An Examination of the Moderating Effect of Proactive Coping in NICU Nurses

The NICU environment is unique in that the patient population consists of critically ill neonates. Research has revealed that there are increased levels of depression, secondary traumatic stress, and burnout in nurses. Problem solving and support seeking coping strategies have been shown to be associated with lower levels of burnout and increased patient and job satisfaction in general staff nurses. Multiple linear regression and a hierarchical stepwise technique was used to conduct moderator analyses assessing whether the use of problem solving or support seeking strategies moderated the relationship between secondary traumatic stress levels and burnout as well as between depressive symptomology and burnout in NICU nurses. Of the 62 participants, the majority identified as White (64.5%) and female (98.4%) with a mean age of 41.65 years (SD = 13.05). Support seeking coping skills significantly moderated the relationship between secondary traumatic stress symptoms and burnout symptoms in NICU nurses. Post-hoc analysis indicated that NICU nurses who reported higher levels of secondary traumatic stress symptoms and engaged in higher levels of support seeking coping skills, also reported higher levels of burnout when compared with nurses who reported lower levels of support seeking coping skills. Problem solving coping did not moderate the relationship between depressive symptoms and burnout. These results indicate the need to better understand the risk and protective factors related to stress and burnout in NICU nurses. These findings can be used to inform the development of programs that could promote the well-being and coping of nurses experiencing mental health difficulties or burnout and foster a healthy work environment for all NICU nurses so that they can provide the best possible intervention to the vulnerable infants they work with

Approximation Formulations for the Single Product Capacitated Lot Size Problem

We consider two approximation formulations for the single product capacitated lot size problem. They correspond respectively to a restriction of the number of production policies and to the rounding of demands up to multiples of a constant. After briefly reviewing the literature within a new % ~ framework, we discuss the relations between these approximation formulations. Next, we provide relative error bounds and algorithms for solving the approximation problems. We demonstrate that these approximation formulations require a significantly smaller number of calculations than the original formulation, and that the relative error bounds are satisfactory for practical purposes

Stability of Relativistic Matter with Magnetic Fields for Nuclear Charges up to the Critical Value

We give a proof of stability of relativistic matter with magnetic fields all the way up to the critical value of the nuclear charge $Z\alpha=2/\pi$.Comment: LaTeX2e, 12 page

Analysis of the Uncapacitated Dynamic Lot Size Problem

In this paper we provide worst case error bounds for several heuristics for the uncapacitated dynamic lot size problem. We propose two managerially oriented procedures and show that they have a relative worst case error bound equal to two, and develop similar analyses for methods known as the "Silver and Meal" heuristics, the part period balancing heuristics, and economic order quantity heuristics (expressed in terms of a time supply of demand).We also present results on aggregation and partitioning of the planning horizon

An Examination of the Neural Basis of Self-Reflectivity in Schizophrenia

Metacognition is a term that refers to the act of thinking about thinking. The self-reflective aspect of metacognition specifically, has been shown to be impaired in patients diagnosed with schizophrenia. The Default Mode Network (DMN) is a set of cortical regions that demonstrate coordinated activation during the resting state of the brain. The DMN has been linked with various aspects of self-awareness and has been hypothesized as a possible source of dysfunction in patients diagnosed with schizophrenia. The current study bridged these findings by using electrophysiological measures to investigate the neural basis of self-reflectivity in a psychiatric group. A Repeated Measures ANOVA with a between-subjects factor of group (healthy controls and the psychiatric group) and within-subjects factors of task (resting-state EEG and self-referential resting-state EEG) and region (frontal and central) was used to evaluate group differences between healthy controls and the psychiatric group, for each frequency band and task at frontal and central electrode sites separately. Of the 13 participants, the majority identified as Caucasian (38.5%) and female (53.8%), with a mean age of 33.60 for the healthy control group (SD = 15.27) and 37.63 for the psychiatric group (SD = 11.22). A main effect of group was found in the theta frequency band, indicating that the psychiatric group showed increased theta activity compared to healthy controls during resting-state EEG. There were no significant group by task interactions. Analyses also revealed a significant, strong positive correlation between MAS-A ratings of self-reflectivity and beta frequency band activity in the central region during self-referential resting-state EEG for healthy control participants. Lastly, analyses revealed a statistically significant, strong negative correlation between MAS-A ratings of self-reflectivity and theta frequency band activity in the central region during resting-state EEG for the psychiatric group. Continued research using electrophysiological measures to investigate the neural basis of self-reflectivity in patients diagnosed with schizophrenia is vital to increasing their ability to engage effectively in treatment and create the insight needed to view themselves as an active participant in their own families and communities

Comparison of Audiovisual and Paper-Based Materials for 1-Time Informed Consent for Research in Prison: A Randomized Clinical Trial.

