28 research outputs found
Evolution of wave packets in quasi-1D and 1D random media: diffusion versus localization
We study numerically the evolution of wavepackets in quasi one-dimensional
random systems described by a tight-binding Hamiltonian with long-range random
interactions. Results are presented for the scaling properties of the width of
packets in three time regimes: ballistic, diffusive and localized. Particular
attention is given to the fluctuations of packet widths in both the diffusive
and localized regime. Scaling properties of the steady-state distribution are
also analyzed and compared with theoretical expression borrowed from
one-dimensional Anderson theory. Analogies and differences with the kicked
rotator model and the one-dimensional localization are discussed.Comment: 32 pages, LaTex, 11 PostScript figure
Inclusive pion double charge exchange on Oxygen(16) at 0.6-1.1 GeV
The inclusive pion double charge exchange (DCX) on oxygen nuclei has been
measured in the region where additional pion production is kinematically
forbidden. The experiment was performed at ITEP PS at incident pi- kinetic
energies T_0= 0.59, 0.75 and 1.1 GeV. The integrated forward differential cross
section was found to decrease with energy slowly. At 1.1 GeV it exceeds the
theoretical prediction within the conventional sequential single charge
exchange mechanism with a neutral pion in the intermediate state (Glauber
elastic rescattering) by about half an order of magnitude. The sequential
mechanism with two pions in the intermediate state (Glauber inelastic
rescatterings), which was proposed recently, seems to be able to explain the
observed slow energy dependence and allows to predict the DCX cross section for
higher energies.Comment: 27 pages, 13 figures. Minor corrections, one figure added. Accepted
in NP
A Systematic Study of the Features Critical for Designing a High Avidity Multivalent Aptamer
DNA Aptamers to Human Immunodeficiency Virus Reverse Transcriptase Selected by a Primer-Free SELEX Method: Characterization and Comparison with Other Aptamers
Factors Associated With Local Tumor Control and Complications After Thermal Ablation of Colorectal Cancer Liver Metastases: A 15-year Retrospective Cohort Study
Thermal ablation of colorectal cancer liver metastases with minimum margin > 10 mm offers the best local tumor control. Biliary complications occurred only in patients that received hepatic artery infusion especially in the face of pre-existing biliary dilatation, exposure to bevacizumab, and ablation with minimum margin > 10 mm. For patients at risk, such as those in the hepatic artery infusion group, a margin of 6 to 10 mm offers 76% local tumor control rate and 4% major biliary complications incidence.Introduction: The purpose of this study was to identify risk factors associated with local tumor progression-free survival (LTPFS) and complications after colorectal liver metastases (CLM) thermal ablation (TA). Patients and Methods: This retrospective analysis included 286 patients with 415 CLM undergoing TA (radiofrequency and microwave ablation) in 378 procedures from January 2003 to July 2017. Prior hepatic artery infusion (HAI), bevacizumab, pre-existing biliary dilatation, ablation modality, minimal ablation margin (MM), prior hepatectomy, CLM number, and size were analyzed as factors influencing complications and LTPFS. Statistical analysis included the Kaplan-Meier method, Cox proportional hazards model, competing risk analysis, univariate/multivariate logistic/exact logistic regressions, and the Fisher exact test. Complications were reported according to modified Society of Interventional Radiology guidelines. Results: The median follow-up was 31 months. There was no LTP for MM > 10 mm. Smaller tumor size, increased MM, and prior hepatectomy correlated with longer LTPFS. The major complications occurred following 28 (7%) of 378 procedures. There were no biliary complications in HAI-naive patients, versus 11% in HAI patients (P 10 mm. In HAI patients, ablation with 6 to 10 mm and > 10 mm MM resulted in major biliary complication rates of 4% and 21% (P = .0011), with corresponding LTP rates of 24% and 0% (P = .0033). In HAI-naive patients, the LTP rates for 6 to 10 mm and > 10 mm MM were 27% and 0%, respectively. Conclusions: No LTP was seen for MM > 10 mm. Biliary complications occurred only in HAI patients, especially in those with biliary dilatation, bevacizumab, and MM > 10 mm. In HAI patients, MM of 6 to 10 mm resulted in 76% local tumor control and 4% major biliary complications incidence. (C) 2020 Published by Elsevier Inc
Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study
International audienceObservational studies have shown an association between obesity and venous thromboembolism (VTE) but it is not known if observed associations are causal, due to reverse causation or confounding bias. We conducted a Mendelian Randomization study of body mass index (BMI) and VTE. We identified 95 single nucleotide polymorphisms (SNPs) that have been previously associated with BMI and assessed the association between genetically predicted high BMI and VTE leveraging data from a previously conducted GWAS within the INVENT consortium comprising a total of 7507 VTE cases and 52,632 controls of European ancestry. Five BMI SNPs were associated with VTE at P < 0.05, with the strongest association seen for the FTO SNP rs1558902 (OR 1.07, 95% CI 1.02–1.12, P = 0.005). In addition, we observed a significant association between genetically predicted BMI and VTE (OR = 1.59, 95% CI 1.30–1.93 per standard deviation increase in BMI, P = 5.8 × 10−6). Our study provides evidence for a causal relationship between high BMI and risk of VTE. Reducing obesity levels will likely result in lower incidence in VTE