612 research outputs found
Limitations of balloon sinuplasty in frontal sinus surgery
Balloon sinuplasty is a tool that is used to treat selected patients with paranasal sinus pathologies. No studies have investigated the aetiology of failed access to the frontal sinus. The aim of our study was to specify the intraoperative technical failure rate and to analyse the aetiology of the failed access to predict potential technical difficulties before surgery. We retrospectively analysed the charts of patients who underwent balloon sinuplasty from November 2007 to July 2010 at three different ENT-Centres. CT-analysis of the patients with failed access was performed. Of the 104 frontal sinuses, dilation of 12 (12%) sinuses failed. The anatomy of all failed cases revealed variations in the frontal recess (frontoethmoidal-cell, frontal-bulla-cell or agger-nasi-cell) or osteoneogenesis. In one patient, a lymphoma was overlooked during a balloon only procedure. The lymphoma was diagnosed 6months later with a biopsy during functional endoscopic sinus surgery. In complex anatomical situations of the frontal recess, balloon sinuplasty may be challenging or impossible. In these situations, it is essential to have knowledge of classical functional endoscopic sinus surgery of the frontal recess area. The drawbacks of not including a histopathologic exam should be considered in balloon only procedure
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat
Recent evidence implicates adult hippocampal neurogenesis in regulating behavioral
and physiologic responses to stress. Hippocampal neurogenesis occurs across the
lifespan, however the rate of cell birth is up to 300% higher in adolescent mice
compared to adults. Adolescence is a sensitive period in development where emotional
circuitry and stress reactivity undergo plasticity establishing life-long set points. Therefore
neurogenesis occurring during adolescence may be particularly important for emotional
behavior. However, little is known about the function of hippocampal neurons born during
adolescence. In order to assess the contribution of neurons born in adolescence to
the adult stress response and depression-related behavior, we transiently reduced cell
proliferation either during adolescence, or during adulthood in GFAP-Tk mice. We found
that the intervention in adolescence did not change adult baseline behavioral response in
the forced swim test, sucrose preference test or social affiliation test, and did not change
adult corticosterone responses to an acute stressor. However following chronic social
defeat, adult mice with reduced adolescent neurogenesis showed a resilient phenotype.
A similar transient reduction in adult neurogenesis did not affect depression-like behaviors
or stress induced corticosterone. Our study demonstrates that hippocampal neurons born
during adolescence, but not in adulthood are important to confer susceptibility to chronic
social defeat
If it does take a village to raise a child, how should the village do it? Insights from the kids in places initiative
Cross-sector collaborations are some of the strategies used to promote early childhood development and wellbeing. Without these collaborations, key services for families with young children may be missed or even duplicated. By drawing from experiences in Canada and Italy, we share findings from a study that aimed to understand the factors that make cross-sector collaborations (CSC) succeed or fail. Specifically, the study focused on understanding how CSC promoting early child development are created, maintained, and consolidated; and on identifying the social psychological, organizational, and economic aspects of CSC that help or hinder their functioning. Based on qualitative analysis of data gathered from four focus groups and thirteen interviews conducted across seven Canadian and Italian communities, we conclude that the success of CSC depend of a series of factors that transcend context, language and culture
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A 10Be chronology of south-western Scandinavian Ice Sheet history during the Lateglacial period
We present 34 new cosmogenic 10Be exposure ages that constrain the Lateglacial (Bølling–Preboreal) history of the Scandinavian Ice Sheet in the Lysefjorden region, south-western Norway. We find that the classical Lysefjorden moraines, earlier thought to be entirely of Younger Dryas age, encompass three adjacent moraines attributed to at least two ice sheet advances of distinctly different ages. The 10Be age of the outermost moraine (14.0 ± 0.6 ka; n = 4) suggests that the first advance is of Older Dryas age. The innermost moraine is at least 2000 years younger and was deposited near the end of the Younger Dryas (11.4 ± 0.4 ka; n = 7). After abandonment of the innermost Lysefjorden Moraine, the ice front receded quickly towards the head of the fjord, where recession was interrupted by an advance that deposited the Trollgaren Moraine at 11.3 ± 0.9 ka (n = 5). 10Be ages from the inboard side of the Trollgaren Moraine suggest final retreat by 10.7 ± 0.3 ka (n = 7). The late culmination of the Younger Dryas advance contrasts with other sectors of the Scandinavian Ice Sheet where the margin appears to have culminated earlier during the Younger Dryas stadial, followed by retreat during the middle and late part of the Younger Dryas
The role of the spin in quasiparticle interference
Quasiparticle interference patterns measured by scanning tunneling microscopy
(STM) can be used to study the local electronic structure of metal surfaces and
high temperature superconductors. Here, we show that even in non-magnetic
systems the spin of the quasiparticles can have a profound effect on the
interference patterns. On Bi(110), where the surface state bands are not
spin-degenerate, the patterns are not related to the dispersion of the
electronic states in a simple way. In fact, the features which are expected for
the spin-independent situation are absent and the observed interference
patterns can only be interpreted by taking spin-conserving scattering events
into account.Comment: 4 pages, 2 figure
Expression and in vitro properties of guinea pig IL-5: comparison to human and murine orthologs.