Importance Few studies are available on informed consent (IC) among detained persons, even with ethics being a critical aspect of prison research. In IC research, audiovisual material seems to improve understanding and satisfaction compared with conventional paper-based material, but findings remain unclear. Objective To compare audiovisual and paper-based materials for 1-time general IC for research in prisons. Design, Setting, and Participants This cross-sectional randomized clinical trial was conducted in 2 corrections facilities in Switzerland (an adult prison and a juvenile detention center). The study was conducted from December 14, 2019, to December 2, 2020, in the adult prison and from January 15, 2020, to September 9, 2021, in the juvenile detention center. In the adult prison, study participation was offered to detained persons visiting the medical unit (response rate, 84.7%). In the juvenile detention center, all newly incarcerated adolescents were invited to participate (response rate, 98.0%). Interventions Participants were randomized to receive paper-based conventional material or to watch a 4-minute video. Materials included the same legal information, as required by the Swiss Federal Act on Research Involving Human Beings. Main Outcomes and Measures The main outcome was acceptance to sign the IC form. Secondary outcomes included understanding, evaluation, and time to read or watch the IC material. Results The study included 190 adults (mean [SD] age, 35.0 [11.8] years; 190 [100%] male) and 100 adolescents (mean [SD] age, 16.0 [1.1] years; 83 [83.0%] male). In the adult prison, no significant differences were found between groups in acceptance to sign the IC form (77 [81.1%] for paper-based material and 81 [85.3%] for audiovisual material; P = .39) and to evaluate it (mean [SD] correct responses, 5.09 [1.13] for paper-based material and 5.01 [1.07] for audiovisual material; P = .81). Understanding was significantly higher in the audiovisual material group (mean [SD] correct responses, 5.09 [1.84]) compared with the paper-based material group (mean [SD] correct responses, 4.61 [1.70]; P = .04). In the juvenile detention center, individuals in the audiovisual material group were more likely to sign the IC form (44 [89.8%]) than the paper-based material group (35 [68.6%], P = .006). No significant difference was found between groups for understanding and evaluation. Adults took a mean (SD) of 5 (2) minutes to read the paper material, and adolescents took 7 (3) minutes. Conclusions and Relevance Given the small benefit of audiovisual material, these findings suggest that giving detained adults and prison health care staff a choice regarding IC material is best. For adolescents, audiovisual material should be provided. Future studies should focus on increasing understanding of the IC process. Trial Registration ClinicalTrials.gov Identifier: NCT05505058

neXtProt: a knowledge platform for human proteins

neXtProt (http://www.nextprot.org/) is a new human protein-centric knowledge platform. Developed at the Swiss Institute of Bioinformatics (SIB), it aims to help researchers answer questions relevant to human proteins. To achieve this goal, neXtProt is built on a corpus containing both curated knowledge originating from the UniProtKB/Swiss-Prot knowledgebase and carefully selected and filtered high-throughput data pertinent to human proteins. This article presents an overview of the database and the data integration process. We also lay out the key future directions of neXtProt that we consider the necessary steps to make neXtProt the one-stop-shop for all research projects focusing on human protein

neXtProt: a knowledge platform for human proteins

neXtProt (http://www.nextprot.org/) is a new human protein-centric knowledge platform. Developed at the Swiss Institute of Bioinformatics (SIB), it aims to help researchers answer questions relevant to human proteins. To achieve this goal, neXtProt is built on a corpus containing both curated knowledge originating from the UniProtKB/Swiss-Prot knowledgebase and carefully selected and filtered high-throughput data pertinent to human proteins. This article presents an overview of the database and the data integration process. We also lay out the key future directions of neXtProt that we consider the necessary steps to make neXtProt the one-stop-shop for all research projects focusing on human proteins