538 research outputs found
Nimesulide in painful OA of the knee
Summary Objective:  This study was designed to investigate the analgesic effects of nimesulide and celecoxib in patients with knee osteoarthritis (OA). In patients with joint effusion, the effects of these non-steroidal anti-inflammatory drugs (NSAIDs) on synovial fluid concentrations of substance P (SP), interleukin (IL)-6 and IL-8 also were evaluated. Methods:  Patients were randomly assigned either nimesulide (100 mg twice a day) or celecoxib (200 mg once a day) for 2 weeks. The intensity of joint pain was assessed with a 100-mm visual analogue scale (VAS). Furthermore, patients completed questions about analgesic efficacy and overall tolerability of the treatments on a five-point categorial scale. Synovial fluid samples were drawn at baseline, 30 min after the first drug intake (day 1), and 30 min after the last drug intake (day 14). Results:  We enrolled 44 patients, 20 of whom had a joint effusion. In this group, the effects of nimesulide were more marked than for celecoxib, with evidence of a faster onset of the analgesic action. Both after a single or repeated administration, nimesulide significantly reduced the synovial fluid concentrations of SP and IL-6. Celecoxib, on the other hand, did not change the concentrations of SP and significantly reduced the levels of IL-6 only on day 14. None of the drugs affected IL-8. Both drugs were generally well tolerated. Conclusions:  These results provide evidence that nimesulide is an effective agent for the symptomatic treatment of OA. The effect on inflammatory pain mediators is consistent with the fast analgesic action of this NSAID
Sub MeV Particles Detection and Identification in the MUNU detector ((1)ISN, IN2P3/CNRS-UJF, Grenoble, France, (2)Institut de Physique, Neuch\^atel, Switzerland, (3) INFN, Padova Italy, (4) Physik-Institut, Z\"{u}rich, Switzerland)
We report on the performance of a 1 m TPC filled with CF at 3
bar, immersed in liquid scintillator and viewed by photomultipliers. Particle
detection, event identification and localization achieved by measuring both the
current signal and the scintillation light are presented. Particular features
of particle detection are also discussed. Finally, the Mn
photopeak, reconstructed from the Compton scattering and recoil angle is shown.Comment: Latex, 19 pages, 20 figure
A new FSA approach for in situ -ray spectroscopy
An increasing demand of environmental radioactivity monitoring comes both
from the scientific community and from the society. This requires accurate,
reliable and fast response preferably from portable radiation detectors. Thanks
to recent improvements in the technology, -spectroscopy with sodium
iodide scintillators has been proved to be an excellent tool for in-situ
measurements for the identification and quantitative determination of
-ray emitting radioisotopes, reducing time and costs. Both for
geological and civil purposes not only K, U, and Th have
to be measured, but there is also a growing interest to determine the
abundances of anthropic elements, like Cs and I, which are used
to monitor the effect of nuclear accidents or other human activities.
The Full Spectrum Analysis (FSA) approach has been chosen to analyze the
-spectra. The Non Negative Least Square (NNLS) and the energy
calibration adjustment have been implemented in this method for the first time
in order to correct the intrinsic problem related with the
minimization which could lead to artifacts and non physical results in the
analysis.
A new calibration procedure has been developed for the FSA method by using in
situ -spectra instead of calibration pad spectra. Finally, the new
method has been validated by acquiring -spectra with a 10.16 cm x 10.16
cm sodium iodide detector in 80 different sites in the Ombrone basin, in
Tuscany. The results from the FSA method have been compared with the laboratory
measurements by using HPGe detectors on soil samples collected in the different
sites, showing a satisfactory agreement between them. In particular, the
Cs isotopes has been implemented in the analysis since it has been
found not negligible during the in-situ measurements.Comment: accepted by Science of Total Environment: 8 pages, 10 figures, 3
table
First Measurement of the He3+He3-->He4+2p Cross Section down to the Lower Edge of the Solar Gamow Peak
We give the LUNA results on the cross section measurement of a key reaction
of the proton-proton chain strongly affecting the calculated neutrino
luminosity from the Sun: He3+He3-->He4+2p. Due to the cosmic ray suppression
provided by the Gran Sasso underground laboratory it has been possible to
measure the cross section down to the lower edge of the solar Gamow peak, i.e.