Interleukin-5 (IL-5) is a key mediator of eosinophilic inflammation. The biological role of this cytokine in an allergic airway inflammatory response has been widely demonstrated in guinea pigs, yet the interaction of guinea pig IL-5 (gpIL-5) with its receptor has not been studied. Experiments were performed to quantitate the interaction of gpIL-5 with gpIL-5r and to compare this affinity with that of hIL-5 and mIL-5 and their cognate receptors. The cross-species affinity and agonist efficacy were evaluated to see if gpIL-5r had a restricted species reactivity (as is the case with mIL-5r) or did not distinguish between IL-5 orthologs (similar to hIL-5r). gpIL-5 was cloned using mRNA isolated from cells obtained by bronchoalveolar lavage. Recombinant gpIL-5 was expressed in T. ni insect cells and purified from spent media. Binding assays were performed using insect cells expressing hIL-5ralphabeta or gpIL-5ralphabeta1 as previously described (Cytokine, 12:858-866, 2000) or using B13 cells which express mIL-5r. The agonist potency and efficacy properties of each IL-5 ortholog were evaluated by quantitating the proliferative response of human TF-1 cells and murine B13 cells. gpIL-5 bound with high affinity to recombinant gpIL-5r as demonstrated by displacing [125I]hIL-5 (Ki = 160 pM). gpIL-5 also bound to hIL-5r with high affinity (Ki = 750 pM). hIL-5 and mIL-5 showed similar, high-affinity binding profiles to both gpIL-5r and hIL-5r. In contrast, gpIL-5 and hIL-5 did not bind to the mIL-5r as demonstrated by an inability to displace [125I]mIL-5, even at 1000-fold molar excess. These differences in affinity for IL-5r orthologs correlated with bioassay results: human TF-1 cells showed roughly comparable proliferative responses to guinea pig, human and murine IL-5 whereas murine B13 cells showed a strong preference for murine over guinea pig and human IL-5 (EC50 = 1.9, 2200 and 720 pM, respectively). Recombinant gpIL-5 binds to the gpIL-5r with high affinity, similar to that seen with the human ligand-receptor pair. gpIL-5r and hIL-5r do not distinguish between the three IL-5 orthologs whereas mIL-5r has restricted specificity for its cognate ligand
Radiocarbon Date List X: Baffin Bay, Baffin Island, Iceland, Labrador Sea, and the Northern North Atlantic
Date List X contains an annotated listing of 213 radiocarbon dates determined on samples from marine and terrestrial environments. The marine samples were collected from the East Greenland, Iceland, Spitzbergen, and Norwegian margins, Baffin Bay, and Labrador Sea. The terrestrial samples were collected from Vestfirdir, Iceland and Baffin Island. The samples were submitted by INSTAAR and researchers affiliated with INSTAAR\u27s Micropaleontology Laboratory under the direction of Dr.’s John T. Andrews and Anne E. Jennings. All of the dates from marine sediment cores were determined from either shells or foraminifera (both benthic and planktic). All dates were obtained by the Accelerator Mass Spectrometry (AMS) method. Regions of concentrated marine research include: Baffin Bay, Baffin Island, Labrador Sea, East Greenland fjords, shelf and slope, Denmark Strait, the southwestern and northwestern Iceland shelves, and Vestfirdir, Iceland. The non-marine radiocarbon dates are from peat, wood, plant microfossils, and mollusc. The radiocarbon dates have been used to address a variety of research objectives such as: 1. determining the timing of northern hemisphere high latitude environmental changes including glacier advance and retreat, and 2. assessing the accuracy of a fluctuating reservoir correction. Thus, most of the dates constrain the timing, rate, and interaction of late Quaternary paleoenvironmental fluctuations in sea level, glacier extent, sediment input, and changes in ocean circulation patterns. Where significant, stratigraphic and sample contexts are presented for each core to document the basis for interpretations
Systematic Two-band Model Calculations of the GMR Effect with Metallic and Nonmetallic Spacers and with Impurities
By an accurate Green's function method we calculate conductances and the
corresponding Giant Magneto-Resistance effects (GMR) of two metallic
ferromagnetic films separated by different spacers, metallic and non-metallic
ones, in a simplified model on a sc lattice, in CPP and CIP geometries (i.e.
current perpendicular or parallel to the planes), without impurities, or with
interface- or bulk impurities. The electronic structure of the systems is
approximated by two hybridized orbitals per atom, to mimic s-bands and d-bands
and their hybridization.
We show that such calculations usually give rough estimates only, but of the
correct order of magnitude; in particular, the predictions on the impurity
effects depend strongly on the model parameters. One of our main results is the
prediction of huge CPP-GMR effects for {\it non-metallic} spacers in the
ballistic limit.Comment: Revised version; discussions and references improved; accepted by
JMM
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