Architecture and stratigraphy of the Lower Silurian Guelph Formation, Lockport Group, southern Ontario and Michigan

The Lower Silurian Lockport Group in Ontario and Michigan comprises, in ascending order: Gasport, Goat Island, Eramosa, and Guelph formations. Guelph facies architecture reveals deposition on an underlying carbonate ramp of Eramosa and/or Goat Island carbonates that dipped towards the Appalachian Basin. Temporally, Guelph facies reflect initial open marine transgressive phases that become increasingly restricted marine and karstic upward. Spatially, the facies display the most restricted marine and karstic fabrics in the central portion of the ‘Michigan Basin’ and are most open marine to the east. Newly acquired regional data supports the re-interpretation of the classic Guelph-pinnacle reef models as karst towers that formed in a paleokarst basin. This new regional perspective of the classic ‘Guelph-play’ will help to explain some of the challenges faced by oil/gas explorationists trying to both map/predict production zones and encourage re-evaluation of existing plays and enable successful exploration of new targets

Activated Carbon Injection for Mercury Control in Coal-Fired Boilers

Mercury is a toxic compound causing numerous health problems in humans. One of the ways that mercury is released into the atmosphere is through the burning of coal. The Environmental Protection Agency estimates that the United States consumes i billion tons of coal per year and coal-fired utilities emit 73 tons of mercury per year. Though there arc currently no regulations on mercury emissions, it will remain an environmental concern. Activated carbon (AC) injection is a proposed technology for mercury control in coal-fired boilers. We are interested in determining whether the diffusion rate or the absorptive capacity of the sorbent particle limits mercury absorption. A mathematical model was developed to estimate mercury diffusion rates in flue gas. With the model, diffusion rates were studied for mono-sized particles, particle distributions, and temperature variations. The diffusion rates appear to be the limiting factor except in the cases of small particle diameters (less than two microns at 95% mercury capture) and high temperatures. The results show that carbon requirements increase as the square of the particle diameter. Temperature has very little effect on mercury diffusion to the smaller particles but becomes increasingly important as the size increases. Particle distributions have a great impact on the carbon requirements. The mono-sized particle carbon requirements increased by factors of between 2.8 and 32 depending on the mean particle diameter and the geometric standard deviation. There is ongoing research to improve sorbent technology. The Energy and Environmental Research Center has developed a promising new sorbent, indole- impregnated activated carbon. To estimate the production cost of the new sorbent, an economic analysis was performed for the production of 500 tons/yea A high production cost of S7.83/lb. caused the project to be economically unattractive. The raw matenals made up 62% of the total product cost. The product cost was fairly insensitive to deviations of all factors except the costs of indole and base carbon. Significant reduction of the production cost must come through the lowering of raw material costs

MINING SARS-COV-2 PHYLOGENETIC TREES TO ESTIMATE CIRCULATING INFECTIONS AND PATTERNS OF MIGRATION

The SARS-CoV-2 pandemic led to the formation of very large databases of genomic viral data. These databases contain information on transmission dynamics, emergence and evolution of SARS-CoV-2. However, extracting this information from sequences is difficult, as most methods of analyzing viral genomes were developed for smaller data sets. Therefore, my objective was to develop new fast estimators of the number of infections (I) and the rate of migration based on simple features of SARS-CoV-2 phylogenies. I simulated pathogen evolution using a susceptible-exposed-infectious-recovered (SEIR) model of pathogen spread, reconstructing evolution using CoVizu. For simulations of I, I varied the total number of infections when a final sample was obtained. For simulations of migration rates, I simulated independent groups of infections and varied the rates of movement between these groups. I then extracted summary statistics from the simulation output and developed general linear models (GLMs) and Markov models to predict I and migration rates respectfully. I evaluated the models using validation data and veritable SARS-CoV-2 data. The GLMs formulated to predict I showed significant promise, especially when predicting when there were less than 1 million infections. The Markov models developed to predict migration rates were less successful. However, the simulation pipeline formulated to test the Markov models may be used for further development of efficient methods to estimate migration rates. This research will help inform public health officials on SARS-CoV-2 spread between countries and emerging variants that may become variants of concern. Additionally, the algorithms are flexible and, with new training, may be applied to future outbreaks of novel viral pathogens

