Applying knowledge management strategies to economic development in sub-Saharan Africa

Sustainability looks to achieve best outcomes for human and natural environments both now and in the indefinite future. It relates to the continuity of economic, social, institutional and environmental aspects of human society, as well as the non-human environment. This paper examines economic development as one aspect of sustainability, with a focus on knowledge management as an economic development strategy. Using Grey’s categories of knowledge management, the authors address sustainable economic development in the context of sub-Saharan Africa. Production capability is no longer completely dependent on capital and equipment; information and knowledge assets are increasingly important. In this information economy, success comes from harnessing the information and knowledge of a community. Such “indigenous knowledge,” local and often tacit, exists in every community, every region and every country. This knowledge is useful in identifying new entrepreneurial opportunities, as well as for sustaining and advancing local businesses. Sub-Saharan Africa provides an excellent case study. No other region of the world is in more dire need of development. The 700 million people in this area face tremendous challenges, including the world’s highest incidence of HIV/AIDS, deep poverty, unemployment, political instability, and a host of related problems. Key factors for using knowledge management as an economic development strategy in the region will include ICT (Information and Communication Technologies) literacy; uncovering and developing local intellectual assets; capturing tacit knowledge; internal and external knowledge sharing; and managing political, social and technological barriers. Other specific recommendations include promoting ICT literacy through training programs; leveraging internet and email technologies for community building; investing financial resources in R & D; and developing metrics for outcome assessment.Keywords: Knowledge management, economic development, sub-Saharan Africa

Further Comparisons of Finite Difference Schemes for Computational Modelling of Biosensors

Simulations are presented for a reaction-diffusion system within a thin layer containing an enzyme, fed with a substrate from the surrounding electrolyte. The chemical term is of the nonlinear Michaelis-Menten type and requires a technique such as Newton iteration for solution. It is shown that approximating the nonlinear chemical term in these systems by a linearised form reduces both the accuracy and, in the case of second-order methods such as Crank-Nicolson, reduces the global error order from O(δT2) to O(δT). The first-order methods plain backwards implicit with and without linearisation, and Crank-Nicolson with linearisation are all of O(δT) and very similar in performance, requiring, for a given accuracy target, an order of magnitude more CPU time than the efficient methods backward implicit with extrapolation and Crank-Nicolson, both with Newton iteration to handle the nonlinearity. Steady state computations agree with expectations, tending to the known solutions for limiting cases. The Crank-Nicolson method shows some concentration oscillations close to the outer layer boundary but this does not propagate to the inner boundary at the electrode. The backward implicit methods do not result in such oscillations and if concentration profiles are of interest, may be preferred

A narrative review on spinal deformities in people with cerebral palsy: Measurement, norm values, incidence, risk factors and treatment

Spinal deformities are common in people with cerebral palsy (CP), and there is a concern of an increase during the adult ageing period. There is especially a worry about the increase of scoliosis, thoracic hyperkyphosis, lumbar hyperlordosis, spondylolysis and spondylolisthesis incidence, though supporting literature is lacking. Therefore, the aim of this narrative review is to provide a scientific overview of how spinal curvatures should be measured, what the norm values are and the incidence in people with CP, as well as a description of the risk factors and the treatment regimens for these spinal abnormalities. This review can be used as a guideline relevant for a range of clinicians, including orthopaedic and neurosurgeons, radiologists, physiotherapists, and biokineticists, as well as academics

Molecular detection of carbapenemase-producing genes in referral Enterobacteriaceae in South Africa: A short report

Molecular confirmation of carbapenemase-producing Enterobacteriaceae (CPE) was introduced in South Africa (SA) at the end of 2011. We report on the detection of these resistance genes based on referral isolates. Enterobacteriaceae with non-susceptibility to any of the carbapenems according to defined criteria for antimicrobial susceptibility testing results were sent to a reference laboratory. A proportion of isolates had limited demographic, epidemiological and clinical data available. Organism identification was reconfirmed using reference laboratory methods, and the presence of carbapenemases was confirmed with a real-time polymerase chain reaction. We analysed 1 503 significant isolates received for confirmation from the National Health Laboratory Service and some private laboratories during 2012 - 2015 and confirmed one or more carbapenemase-producing genes in 68% of isolates, the most common organism being Klebsiella pneumoniae (60%). The most common carbapenemase genes were blaNDM, followed by blaOXA-48 and its variants. BlaOXA-48 and its variants demonstrated non-susceptibility to ertapenem in 89% of the isolates when analysed by the phenotypic method, and to ceftazidime in 34%. Overall, the detection rate for carbapenemases in K. pneumoniae blood isolates in the public sector was 1.9% during the 4-year period. This report indicates the presence of CPE in SA, and it is important for all healthcare workers to be aware of this major public health threat so that infection prevention and control measures can be implemented to prevent the spread of CPE in healthcare facilities

Hamming weights and Betti numbers of Stanley-Reisner rings associated to matroids

To each linear code over a finite field we associate the matroid of its parity check matrix. We show to what extent one can determine the generalized Hamming weights of the code (or defined for a matroid in general) from various sets of Betti numbers of Stanley-Reisner rings of simplicial complexes associated to the matroid

Age of diagnosis for congenital hearing loss at Universitas Hospital, Bloemfontein

