Cross-sector collaborations are some of the strategies used to promote early childhood development and wellbeing. Without these collaborations, key services for families with young children may be missed or even duplicated. By drawing from experiences in Canada and Italy, we share findings from a study that aimed to understand the factors that make cross-sector collaborations (CSC) succeed or fail. Specifically, the study focused on understanding how CSC promoting early child development are created, maintained, and consolidated; and on identifying the social psychological, organizational, and economic aspects of CSC that help or hinder their functioning. Based on qualitative analysis of data gathered from four focus groups and thirteen interviews conducted across seven Canadian and Italian communities, we conclude that the success of CSC depend of a series of factors that transcend context, language and culture