall ADMORPH architecture and provides an overview of the developed methodologies, methods and tools for the specification, design, analysis and runtime deployment of adaptive mission- and safetycritical CPS(oS) that are robust against both component failures and cyber-attacks