Human factors considerations in designing for infection prevention and control in neonatal care – findings from a pre-design inquiry

Qualitative data collection methods drawn from the early stages of human-centred design frameworks combined with thematic analysis were used to develop an understanding of infection prevention practice within an existing neonatal intensive care unit. Findings were used to generate a framework of understanding which in turn helped inform a baseline approach for future research and design development. The study revealed that a lack of clarity between infection transmission zones and a lack of design attributes needed to uphold infection prevention measures may be undermining healthcare workers’ understanding and application of good practice. The issue may be further complicated by well-intentioned behavioural attitudes to meeting work objectives; undue influences from spatial constraints; the influence of inadvertent and excessive touch-based interactions; physical and/or cognitive exertion to maintain transmission barriers; and the impact of expanding job design and increased workload to supplement for lack of effective barriers

Habits of Mind and the Split-Mind Effect: When Computer-Assisted Qualitative Data Analysis Software is Used in Phenomenological Research

When Marshall McLUHAN famously stated "the medium is the message," he was echoing Martin HEIDEGGER's assertion that through our use of technology we can become functions of it. Therefore, how does adopting computer-assisted qualitative data analysis software affect our research activities and, more importantly, our conception of research? These questions are explored by examining the influence NVivo had upon an interdisciplinary phenomenological research project in health ethics. We identify the software's effects and situate our decision to use it within the Canadian health sciences research landscape. We also explore the challenges of remaining true to our project's philosophical foundations, as well as how NVivo altered our being-in-the-world as researchers. This case demonstrates McLUHAN's claim that new technologies invariably initiate new practices and modes of being, and urges researchers to attend to how we are both shaping and being shaped by software.URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs120227Cuando Marshall McLUHAN afirmo "El medio es el mensaje" estaba haciendo eco a la afirmación de Martín HEIDEGGER de que a través de nuestro uso de la tecnología podemos convertirnos en funciones de ello. Por consiguiente, ¿Cómo afecta el análisis cualitativo de datos con asistencia de una computadora nuestras actividades de investigación y aún más importante, nuestra concepción de la investigación? Se exploran estas preguntas al examinar la influencia que NVivo tuvo sobre un proyecto de investigación fenomenológica interdisciplinaria en ética de salud. Identificamos los efectos del software y situamos nuestra decisión de usarlo en el horizonte de la investigación de ciencias de la salud canadienses. Exploramos los desafíos de mantenernos fieles a los fundamentos filosóficos del proyecto, así como también la forma en que NVivo alteró nuestro ser-en-el-mundo como investigadores. Este caso demuestra la afirmación de McLUHAN sobre que invariablemente las nuevas tecnologías inician nuevas prácticas y modos de ser, y urge a que los investigadores pongan atención sobre como forman, a la vez que se van formando, por el software.URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs120227Als Marshall McLUHAN seinen berühmten Satz "Das Medium ist die Botschaft" formulierte,  fand sich eine ähnliche Vorstellung in Martin HEIDEGGERs Behauptung, dass wir durch die Nutzung von Technologie zu deren Teil werden.  Unsere Frage ist – von hier ausgehend – in welcher Weise die Nutzung computergestützter qualitativer Analyse-Software unsere Forschungsaktivitäten affiziert und  – noch zentraler – unser Konzept von Forschung? Zu deren Beantwortung haben wir uns mit dem Einfluss von NVivo auf ein interdisziplinäres phänomenologisches Forschungsprojekt befasst, das in der Gesundheitsethik angesiedelt ist. Wir identifizieren die Effekte der Software auf unsere Forschung, indem wir bereits unsere Entscheidung für ihre Nutzung in dem aktuellen Stand der kanadischen Gesundheitswissenschaften situieren. Wir befassen uns auch mit der Herausforderung, den philosophischen Grundlagen unserer Forschung treu zu bleiben und mit der Frage, wie NVivo unser "In-der-Welt-sein" als Forschende verändert hat.  Unser Beispiel zeigt, McLUHAN folgend, dass neue Technologien notwendig neue Praktiken und Seinsweisen hervorbringen, und es verweist Forschende darauf zu reflektieren, wie Software für Forschungsarbeiten angepasst wird und wie sie umgekehrt uns selbst "anpasst".URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs12022

