720 research outputs found

    A space station onboard scheduling assistant

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    One of the goals for the Space Station is to achieve greater autonomy, and have less reliance on ground commanding than previous space missions. This means that the crew will have to take an active role in scheduling and rescheduling their activities onboard, perhaps working from preliminary schedules generated on the ground. Scheduling is a time intensive task, whether performed manually or automatically, so the best approach to solving onboard scheduling problems may involve crew members working with an interactive software scheduling package. A project is described which investigates a system that uses knowledge based techniques for the rescheduling of experiments within the Materials Technology Laboratory of the Space Station. Particular attention is paid to: (1) methods for rapid response rescheduling to accommodate unplanned changes in resource availability, (2) the nature of the interface to the crew, (3) the representation of the many types of data within the knowledge base, and (4) the possibility of applying rule-based and constraint-based reasoning methods to onboard activity scheduling

    P-31 magnetization transfer measurements of P-i -> ATP flux in exercising human muscle

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    Fundamental criticisms have been made over the use of (31)P magnetic resonance spectroscopy (MRS) magnetization transfer estimates of inorganic phosphate (P(i))→ATP flux (V(Pi-ATP)) in human resting skeletal muscle for assessing mitochondrial function. Although the discrepancy in the magnitude of V(Pi-ATP) is now acknowledged, little is known about its metabolic determinants. Here we use a novel protocol to measure V(Pi-ATP) in human exercising muscle for the first time. Steady-state V(Pi-ATP) was measured at rest and over a range of exercise intensities and compared with suprabasal oxidative ATP synthesis rates estimated from the initial rates of postexercise phosphocreatine resynthesis (V(ATP)). We define a surplus P(i)→ATP flux as the difference between V(Pi-ATP) and V(ATP). The coupled reactions catalyzed by the glycolytic enzymes GAPDH and phosphoglycerate kinase (PGK) have been shown to catalyze measurable exchange between ATP and P(i) in some systems and have been suggested to be responsible for this surplus flux. Surplus V(Pi-ATP) did not change between rest and exercise, even though the concentrations of P(i) and ADP, which are substrates for GAPDH and PGK, respectively, increased as expected. However, involvement of these enzymes is suggested by correlations between absolute and surplus P(i)→ATP flux, both at rest and during exercise, and the intensity of the phosphomonoester peak in the (31)P NMR spectrum. This peak includes contributions from sugar phosphates in the glycolytic pathway, and changes in its intensity may indicate changes in downstream glycolytic intermediates, including 3-phosphoglycerate, which has been shown to influence the exchange between ATP and P(i) catalyzed by GAPDH and PGK

    Long-term optical variability of PKS 2155-304

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    Aims: The optical variability of the blazar PKS 2155-304 is investigated to characterise the red noise behaviour at largely different time scales from 20 days to O(>10 yrs). Methods: The long-term optical light curve of PKS 2155-304 is assembled from archival data as well as from so-far unpublished observations mostly carried out with the ROTSE-III and the ASAS robotic telescopes. A forward folding technique is used to determine the best-fit parameters for a model of a power law with a break in the power spectral density function (PSD). The best-fit parameters are estimated using a maximum-likelihood method with simulated light curves in conjunction with the Lomb Scargle Periodogram (LSP) and the first-order Structure Function (SF). In addition, a new approach based upon the so-called Multiple Fragments Variance Function (MFVF) is introduced and compared to the other methods. Simulated light curves have been used to confirm the reliability of these methods as well as to estimate the uncertainties of the best-fit parameters. Results: The light curve is consistent with the assumed broken power-law PSD. All three methods agree within the estimated uncertainties with the MFVF providing the most accurate results. The red-noise behaviour of the PSD in frequency f follows a power law with f^-{\beta}, {\beta}=1.8 +0.1/-0.2 and a break towards f^0 at frequencies lower than f_min=(2.7 +2.2/-1.6 yrs)^-1.Comment: 10 pages, 8 figures, the ROTSE-light curve can be downloaded from http://vizier.cfa.harvard.edu/viz-bin/VizieR?-source=J/A+A/531/A12

    Is it Round? Spectropolarimetry of the Type II-P Supernova 1999em

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    We present the first multi-epoch spectropolarimetry of a type II plateau supernova (SN II-P), with optical observations of SN 1999em on days 7, 40, 49, 159, and 163 after discovery. These data are used to probe the geometry of the electron-scattering atmosphere before, during, and after the plateau phase, which ended roughly 90 days after discovery. Weak continuum polarization with an unchanging polarization angle (theta ~ 160 deg) is detected at all epochs, with p ~ 0.2% on day 7, p ~ 0.3% on days 40 and 49, and p ~ 0.5% in the final observations. Distinct polarization modulations across strong line features are present on days 40, 49, 159, and 163. Uncorrected for interstellar polarization (which is believed to be quite small), polarization peaks are associated with strong P Cygni absorption troughs and nearly complete depolarization is seen across the H-alpha emission profile. The temporal evolution of the continuum polarization and sharp changes across lines indicate polarization intrinsic to SN 1999em. When modeled in terms of the oblate, electron-scattering atmospheres of Hoeflich, the observed polarization implies anasphericity of at least 7% during the period studied. The temporal polarization increase may indicate greater asphericity deeper into the ejecta. We discuss the implications of asphericity on the use of type II-P supernovae as primary extragalactic distance indicators through the expanding photosphere method (EPM). If asphericity produces directionally dependant flux and peculiar galaxy motions are characterized by sigma_v_rec = 300 km/s, it is shown that the agreement between previous EPM measurements of SNe II and distances to the host galaxies predicted by a linear Hubble law restrict mean SN II asphericity to values less than 30% (3-sigma) during the photospheric phase.Comment: 65 pages (29 Figures, 4 Tables), Accepted for publication in the June 1, 2001 edition of ApJ. Revised statistical analysis of scatter in Hubble diagram of previous EPM distances and the implications for mean SN II asphericit

    Spectropolarimetry of the Luminous Narrow-Line Seyfert Galaxies IRAS 20181-2244 and IRAS 13224-3809

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    We observed the narrow-line Seyfert 1 galaxies IRAS 20181-2244 and IRAS 13324-3809 with a new spectropolarimeter on the RC spectrograph at the CTIO 4m telescope. Previously it had been suggested that IRAS 20181-2244 was a Type 2 QSO and thus might contain an obscured broad-line region which could be detected by the presence of broad Balmer lines in the polarized flux. We found the object to be polarized at about 2%, and constant with wavelength, (unlike most narrow-line Seyfert 1s), but with no evidence of broad Balmer lines in polarized flux. The spectropolarimetry indicates that the scattering material is inside the BLR. IRAS 13224-3809, notable for its high variability in X-ray and UV wavelengths, has a low polarization consistent with a Galactic interstellar origin.Comment: 19 pages using (AASTEX) aaspp4.sty and 5 postscript figures To be published in the Astrophysical Journa

    Codon usage influences fitness through RNA toxicity

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