Background. Congenital hearing loss affects 3 - 6/1 000 children worldwide. The benefits of early identification of hearing loss and early intervention have been clearly established. There are no previous studies reporting on the age of diagnosis of congenital hearing loss in the Free State province.Objectives. To determine the age of diagnosis of congenital hearing loss in the Otorhinolaryngology Clinic at Universitas Hospital. Secondary aims included determining age at first visit, as well as the time delay between first visit and diagnosis, and documenting any interventions which took  place.Methods. A retrospective, descriptive study was undertaken, analysing data from 2001 to 2010.Results. A total of 260 cases of congenital hearing loss were analysed. The median age of diagnosis of hearing loss was 44.5 months. The median age of first visit was 40.9 months, and the median delay between first visit and diagnosis was 49 days.Conclusions. The median age of diagnosis far exceeds national and  international benchmarks. This has a profoundly negative impact on the development and outcomes of children with hearing loss. These results have been used to motivate for the expansion of hearing screening and diagnostic services in the province

Continental-scale assessment of micro-pumped hydro energy storage using agricultural reservoirs

The transition to low-carbon power systems necessitates cost-effective energy storage solutions. This study provides the first continental-scale assessment of micro-pumped hydro energy storage and proposes using agricultural reservoirs (farm dams) to significantly reduce construction costs. The continent of Australia is used as a representative case study for other arid and temperate regions internationally. From a new survey of its 1.7 million farm dams, we identified 30,295 promising pumped hydro sites in dam-to-dam and dam-to-river reservoir configurations. The average site had nearby reservoirs (132 m) with a high head height (32 m) and substantial discharge capacity (52 kWh). We then benchmarked a representative micro-pumped hydro site to a commercially available lithium-ion battery for a solar-powered irrigation system. Despite a low discharge efficiency (68%), pumped hydro storage was 30% less expensive (0.215 USD/kWh) for larger single-cycle loads (∼41 kWh/day) due to its high storage capacity. By capitalising on existing farm dams, micro-pumped hydro energy storage may support the uptake of reliable, low-carbon power systems in agricultural communities

The flavor symmetry in the standard model and the triality symmetry

A Dirac fermion is expressed by a 4 component spinor which is a combination of two quaternions and which can be treated as an octonion. The octonion possesses the triality symmetry, which defines symmetry of fermion spinors and bosonic vector fields. The triality symmetry relates three sets of spinors and two sets of vectors, which are transformed among themselves via transformations $G_{23}, G_{12}, G_{13}$, $G_{123}$ and $G_{132}$. If the electromagnetic (EM) interaction is sensitive to the triality symmetry, i.e. EM probe selects one triality sector, EM signals from the 5 transformed world would not be detected, and be treated as the dark matter. According to an astrophysical measurement, the ratio of the dark to ordinary matter in the universe as a whole is almost exactly 5. We expect quarks are insensitive to the triality, and triality will appear as three times larger flavor degrees of freedom in the lattice simulation.Comment: 16 pages 8 figures, To be published in International Journal of Modern Physics

Molecular detection of carbapenemase-producing genes in referral Enterobacteriaceae in South Africa: A short report

Molecular confirmation of carbapenemase-producing Enterobacteriaceae (CPE) was introduced in South Africa (SA) at the end of 2011. We report on the detection of these resistance genes based on referral isolates. Enterobacteriaceae with non-susceptibility to any of the carbapenems according to defined criteria for antimicrobial susceptibility testing results were sent to a reference laboratory. A proportion of isolates had limited demographic, epidemiological and clinical data available. Organism identification was reconfirmed using reference laboratory methods, and the presence of carbapenemases was confirmed with a real-time polymerase chain reaction. We analysed 1 503 significant isolates received for confirmation from the National Health Laboratory Service and some private laboratories during 2012 - 2015 and confirmed one or more carbapenemase-producing genes in 68% of isolates, the most common organism being Klebsiella pneumoniae (60%). The most common carbapenemase genes were blaNDM, followed by blaOXA-48 and its variants. BlaOXA-48 and its variants demonstrated non-susceptibility to ertapenem in 89% of the isolates when analysed by the phenotypic method, and to ceftazidime in 34%. Overall, the detection rate for carbapenemases in K. pneumoniae blood isolates in the public sector was 1.9% during the 4-year period. This report indicates the presence of CPE in SA, and it is important for all healthcare workers to be aware of this major public health threat so that infection prevention and control measures can be implemented to prevent the spread of CPE in healthcare facilities

Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions

Purpose To provide whole-body physiologically based pharmacokinetic (PBPK) models of the potent clinical organic anion transporter (OAT) inhibitor probenecid and the clinical OAT victim drug furosemide for their application in transporter-based drug-drug interaction (DDI) modeling. Methods PBPK models of probenecid and furosemide were developed in PK-Sim®. Drug-dependent parameters and plasma concentration-time profiles following intravenous and oral probenecid and furosemide administration were gathered from literature and used for model development. For model evaluation, plasma concentration-time profiles, areas under the plasma concentration–time curve (AUC) and peak plasma concentrations (Cmax) were predicted and compared to observed data. In addition, the models were applied to predict the outcome of clinical DDI studies. Results The developed models accurately describe the reported plasma concentrations of 27 clinical probenecid studies and of 42 studies using furosemide. Furthermore, application of these models to predict the probenecid-furosemide and probenecid-rifampicin DDIs demonstrates their good performance, with 6/7 of the predicted DDI AUC ratios and 4/5 of the predicted DDI Cmax ratios within 1.25-fold of the observed values, and all predicted DDI AUC and Cmax ratios within 2.0-fold. Conclusions Whole-body PBPK models of probenecid and furosemide were built and evaluated, providing useful tools to support the investigation of transporter mediated DDIs