Occupational therapy for people with psychotic conditions in community settings: a pilot randomized controlled trial

OBJECTIVES: To investigate the effectiveness of a long established intervention, occupational therapy for people with psychotic conditions, and to inform future research designs. DESIGN: A pilot randomized controlled trial. SETTING: Two community mental health teams in a UK city. PARTICIPANTS: Forty-four adults with schizophrenia or other psychotic conditions, and functional problems. INTERVENTIONS: Twelve months of individualized occupational therapy in community settings, as an adjunct to usual care and compared to treatment as usual. A two to one randomization ratio was used in favour of occupational therapy. OUTCOME MEASURES: Social Functioning Scale, Scale for the Assessment of Negative Symptoms and employment. RESULTS: Both groups' scores on Social Functioning Scale and Scale for the Assessment of Negative Symptoms showed significant improvement over 12 months. The Social Functioning Scale overall mean difference for occupational therapy was 2.33, P=0.020 and for treatment as usual was 6.17, P=0.023. The Scale for the Assessment of Negative Symptoms total mean difference for occupational therapy was -16.25, P<0.001 and for treatment as usual was -17.36, P= 0.011. There were no differences between the two groups on any of the outcome measures. After 12 months the occupational therapy group showed clinically significant improvements that were not apparent in the control group. These were in four subscales of the Social Functioning Scale: relationships, independence performance, independence competence and recreation. Out of 30 people receiving occupational therapy those with a clinical level of negative symptoms reduced from 18 (64%) to 13 (46%), P=0.055. CONCLUSION: This pilot study suggested that individualized occupatio

Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, but may involve the loss of tolerance to posttranslationally modified (citrullinated) antigens. We have demonstrated that this modification leads to a selective increase in antigenic peptide affinity for major histocompatibility complex (MHC) class II molecules that carry the RA-associated shared epitope, such as HLA-DRB1*0401 (DR4). We describe the induction of arthritis in DR4-IE transgenic (tg) mice with citrullinated fibrinogen, a protein commonly found in inflamed synovial tissue and a frequent target of autoantibodies in RA patients. The disease induced in these mice was characterized by synovial hyperplasia followed by ankylosis, but lacked a conspicuous polymorphonuclear cell infiltrate. Immunological analysis of these mice through T cell epitope scanning and antibody microarray analysis identified a unique profile of citrulline-specific reactivity that was not found in DR4-IE tg mice immunized with unmodified fibrinogen or in wild-type C57BL/6 mice immunized with citrullinated fibrinogen, two conditions where arthritis was not observed. These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated MHC class II molecules

Meta-analysis of the Association between HLA-DRB1 Allele and Rheumatoid Arthritis Susceptibility in Asian Populations

The aims of this study were to summarize results on the association of HLA-DRB1 with rheumatoid arthritis (RA) in Asians and to determine if the shared epitope (SE) hypothesis could explain the meta-analysis results. Among the papers published between January 1987 and July 2006 on RA susceptibility in Asian-Mongoloid populations (Korean, Japanese, Chinese, and Thai), 12 were selected for the meta-analysis. Mongoloid-Asian patients with RA had significantly higher frequencies of HLA-DRB1*0101, *0401, *0410, and *1001 than controls (OR 1.5-2.1, p<0.05 for association). When analyses were restricted to more ethnically homogeneous populations, HLA-DRB1*0405 showed a significant susceptibility to RA in Koreans (OR 5.65, 95% CI 4.32-7.39), whereas the HLA-DRB1*0301, *0403, *0406, *0701, *1301, and *1405 alleles showed protective association with RA (OR 0.32-0.70, p<0.05 for association). In conclusion, it was found that HLA-DRB1 *0101, *0401, *0405, *0410, and *1001 are susceptible, while HLA-DRB1*0301, *0403, *0406, *0701, *1301, and *1405 are protective in Asian-Mongoloids. All the RA-associated alleles except DRB1*0301 could be explained by the structural model supporting the SE hypothesis that RA susceptibility is determined by the combination of amino acid residues at HLA-DR β71 and β74, not by β71 alone