as low as 16.5 keV centre of mass energy. The data clearly show the cross
section increase due to the electron screening effect but they do not exhibit
any evidence for a narrow resonance suggested to explain the observed solar
neutrino flux.Comment: 5 pages, RevTeX, and 2 figures in PostScript Submitted for
publicatio
A new study of Mg(,n)Si angular distributions at = 3 - 5 MeV
The observation of Al gives us the proof of active nucleosynthesis in
the Milky Way. However the identification of the main producers of Al is
still a matter of debate. Many sites have been proposed, but our poor knowledge
of the nuclear processes involved introduces high uncertainties. In particular,
the limited accuracy on the Mg(,n)Si reaction cross
section has been identified as the main source of nuclear uncertainty in the
production of Al in C/Ne explosive burning in massive stars, which has
been suggested to be the main source of Al in the Galaxy. We studied
this reaction through neutron spectroscopy at the CN Van de Graaff accelerator
of the Legnaro National Laboratories. Thanks to this technique we are able to
discriminate the (,n) events from possible contamination arising from
parasitic reactions. In particular, we measured the neutron angular
distributions at 5 different beam energies (between 3 and 5 MeV) in the
\ang{17.5}-\ang{106} laboratory system angular range. The presented results
disagree with the assumptions introduced in the analysis of a previous
experiment.Comment: 9 pages, 9 figures - accepted by EPJ
Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents
Identification of serine/threonine kinase and nucleotide-binding site–leucine-rich repeat (NBS-LRR) genes in the fire blight resistance quantitative trait locus of apple cultivar ‘Evereste’
Fire blight is the most destructive bacterial disease affecting apple (Malus×domestica) worldwide. So far, no resistance gene against fire blight has been characterized in apple, despite several resistance regions having been identified. A highly efficacious resistance quantitative trait locus (QTL) was localized on linkage group 12 (LG12) of the ornamental cultivar ‘Evereste’. A marker previously reported to be closely linked to this resistance was used to perform a chromosome landing. A bacterial artificial chromosome (BAC) clone of 189 kb carrying the fire blight resistance QTL was isolated and sequenced. New microsatellite markers were developed, and the genomic region containing the resistance locus was limited to 78 kb. A cluster of eight genes with homologies to already known resistance gene structures to bacterial diseases was identified and the corresponding gene transcription was verified. From this cluster, two genes were recognized in silico as the two most probable fire blight resistance genes showing homology with the Pto/Prf complex in tomato
Impact of a revised Mg(p,)Al reaction rate on the operation of the Mg-Al cycle
Proton captures on Mg isotopes play an important role in the Mg-Al cycle
active in stellar H-burning regions. In particular, low-energy nuclear
resonances in the Mg(p,)Al reaction affect the production
of radioactive Al as well as the resulting Mg/Al abundance ratio.
Reliable estimations of these quantities require precise measurements of the
strengths of low-energy resonances. Based on a new experimental study performed
at LUNA, we provide revised rates of the Mg(p,)Al
and the Mg(p,)Al reactions with corresponding
uncertainties. In the temperature range 50 to 150 MK, the new recommended rate
of the Al production is up to 5 times higher than previously
assumed. In addition, at T MK, the revised total reaction rate is a
factor of 2 higher. Note that this is the range of temperature at which the
Mg-Al cycle operates in an H-burning zone. The effects of this revision are
discussed. Due to the significantly larger Mg(p,)Al
rate, the estimated production of Al in H-burning regions is less
efficient than previously obtained. As a result, the new rates should imply a
smaller contribution from Wolf-Rayet stars to the galactic Al budget.
Similarly, we show that the AGB extra-mixing scenario does not appear able to
explain the most extreme values of Al/Al, i.e. , found
in some O-rich presolar grains. Finally, the substantial increase of the total
reaction rate makes the hypothesis of a self-pollution by massive AGBs a more
robust explanation for the Mg-Al anticorrelation observed in Globular-Cluster
stars
Activation measurement of the 3He(alpha,gamma)7Be cross section at low energy
The nuclear physics input from the 3He(alpha,gamma)7Be cross section is a
major uncertainty in the fluxes of 7Be and 8B neutrinos from the Sun predicted
by solar models and in the 7Li abundance obtained in big-bang nucleosynthesis
calculations. The present work reports on a new precision experiment using the
activation technique at energies directly relevant to big-bang nucleosynthesis.
Previously such low energies had been reached experimentally only by the
prompt-gamma technique and with inferior precision. Using a windowless gas
target, high beam intensity and low background gamma-counting facilities, the
3He(alpha,gamma)7Be cross section has been determined at 127, 148 and 169 keV
center-of-mass energy with a total uncertainty of 4%. The sources of systematic
uncertainty are discussed in detail. The present data can be used in big-bang
nucleosynthesis calculations and to constrain the extrapolation of the
3He(alpha,gamma)7Be astrophysical S-factor to solar energies
The 3He(alpha,gamma)7Be S-factor at solar energies: the prompt gamma experiment at LUNA
The 3He(alpha,gamma)7Be process is a key reaction in both Big-Bang
nucleosynthesis and p-p chain of Hydrogen Burning in Stars. A new measurement
of the 3He(alpha,gamma)7Be cross section has been performed at the INFN Gran
Sasso underground laboratory by both the activation and the prompt gamma
detection methods. The present work reports full details of the prompt gamma
detection experiment, focusing on the determination of the systematic
uncertainty. The final data, including activation measurements at LUNA, are
compared with the results of the last generation experiments and two different
theoretical models are used to obtain the S-factor at solar energies.Comment: Accepted for publication in Nucl. Phys.
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